Perelman School of Medicine Affiliations
Cell and Molecular Biology Graduate Program
Program in Cellular Physiology
B.A., Brandeis University, 1966
M.Phil., Yale University, 1969
Ph.D., Yale University, 1972
Research Career Development Award, 1981-1986
NSF Cell Physiology Advisory Panel 1985-88
Lindback Distinguished Teaching Award, University of Pennsylvania,
Society of General Physiologists Council 1996-98
Editorial Board, Journal of General Physiology, 2001-present
President, Society of General Physiologists, 2003-04
NIH Study Section (MDCN-3), 2003-07
Society of General Physiologists
The research of this laboratory has focused on the physiology
and biophysics of a voltage-gated potassium (Kv) channel
found in human T cells, Kv1.3. Thus far, we have shown that
Kv1.3 plays at least two functional roles. First, it contributes
to resting T-cell membrane potential, and second, it mediates
volume regulation. Both of these functions are critical in
mitogen-stimulated T-cell proliferation. Therefore, it is
important to understand what is responsible for the potassium
channel conductance in a T lymphocyte. There are two determinants:
the biophysical properties of the channel and the ability
of the channel to form and be expressed on the cell surface.
In the first case, we study the mechanisms of activation,
inactivation, and recovery of this channel. In the second
case, we study the stepwise process by which Kv1.3 acquires
its secondary, tertiary, and quaternary structure. These
studies involve a combined use of several diverse techniques
including electrophysiological techniques, in vitro translation
and transcription methods and protein assays, as well as
standard cloning and molecular biological methods.
J., Robinson, J.M., Edwards, D. and Deutsch, C.: T1-T1 Interactions
occur in the Endoplasmic Reticulum
while nascent Kv peptides are still attached to ribosomes.
Biochem. 40:10934-10946, 2001.
J. and Deutsch, C.: Pegylation: A method for assessing
topological accessibilities in Kv1.3.
A. and Deutsch, C.: Folding of the Voltage-gated K+ Channel
T1 Recognition Domain. J. Biol. Chem. 278: 4305-4313,
C.: Potassium Channel Ontogeny. Ann. Rev Physiol. 64:
C.: The Birth of a Channel. Neuron 40: 265-276, 2003.
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a full list of publications
(searches the National Library of Medicine's PubMed database.)