Mortimer Civan, MD

Emeritus Professor

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A303 Richards Building

3700 Hamilton Walk

Philadelphia, PA 19104

215-898-8773

Fax: 215-573-5851

civan@pennmedicine.upenn.edu

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Postdoctoral Research Fellow Juni Banerjee, PhD performing confocal microscopy.

Mortimer Civan, MD


Professor of Physiology

Other Perelman School of Medicine Affiliations


Degrees & Education

  • AB, Columbia College, 1955

  • MD, Columbia University, 1959


Honors

  • Fellow, American Association for the Advancement of Science

  • Established Investigator, American Heart Association

  • Member, American Society for Clinical Investigation

  • Overseas Fellow, Churchill College, University of Cambridge

  • Dean's Award for Excellence in Teaching Basic Science, University of Pennsylvania Perelman School of Medicine

  • Harold Chaffer Memorial Lecturer, Faculty of Medicine, University of Otago, Dunedin, New Zealand

  • Fellow, Assoc. for Research in Vision Ophthalmology


Professional Affiliations

  • Society of General Physiologists

  • American Society for Clinical Investigation

  • Association for Research in Vision & Ophthalmology

  • American Physiological Society

  • Biophysical Society

  • International Society for Eye Research

  • Salt and Water Club


Research Description

My laboratory is primarily concerned with: (1) the mechanisms of movement of solutes and water across epithelial membranes, (2) the regulation of that movement, and (3) the clinical implications of altering the underlying mechanisms and regulation. Our current focus is on the mechanisms and regulation of aqueous humor inflow into, and exit from, the eye, and their implications for the treatment of glaucoma. Two broad lines of in vitro work are in progress using the techniques of patch clamping, molecular biology, fluorescence microscopy and electronic cell sorting. First, we are seeking to identify the molecular basis for chloride-channel activity, which likely limits the rate of ciliary epithelial secretion. Second, we are also testing our current hypothesis concerning the autocrine and paracrine basis for purinergic regulation of aqueous humor secretion and efflux. We are testing our hypotheses, developed on the basis of our in vitro work, using measurements of intraocular pressure in the mouse.


Click here for a full list of publications.
(searches the National Library of Medicine's PubMed database.)


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