s Department of Physiology | Perelman School Of Medicine | University of Pennsylvania | Philadelphia, Pa

Carol Deutsch, PhD

Professor of Physiology

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650A Clinical Research Building

415 Curie Boulevard

Philadelphia, PA 19104

215-898-8014

Fax: 215-573-5851

cjd@mail.med.upenn.edu

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Carol Deutsch, PhD


Professor of Physiology

Other Perelman School of Medicine Affiliations


Degrees & Education

  • BA, Brandeis University, 1966

  • MPhil, Yale University, 1969

  • PhD, Yale University, 1972


Awards & Honors

  • 2003-2007 NIH Study Section (MDCN-3)

  • 2003-2004 President, Society of General Physiologists

  • 2001-2002Present Editorial Board, Journal of General Physiology

  • 1996-1998 Society of General Physiologists Counci

  • 1990 Lindback Distinguished Teaching Award, University of Pennsylvania

  • 1985-1988 NSF Cell Physiology Advisory Panel

  • 1981-1986 Research Career Development Award


Professional Affiliations

  • Society of General Physiologists

  • Biophysical Society


Research Description

The research of this laboratory has focused on the physiology and biophysics of a voltage-gated potassium (Kv) channel found in human T cells, Kv1.3. Thus far, we have shown that Kv1.3 plays at least two functional roles. First, it contributes to resting T-cell membrane potential, and second, it mediates volume regulation. Both of these functions are critical in mitogen-stimulated T-cell proliferation. Therefore, it is important to understand what is responsible for the potassium channel conductance in a T lymphocyte. There are two determinants: the biophysical properties of the channel and the ability of the channel to form and be expressed on the cell surface. In the first case, we study the mechanisms of activation, inactivation, and recovery of this channel. In the second case, we study the stepwise process by which Kv1.3 acquires its secondary, tertiary, and quaternary structure. These studies involve a combined use of several diverse techniques including electrophysiological techniques, in vitro translation and transcription methods and protein assays, as well as standard cloning and molecular biological methods.


Click here for a full list of publications.
(searches the National Library of Medicine's PubMed database.)


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