Ekaterina Grishchuk, PhD

Associate Professor

Lab Web Site

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675 Clinical Research Building

415 Curie Boulevard

Philadelphia, PA 19104

215-746-8178

Lab: 215-746-8177

Fax: 215-573-2273

gekate@mail.med.upenn.edu

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Ekaterina Grishchuk, PhD


Associate Professor of Physiology

Other Perelman School of Medicine Affiliations


Degrees & Education

  • MS, Moscow State University, 1990

  • PhD, University of Colorado at Boulder, 1997


Honors

  • 2014-18 Research Scholar, American Cancer Society

  • 2014 Michael S. Brown New Investigator Research Award, Univ. of Pennsylvania

  • 2012-14 Kimmel Scholar Award, The Sidney Kimmel Foundation for Cancer Research

  • 2010 Pennsylvania Muscle Institute Pilot Award

  • 2010 McCabe Foundation Pilot Award, Univ. of Pennsylvania

  • 2008 17th Annual MBoC Paper of the Year Award

  • 1993 Dean's Small Grant Award, Univ. of Colorado at Boulder

  • 1992 Dean's Small Grant Award, Univ. of Colorado at Boulder


Professional Affiliations

  • American Society for Cell Biology (ASCB)

  • Biophysical Society


Research Description

Our work aims to determine the mechanisms of accurate chromosome segregation during cell division. Specifically, we want to understand how spindle microtubules attach to kinetochore, a specialized chromosomal structure, and how these attachments drive chromosome motions that ultimately achieve faithful inheritance of genetic information. Errors in chromosome segregation constitute a serious threat to human health because they lead to abnormal genetic makeup, a hallmark feature of cancer cells, so knowledge of chromosome segregation mechanisms should ultimately assist developing novel and more specific anticancer drugs. In our experimental work we use highly advanced biophysical approaches, such as single-molecule fluorescence microscopy and laser tweezers, to study the interactions between isolated kinetochore proteins and dynamic microtubules in vitro under conditions that recapitulate aspects of normal chromosome-microtubule attachment in cells. Current research is focused on the kinesin motor CENP-E, microtubule-binding protein complexes Ndc80, Dam1 and Ska1, and the regulatory kinase Aurora B. With mathematical models we seek to develop a quantitative, mechanistic description of how these proteins interact with microtubules and function at the kinetochore interface, linking specific molecular characteristics with physiological behavior of normal and cancer mitotic cells.


Click here for a full list of publications.
(searches the National Library of Medicine's PubMed database.)


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