Anna Kashina, PhD

Professor of Biochemistry

Professor of Physiology

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Room 143 Rosenthal

3800 Spruce Street

Philadelphia, PA 19104

215-746-0895

akashina@vet.upenn.edu

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Anna Kashina, PhD


Professor of Biochemistry and Physiology (Secondary)

Other Perelman School of Medicine Affiliations


Degrees & Education

  • BS (Biochemistry) Moscow State University, 1986

  • MS (Biochemistry) Moscow State University, 1987

  • PhD (Cell Biology) Moscow Institute for Protein Research, 1993


Awards & Honors

  • Early Career Life Scientist Award, American Society for Cell Biology, 2010

  • Semi-finalist, Howard Hughes Medical Institute Early Career Scientist Competition, 2009

  • Pfizer Award for Research Excellence, 2007

  • American Cancer Society, Senior Postdoctoral Fellowship, 1996-1998


Professional Affiliations

  • Invited Editor, Proceedings of the National Academy of Sciences, USA, 2012

  • Member, University of Pennsylvania Cardiovascular Institute, 2009-present

  • Associate Member, University of Pennsylvania Abramson Cancer Center, 2008-present

  • Member, University of Pennsylvania Institute for Regenerative Medicine, 2008-present

  • Member, University of Pennsylvania Genomic Frontiers Institute, 2008-present

  • Ad hoc reviewer, National Science Foundation and US Civilian Research and Development Foundation, 2005-present

  • Member, Pennsylvania Muscle Institute, 2004-present

  • Member, Mari Lowe Cancer Center for Comparative Oncology, 2004-present

  • Peer reviewer for multiple scientific journals (including Nature, Journal of Cell Science, FEBS Letters, Breast Cancer Research and Treatment, Analytical Biochemistry, Chemistry and Biology, Trends in Biochemical Sciences, and others), 1996-present

  • Member, American Society for Cell Biology, 1994-present


Research Interests

  • Protein modifications, mouse genetics, cancer, cytoskeleton, cardiovascular development, angiogenesis.

Keywords

  • Protein arginylation, ATE1, arginyltransferase


Research Description

Genomes of higher mammals encode an estimated 40,000 proteins, however the complexity of the functions performed by these proteins in vivo is at least an order of magnitude higher. This complexity is achieved in a large part by posttranslational modifications that modulate structure and functions of proteins after synthesis, thus increasing the variety of forms in which the proteins encoded by the same gene can exist in vivo. Evidence suggests that posttranslational modifications constitute a major mechanism for regulation of normal metabolism and disease in higher vertebrates. Discovery and understanding of new posttranslational modifications and uncovering the biological role of the poorly understood modifications constitutes a major emerging field.

The goal of our research is to investigate the physiological role of a previously uncharacterized posttranslational modification, protein arginylation. Knockout of the enzyme responsible for arginylation, ATE1, results embryonic lethality in mice and multiple defects related to heart development and blood vessel remodeling (angiogenesis). Our recent work showed that arginylation regulates many proteins involved in cytoskeleton, cell motility, signaling, and metabolism, and uncovered some mechanisms of this regulation..

Our current studies are focused on three major directions: (1) identification of the ATE1 protein targets and studying the effect of arginylation on their properties and functions; (2) studies of the structure and molecular properties of the mouse ATE1 enzymes; and (3) discovering the mechanisms and pathways that lead to the global physiological effects of protein arginylation.


Lab Members

Reena Rai -- Research Specialist,

Sougata Saha -- Postdoctoral Scholar,

Junling Wang -- Postdoctoral Scholar,

Fangliang Zhang -- Postdoctoral Scholar,

Satoshi Kurosaka -- Postdoctoral Scholar,

Adrian Leu -- Research Specialist,

Li Huang -- Research Specialist

Click here for a full list of publications.
(searches the National Library of Medicine's PubMed database.)


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