J. Kevin Foskett, PhD

Isaac Ott Professor

Chair of Physiology

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From Our Chair


Welcome to the Department of Physiology in the Perelman School of Medicine at the University of Pennsylvania. Our Department is devoted to research, training, and education and strives to push the boundaries of scientific discovery and academic development. The Department’s internationally recognized faculty, in conjunction with post-doctoral fellows, graduate students, and staff, use innovative tools to uncover physical and chemical mechanisms of biological processes. Our frontiers span the molecular to organ level to determine how the human body functions in health and disease.

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Recent News


  • September 16, 2014

  • Toshinori Hoshi, Ph.D. involved in study that implicates neuronal HERG3/Kv11.3 potassium channels in the pathophysiology of bipolar spectrum disorder. Read more

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  • September 10, 2014

  • Professor Emeritus Robert Forster, MD was honored by the American Physiological Society with an interview for their Living History Project. Read more and see the interview!

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  • August 20, 2014

  • Congratulations to the PMI team of Ostap, Dominguez, Goldman, Holzbaur, and Shuman for receiving a renewal of their NIH P01!

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  • August 6, 2014

  • Katya Grishchuk, PhD makes the cover of MBoC with this image!
    See full image

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  • August 4, 2014

  • Erika Holzbaur, Ph.D. highlighted in Penn Medicine news release for her achievement in receiving the NIH Javits Neuroscience Investigator Award for Research on Neurodegeneration!
    Read the annoucement here!

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  • August 1, 2014

  • During his first rotation in the Holzbaur Lab, Andrew Moore won a Penn Medicine 2014 "Art in Science" award in the graduate student category, for his flourescent image titled Purple Flower: Mouse Neuromuscular Junction Stained with Snake Venom.
    Read and see more!

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  • July 24, 2014

  • Congratulations to the Dominguez lab who reported in this week’s issue of Science on the mechanism of actin filament pointed-end capping by tropomodulin.
    Read more

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  • July 18, 2014

  • Congratulations to Michael Greenberg, PhD (Ostap Lab) for receiving a prestigious Pathway to Independence Award (K99/R00) award from NIH/NHLBI.

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Events Calendar


  • Indira M. Raman, PhD

    Thursday, Sep. 18 - 4:00pm-5:00pm

    Richards B404

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  • POSTPONED: OTR Seminar: Kevin Foskett, PhD

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  • POSTPONED: OTR Reception

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  • Owen McManus, PhD

    Thursday, Oct. 2 - 4:00pm-5:00pm

    Richards B404

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Roberto Dominguez, PhD

Professor of Physiology

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Faculty Spotlight


The Dominguez lab focuses on understanding the molecular basis for how protein-protein interaction networks bring together signaling, cytoskeleton regulatory, and membrane scaffolding proteins to accomplish specialized functions such as cell motility, cell morphogenesis and intracellular transport. His lab uses a combination of structural biology (x-ray crystallography, SAXS, FRET) and biophysical (ITC, MALS, SAXS, FRET, TIRF) approaches and collaborative cellular studies.

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Ekaterina Grishchuk, PhD

Assistant Professor of Physiology

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Faculty Spotlight


The Grishchuk lab focuses on the mechanisms of chromosome motions. Dr. Katya Grishchuk’s initial training was in biophysics. She subsequently received a Ph.D. in biological sciences. During her post-doctoral training, she capitalized on her multidisciplinary background to establish long-term collaborations with biophysicists and computer scientists to build a state-of-the-art laser tweezers system, which allowed the first direct measurements of forces produced by the shortening of microtubules (Grishchuk et al., Nature, 2005).

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Toshinori Hoshi, PhD

Professor of Physiology

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Faculty Spotlight


The Hoshi lab is interested in the plasticity of cell excitability conferred by the modulation of ion channel activities. Dr. Toshinori Hoshi is an internationally-recognized leader in studies of ion channel regulation by various important stimuli, factors and reagents that were relatively unexplored, including oxidation of methionine, oxidation of cysteine, locally assembled proteins, free heme, and heme breakdown products such as carbon dioxide and bilirubin-oxidation end products. More recently, he has focused on the effects of polyunsaturated fatty acids, using a vertical approach that ranges from detailed studies of single ion channel gating transitions to how those molecular events affect blood pressure in freely moving mice.

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Contact Physiology


  • 700 Clinical Research Building

  • 415 Curie Boulevard

  • Philadelphia, PA 19104-6085


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