Perelman School of Medicine at the University of Pennsylvania

Professor of Physiology

Department of Physiology
A303 Richards Building
3700 Hamilton Walk
Philadelphia, PA 19104-6085

Phone: (215) 898-8773
Fax: (215) 573-5851

Other Perelman School of Medicine Affiliations
Cell and Molecular Biology Graduate Program
Program in Cellular Physiology
Bioengineering Graduate Group
Institute for Medicine and Engineering
Department of Medicine

A.B., Columbia College, 1955
M.D., Columbia University, 1959

Fellow, American Association for the Advancement of Science
Established Investigator, American Heart Association
Member, American Society for Clinical Investigation
Overseas Fellow, Churchill College, University of Cambridge
Faculty Scholar, Josiah Macy, Jr. Foundation
Dean's Award for Excellence in Teaching Basic Science, University of Pennsylvania School of Medicine
Harold Chaffer Memorial Lecturer, Faculty of Medicine, University of Otago, Dunedin, New Zealand
Fellow, Assoc. for Research in Vision $ Ophthalmology

Professional Affiliations
Society of General Physiologists
American Society for Clinical Investigation
Association for Research in Vision & Ophthalmology
American Physiological Society
Biophysical Society
International Society for Eye Research
Salt and Water Club

Research Description
My laboratory is primarily concerned with: (1) the mechanisms of movement of solutes and water across epithelial membranes, (2) the regulation of that movement, and (3) the clinical implications of altering the underlying mechanisms and regulation. Our current focus is on the mechanisms and regulation of aqueous humor inflow into, and exit from, the eye, and their implications for the treatment of glaucoma. Two broad lines of in vitro work are in progress using the techniques of patch clamping, molecular biology, fluorescence microscopy and electronic cell sorting. First, we are seeking to identify the molecular basis for chloride-channel activity, which likely limits the rate of ciliary epithelial secretion. Second, we are also testing our current hypothesis concerning the autocrine and paracrine basis for purinergic regulation of aqueous humor secretion and efflux. We are testing our hypotheses, developed on the basis of our in vitro work, using measurements of intraocular pressure in the mouse.


Click here for a full list of publications
(searches the National Library of Medicine's PubMed database.)

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