Other
Perelman School of Medicine Affiliations
Cell and Molecular Biology Graduate Program
Program in Cellular Physiology
Bioengineering Graduate Group
Institute for Medicine and Engineering
Department of Medicine
Degrees
A.B., Columbia College, 1955
M.D., Columbia University, 1959
Honors
Fellow, American Association for the Advancement of Science
Established Investigator, American Heart Association
Member, American Society for Clinical Investigation
Overseas Fellow, Churchill College, University of Cambridge
Faculty Scholar, Josiah Macy, Jr. Foundation
Dean's Award for Excellence in Teaching Basic Science, University
of Pennsylvania School of Medicine
Harold Chaffer Memorial Lecturer, Faculty of Medicine, University
of Otago, Dunedin, New Zealand
Fellow, Assoc. for Research in Vision $ Ophthalmology
Professional
Affiliations
Society of General Physiologists
American Society for Clinical Investigation
Association for Research in Vision & Ophthalmology
American Physiological Society
Biophysical Society
International Society for Eye Research
Salt and Water Club
Research
Description
My laboratory is primarily concerned with: (1) the mechanisms
of movement of solutes and water across epithelial membranes,
(2) the regulation of that movement, and (3) the clinical
implications of altering the underlying mechanisms and regulation.
Our current focus is on the mechanisms and regulation of
aqueous humor inflow into, and exit from, the eye, and their
implications for the treatment of glaucoma. Two broad lines
of in vitro work are in progress using the techniques of
patch clamping, molecular biology, fluorescence microscopy
and electronic cell sorting. First, we are seeking to identify
the molecular basis for chloride-channel activity, which
likely limits the rate of ciliary epithelial secretion. Second,
we are also testing our current hypothesis concerning the
autocrine and paracrine basis for purinergic regulation of
aqueous humor secretion and efflux. We are testing our hypotheses,
developed on the basis of our in vitro work, using measurements
of intraocular pressure in the mouse.
Selected
Publications
Mitchell,
C.H., Carré, D.A., McGlinn, A.M., Stone,
R.A. and Civan, M.M.: A novel release mechanism for stored
ATP in ocular ciliary epithelial cells. Proc. Natl. Acad.
Sci. (USA) 95: 7174-7178, 1998.
Avila, M.Y., Stone, R.A. and Civan, M.M.: Knockout of A3 Adenosine Receptors Reduces Mouse Intraocular Pressure. Invest. Ophthalmol. Vis. Sci. 43:3021-3026, 2002.
Do, C.-W., Peterson-Yantorno, K., Mitchell, C.H. and Civan, M.M.: cAMP-Activated Maxi-Cl- Channels in Native Bovine Pigmented Ciliary Epithelial Cells. Am. J. Physiol.: Cell Physiol. 287:C1003-11, 2004. Epub 2004 Jun 09 10.1152/ajpcell.00175.2004.
Karl, M.O., Fleischhauer, J.C., Stamer, W.D., Peterson-Yantorno, K., Mitchell, C.H., Stone, R.A. and Civan, M.M.: Differential P1-Purinergic Modulation of Human Schlemm´s Canal Inner-Wall Cells. Am. J. Physiol.: Cell Physiol. 288:C784-94, 2005. Epub 2004 Dec 8
Do, C.-W., Lu, W., Mitchell, C.H. and Civan, M.M.: Inhibition of Swelling-Activated Cl- Currents by Functional Anti-ClC-3 Antibody in Native Bovine Non-Pigmented Ciliary Epithelial Cells. Invest. Ophthalmol. Vis. Sci. 46:948-55, 2005.
Do, C.W., Peterson-Yantorno, K. and Civan, M.M.: Swelling-activated Cl- channels support Cl- secretion by bovine ciliary epithelium. Invest. Ophthalmol. Vis. Sci. 47: 2576–2582, 2006.
Wang, Z., Do, C.W., Avila, M.Y., Stone, R.A., Jacobson, K.A. and Civan, M.M.: Barrier qualities of the mouse eye to topically applied drugs. Exp. Eye Res. 85(1):105-12, 2007. Epub 2007 Mar 24.
McLaughlin, C.W., Zellhuber-McMillan, S., Macknight, A.D.C. and Civan, M.M.: Electron microprobe analysis of rabbit ciliary epithelium indicates enhanced secretion posteriorly and enhanced absorption anteriorly. Am.J. Physiol. Cell Physiol., Nov;293(5):C1455-66, 2007. Epub 2007 Aug 29.
McLaughlin, C.W., Karl, M.O., Zellhuber-McMillan, S., Wang, Z., Do, C.W., Leung, C.T., Li, A., Stone, R.A., Macknight, A.D.C. and Civan, M.M.: Electron Probe X-ray Microanalysis of Intact Pathway for Human Aqueous Humor Outflow. Am.J. Physiol. Cell Physiol. 295:C1083-C1091, 2008 Aug 27.
Calera, M.R., Wang, Z., Sanchez-Olea, R., Paul, D.L., Civan, M.M. and Goodenough, D.A.: Depression of intraocular pressure following inactivation of Connexin43 in the Non-Pigmented Epithelium of the ciliary body. Invest. Ophthalmol. Vis. Sci,, 50:2185-2193, 2009.
Wang, Z., Do, C.W., Avila, M.Y., Peterson-Yantorno, K., Stone, R.A., Gao, Z.-G., Joshi, B., Besada, P., Jeong, L.S., Jacobson, K.A. and Civan, M.M.: Nucleoside-derived antagonists to A3 adenosine receptors lower mouse intraocular pressure and act across species. Exp. Eye Res., 2009, doi:10.1016/j.exer.2009.10.001.
Civan, M.M.: Transporters beyond transport. Focus on “Deregulation of Apoptotic Volume Decrease and Ionic Movements in Multidrug Resistant Tumor Cells: Role of chloride channels”. Am. J. Physiol.: Cell Physiol., In press (#C-00459-2009).
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a full list of publications
(searches the National Library of Medicine's PubMed database.)
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