Other
School of Medicine Affiliations
Cell and Molecular Biology Graduate Program
Program in Cellular Physiology
Bioengineering Graduate Group
Institute for Medicine and Engineering
Degrees
A.B., Columbia College, 1955
M.D., Columbia University, 1959
Honors
Fellow, American Association for the Advancement of Science
Established Investigator, American Heart Association
Member, American Society for Clinical Investigation
Overseas Fellow, Churchill College, University of Cambridge
Faculty Scholar, Josiah Macy, Jr. Foundation
Dean's Award for Excellence in Teaching Basic Science, University
of Pennsylvania School of Medicine
Harold Chaffer Memorial Lecturer, Faculty of Medicine, University
of Otago, Dunedin, New Zealand
Professional
Affiliations
Society of General Physiologists
American Society for Clinical Investigation
American Society of Nephrology
Association for Research in Vision & Ophthalmology
American Physiological Society
Biophysical Society
International Society for Eye Research
Salt and Water Club
Research
Description
My laboratory is primarily concerned with: (1) the mechanisms
of movement of solutes and water across epithelial membranes,
(2) the regulation of that movement, and (3) the clinical
implications of altering the underlying mechanisms and regulation.
Our current focus is on the mechanisms and regulation of
aqueous humor inflow into, and exit from, the eye, and their
implications for the treatment of glaucoma. Two broad lines
of in vitro work are in progress using the techniques of
patch clamping, molecular biology, fluorescence microscopy
and electronic cell sorting. First, we are seeking to identify
the molecular basis for chloride-channel activity, which
likely limits the rate of ciliary epithelial secretion. Second,
we are also testing our current hypothesis concerning the
autocrine and paracrine basis for purinergic regulation of
aqueous humor secretion and efflux. We are testing our hypotheses,
developed on the basis of our in vitro work, using measurements
of intraocular pressure in the mouse.
Selected
Publications
Coca-Prados,
M., Sánchez-Torres, J.,
Peterson-Yantorno, K., and Civan, M.M.: Association of ClC-3
channel with Cl- transport by human nonpigmented ciliary
epithelial cells. J. Membrane Biol. 150:197-208, 1996.
Mitchell,
C.H., Carré, D.A., McGlinn, A.M., Stone,
R.A. and Civan, M.M.: A novel release mechanism for stored
ATP in ocular ciliary epithelial cells. Proc. Natl. Acad.
Sci. (USA) 95: 7174-7178, 1998.
McLaughlin,
C.W., Zellhuber-McMillan, S., Peart, D., Purves, R.D.,
Macknight, A.D.C. and Civan,
M.M.: Regional differences
in ciliary epithelial cell transport properties. J. Membrane
Biol. 182:213-222, 2001.
Avila,
M.Y., Stone, R.A. and Civan, M.M.: A1-, A2- and A3-Subtype
adenosine receptors
modulate intraocular pressure
in the
mouse. Br. J. Pharmacol. 134:241-245, 2001.
Fleischhauer,
J.C., Mitchell, C.H., Peterson-Yantorno, K., Coca-Prados,
M. and Civan, M.M.: PGE2, Ca2+ and
cAMP mediate
ATP activation of Cl- channels in pigmented ciliary
epithelial cells. Am. J. Physiol.: Cell Physiol.
281:C1614-1623, 2001.
Avila,
M.Y., Carré, D.A.,
Stone, R.A. and Civan, M.M.: Reliable Measurement of
Mouse Intraocular Pressure by a Servo-Null
Micropipette System. Invest. Ophthalmol. Vis. Sci.
42:1841-1846, 2001.
Mitchell,
C.H., Fleischhauer, J.C., Stamer, W.D., Peterson-Yantorno,
K.and Civan, M.M.: Human
trabecular
meshwork cell volume
regulation. Am. J. Physiol.: Cell Physiol. 283:
C315-C326, 2002.
Avila,
M.Y., Seidler, R.W., Stone, R.A. and Civan, M.M.: Inhibitors
of NHE-1 Na+/H+ exchange
reduce
mouse intraocular
pressure. Invest. Ophthalmol. Vis. Sci. 43:1897-1902,
2002.
Avila,
M.Y., Stone, R.A. and Civan, M.M.: Knockout of A3 Adenosine
Receptors Reduces Mouse Intraocular
Pressure.
Invest. Ophthalmol. Vis. Sci. 43:3021-3026,
2002.
Avila,
M.Y., Mitchell, C.H., Stone, R.A. and Civan, M.M.: Noninvasive
assessment of
aqueous
humor turnover
in the
mouse eye. Invest. Ophthalmol. Vis. Sci.
44:722-727, 2003.
Fleischhauer,
J.C., Mitchell, C.H., Stamer, W.D., Karl M.O., Peterson-Yantorno,
K.
and Civan, M.M.:
Common
actions of
adenosine receptor agonists in modulating
human trabecular meshwork cell transport.
J. Membrane
Biol., 193:121-136,
2003.
Click here for
a full list of publications
(searches the National Library of Medicine's PubMed database.)
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