Other
School of Medicine Affiliations
Associate Professor of Biochemistry and Biophysics
Degrees
B.A., Oxford University, 1963
M.A., Oxford University, 1966
D.Phil., Oxford University, 1966
Honors
E.A. Bennett Research Award in Basic Science (Society for
Biological Psychiatry), 1975
Mary and Christian F. Lindback Award for Distinguished Teaching,
1983
Professional
Affiliations
American Society for Biochemistry and Molecular Biology,
FASEB
Research
Interests
Integration and optimization algorithms, application of digital computers to
analysis of complex biological phenomena.
Research
Description
The connecting theme of Dr. Pring's research is the analysis
of complex biological phenomena by fitting mathematical representations
of physical models of the underlying processes to experimental
observations. The phenomena studied include biochemical reaction
networks, molecular and bulk transport processes, biophysical
transduction mechanisms, and various combinations of these.
One such area of recent study is the mechanisms and thermodynamics
of actin filament assembly and its control by proteins that
in varying combinations bind actin monomers and cutcap and
nucleate the filaments.
Representative
Publications
Lesh,
M.D., M. Pring, J.F. Spear. Cellular uncoupling can unmask
dispersion of action potential duration in ventricular
myocardium - a computer modeling study, Circ. Res., 65(5),
1426-1440, 1989.
Pring,
M., A. Weber, M. Bubb. Profilin-actin complexes directly
elongate actin filaments at the barbed
end. Biochemistry,
31, 1827-1836, 1992.
Pring,
M., L. Cassimeris, S.H. Zigmond, An unexplained sequestration
of latrunculin A is required
in neutrophils
for inhibition of actin polymerization. Cell Motility & the
Cytoskeleton. 52(2), 122-130, 2002.
Pring,
M., M. Evangelista, C. Boone, C. Yang, S.H. Zigmond,
Mechanism of formin-induced
nucleation of
actin filaments.
Biochemistry. 42(2), 486-496, 2003.
Zigmond,
S.H., M Evangelista, C. Boone, C. Yang, A.C. Dar, F.
Sicheri,
J. Forkey, M. Pring, Formin
leaky
cap allows
elongation in the presence of tight capping proteins.
Current Biology, 13, 1820-1823, 2003.
Click here for
a full list of publications
(searches the National Library of Medicine's PubMed database.)
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