Perelman School of Medicine at the University of Pennsylvania

Professor of Physiology

Institute for Medicine and Engineering
1010 Vagelos Laboratories
3340 Smith Walk
Philadelphia, PA 19104

Phone: (215) 573-7380
Fax: (215) 573-68151

Other Perelman School of Medicine Affiliations
Cell and Molecular Biology Graduate Group
Pennsylvania Muscle Institute

Ph.D., University of Wisconsin, 1982
A.B., Oberlin College, 1976

Rotschild-Yvette Mayent Award, Institut Curie, 1999

Professional Affiliations
American Society for Cell Biology
Biophysical Society

Research Description
Our lab studies several aspects of cell mechanics. In one project, we produce soft materials, usually hydrogels, to which cell adhesion proteins are linked to study how the stiffness of surfaces alters cell structure, function, and growth. Endothelial cells, fibroblasts, neurons and astrocytes each show unique dependence on substrate stiffness, and we seek to understand how they sense and respond to this mechanical cue. In related work we measure the structure and viscoelasticity of cytoskeletal polymer networks using a variety of imaging, scattering, and rheologic methods. Further studies examine how changes in cell membrane structure mediated by inositol phospholipids lead to production of signals that remodel the cytoskeleton.?


Click here for a full list of publications
(searches the National Library of Medicine's PubMed database.)

Back to list