Other Perelman School of Medicine Affiliations
Mahoney Institute of Neurological Sciences
Pennsylvania Muscle
Institute (PMI)
Degrees
MBBS, Delhi University, 1985
Ph.D., Harvard University, 1992
Honors
National Talent Search Scholarship, National Council
Education, Research & Training, India
Research Fellowship, Muscular Dystrophy Association,
USA
Clinical Investigator Development Award, National Institutes
of Health, USA
Professional
Affiliations
American Physiological Society
Association for Research in Vision and Ophthalmology
American Society for Human Genetics
World Muscle Society
Web Links
Khurana
Lab. at PMI
Research
Interests:
Duchenne's Muscular Dystrophy, NMJ-specific gene
regulation, Utrophin, Extraocular muscle, Myostatin,
Gene therapy.
Research
Description
We study
molecular mechanisms underlying muscle specializations
and patho-physiology of muscle
diseases. Topics include
developmental changes of muscle as a whole that
lead to the formation of
unique skeletal muscle group such as the extraocular
muscle (EOM), control of muscle size by growth
/ developmental factors, as well as formation
of synapses
or neuromuscular
junctions).
This research is also interesting from a disease
perspective since some of these molecules / pathways
(e.g. myostatin,
utrophin) offer therapeutic strategies for muscular
dystrophy.
Representative
Publications
Utrophin
Khurana
TS, Hoffman EP, and Kunkel LM. (1990) Identification of
a Chromosome 6 encoded Dystrophin-Related
Protein
J. Biol. Chem. 265, 16717-16720
Khurana
TS, Rosmarin AG, Shang, J., Krag TOB, Das S, and Gammeltoft
S (1999) Heregulin
activates
the utrophin
promoter
via the
transcription factor complex GABP alpha/beta.
Mol.
Biol. Cell. 10, 2075-2086
Gyrd-Hansen
M, Krag TOB, Rosmarin AG, and Khurana TS (2002) Sp1 and
the
ets-related
transcription
factor complex GABP
alpha/beta functionally cooperate to
activate the utrophin
promoter. J.
Neurol. Sci. 197, 27-35
Extraocular
Muscles
Khurana
TS, Prendergast RA, Alameddine H, Tome FMS, Fardeau M,
Arahata K,
Sugita H,
and Kunkel
LM. (1995)
Sparing
of extraocular muscles in Duchenne's
muscular dystrophy: Role
of calcium homeostasis.
J. Exp. Med. 182, 467-475
Niemann
CU, Krag TOB & Khurana TS (2000)
Identification of genes that are
differentially expressed in extraocular and
limb muscle. J. Neurol. Sci. 179,
76-84
Fischer
MD, Gorospe JR, Felder E, Bogdanovich S, Pedrosa-Domellof
F, Ahima RS, Rubinstein
NA, Hoffman
EP, Khurana TS
(2002) Expression profiling reveals
metabolic and structural components
of extraocular
muscles. Physiol. Genomics 9,
71-84.
Myostatin
Bogdanovich
S, Krag TO, Barton ER, Morris LD, Whittemore LA,
Ahima RS,
Khurana
TS (2002) Functional improvement
of dystrophic
muscle by myostatin blockade.
Nature 420, 418-420
Muscular Dystrophy
Khurana TS & Davies KE (2003) Pharmacological Strategies
for Muscular Dystrophy.[Review]. Nature Rev.
Drug Discov. 2, 379-390
Click here for
a full list of publications
(searches the National Library of Medicine's PubMed database.)
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