Penn Image-Guided Interventions Lab

Selected Publications

Basic and Translational Science

Perkons NR, Johnson O, Pilla G, Profka E, Mercadante M,  Ackerman D, Gade TP. “Functional genetic screening enables theranostic molecular imaging in cancer.” Clinical Cancer Research. In press. 2020. doi: 10.1158/1078-0432.CCR-20-0826

Beier UH, Hartung EA, Concors S, Hernandez PT, Wang Z, Perry C, Baur JA, Denburg MR, Hancock WW, Gade TP, Levine MH. Tissue metabolic profiling shows that saccharopine accumulates during renal ischemic-reperfusion injury, while kynurenine and itaconate accumulate in renal allograft rejection. Metabolomics. 2020 May 4;16(5):65. doi: 10.1007/s11306-020-01682-2: 32367163.

Wildenberg JC, Perkons NR, Pilla G, Kadlecek S, Gade TPF. Computational pipeline for estimation of small-molecule T1 relaxation times. J Magn Reson. 2020 May;314:106733. doi: 10.1016/j.jmr.2020.106733. PMID: 32339979; NIHMSID:NIHMS1587819.

Xi IL, Zhao Y, Wang R, Chang M, Purkayastha S, Chang K, Huang RY, Silva AC, Vallières M, Habibollahi P, Fan Y, Zou B, Gade TP, Zhang PJ, Soulen MC, Zhang Z, Bai HX, Stavropoulos SW. Deep Learning to Distinguish Benign from Malignant Renal Lesions Based on Routine MR Imaging. Clin Cancer Res. 2020 Apr 15;26(8):1944-1952. doi: 10.1158/1078-0432.CCR-19-0374. PMID: 31937619.

Zhao S, Jang C, Liu J, Uehara K, Gilbert M, Izzo L, Zeng X, Trefely S, Fernandez S, Carrer A, Miller KD, Schug ZT, Snyder NW, Gade TP, Titchenell PM, Rabinowitz JD, Wellen KE. Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate. Nature. 2020 Mar;579(7800):586-591. doi: 10.1038/s41586-020-2101-7. PMID: 32214246.

Park BJ, Hunt SJ, Martin C 3rd, Nadolski GJ, Wood BJ, Gade TP. Augmented and Mixed Reality: Technologies for Enhancing the Future of IR. J Vasc Interv Radiol. 2020 Feb 12;. doi: 10.1016/j.jvir.2019.09.020. Review. PubMed PMID: 32061520.

Stein EJ, Perkons NR, Wildenberg JC, Iyer SK, Hunt SJ, Nadolski GJ, Witschey WR, Gade TPF. MR Imaging Enables Real-Time Monitoring of In Vitro Electrolytic Ablation of Hepatocellular Carcinoma. J Vasc Interv Radiol. 2020 Feb;31(2):352-361. doi: 10.1016/j.jvir.2019.07.030. PMID: 31748127.

Lee P, Malik D, Perkons N, Huangyang P, Khare S, Rhoades S, Gong YY, Burrows M, Finan JM, Nissim I, Gade TPF, Weljie AM, Simon MC. Targeting glutamine metabolism slows soft tissue sarcoma growth. Nat Commun. 2020 Jan 24;11(1):498. doi: 10.1038/s41467-020-14374-1. PMID: 31980651; PubMed Central PMCID: PMC6981153.

Shi D, Kiefer RM, Nishiofuku H, Cortes A, Nadolski GJ, Hunt SJ, Avritscher R, Gade TPF. Angiographic Atlas of the Visceral Vascular Anatomy in Translational Rat Models. J Vasc Interv Radiol. 2019 Dec;30(12):2009-2015.e1. doi: 10.1016/j.jvir.2019.03.005. PMID: 31202678; PubMed Central PMCID: PMC7193740.

Perkons NR, Kiefer RM, Noji MC, Pourfathi M, Ackerman D, Siddiqui S, Tischfield D, Profka E, Johnson O, Pickup S, Mancuso A, Pantel A, Denburg MR, Nadolski GJ, Hunt SJ, Furth EE, Kadlecek S, Gade TPF. Hyperpolarized Metabolic Imaging Detects Latent Hepatocellular Carcinoma Domains Surviving Locoregional Therapy. Hepatology. 2019 Sep 25;. doi: 10.1002/hep.30970. PMID: 31553806; NIHMSID:NIHMS1587206.

Tischfield DJ, Ackerman D, Noji M, Chen JX, Johnson O, Perkons NR, Nadolski GJ, Hunt SJ, Soulen MC, Furth EE, Gade TP. Establishment of hepatocellular carcinoma patient-derived xenografts from image-guided percutaneous biopsies. Sci Rep. 2019 Jul 22;9(1):10546. doi: 10.1038/s41598-019-47104-9. PMID: 31332214; PMCID: PMC6646301.

Nishiofuku H, Cortes AC, Ensor JE, Minhaj AA, Polak U, Lopez MS, Kiefer R, Hunt SJ, Kichikawa K, Hicks ME, Gade TP, Avritscher R. Factors impacting technical success rate of image-guided intra-arterial therapy in rat orthotopic liver tumor model. Am J Transl Res. 2019;11(6):3761-3770. eCollection 2019. PMID: 31312386; PMCID: PMC6614632.

Nadolski GJ, Hunt SJ, Weber CN, Mohammed M, Pulido S, Noji M, Chisholm A, Gade TPF. Near-Infrared Fluorescence Imaging of Matrix Metalloproteinase 2 Activity as a Biomarker of Vascular Remodeling in Hemodialysis Access. J Vasc Interv Radiol. Sep 2018;29(9):1268-1275 e1261. PMID: 30061060.

Pantel AR, Ackerman D, Lee SC, Mankoff DA, Gade TP. Imaging Cancer Metabolism: Underlying Biology and Emerging Strategies. J Nucl Med. 2018 Sep;59(9):1340-1349. doi: 10.2967/jnumed.117.199869. Review. PMID: 30042161; PMCID: PMC6126440.

Perkons NR, Sheth R, Ackerman D, Chen J, Saleh K, Hunt SJ, Nadolski GJ, Shi J, Gade TP. The Implications of CRISPR-Cas9 Genome Editing for IR. J Vasc Interv Radiol. Sep 2018;29(9):1264-1267 e1261. PMID: 30146193.

Sheth RA, Perkons N, Dondossola E, Subudhi SK, Gade TP, Tam AL. Patient-Derived Xenograft Tumor Models: Overview and Relevance to IR. J Vasc Interv Radiol. 2018 Jun;29(6):880-882.e1. doi: 10.1016/j.jvir.2018.01.782. Review. PMID: 29798759.

Perkons NR, Stein EJ, Nwaezeapu C, Wildenberg JC, Saleh K, Itkin-Ofer R, Ackerman D, Soulen MC, Hunt SJ, Nadolski GJ, Gade TP. Electrolytic ablation enables cancer cell targeting through pH modulation. Commun Biol. May 2018;1:48. PMID: 30271931.

Kiefer RM, Hunt SJ, Pulido S, Pickup S, Furth EE, Soulen MC, Nadolski GJ, Gade TP. Relative Initial Weight is Associated with Improved Survival without Altering Tumor Latency in a Translational Rat Model of Diethylnitrosamine-Induced Hepatocellular Carcinoma and Transarterial Embolization. Journal of Vascular and Interventional Radiology. 2017 Jul;28(7):1043-1050. PMID: 28495453.

Gade TP, Tucker E, Nakazawa MS, Hunt SJ, Wong W, Krock B, Weber CN, Nadolski CN, Nadolski GJ, Clark TWI, Soulen MC, Furth EE, Winkler JD, Amaravadi RK, Simon MC. Ischemia Induces Quiescence and Autophagy in Hepatocellular Carcinoma. Radiology. 2017 Jun;283(3):702-710. PMID: 28253108. Featured in Science to Practice.

Hsu MC, Weber CN, Mohammed MA, Gade TP, Hunt S, Nadolski GJ, Clark TW. Thermal Changes during Rheolytic Mechanical Thrombectomy. Journal of Vascular and Interventional Radiology. 2016 Jun;27(6):905-12. PMID: 27103145.

Ge BH, Weber CN, Wildenberg JC, Nadolski GJ, Gade TP, Hunt SJ, Soulen MC, Itkin M. Magnetic Resonance-Monitored Coaxial Electrochemical Ablation--Preliminary Evaluation of Technical Feasibility. Journal of Vascular and Interventional Radiology. 2015 Aug;26(8):1238-46. PMID: 26210247.

Gade TP, Hunt SJ, Harrison N, Nadolski GJ, Weber C, Pickup S, Furth EE, Schnall MD, Soulen MC, Celeste Simon M. Segmental Transarterial Embolization in a Translational Rat Model of Hepatocellular Carcinoma. Journal of Vascular and Interventional Radiology. 2015 Aug;26(8):1229-37. PMID: 25863596.

Hunt SJ, Gade T, Soulen MC, Pickup S, Sehgal CM. Antivascular ultrasound therapy: magnetic resonance imaging validation and activation of the immune response in murine melanoma. Journal of Ultrasound in Medicine. 2015 Feb;34(2):275-87. PMID: 25614401.

Clinical Science

Alexander ES, Nadolski GJ, Soulen MC, Stavropoulos SW, Hunt SJ, Gade TP, Itkin M, Shamimi-Noori S. Iatrogenic celiac and hepatic artery dissections during intra-arterial regional tumor therapies: a 16-year retrospective review. Abdom Radiol (NY). 2019 Oct;44(10):3480-3485. doi: 10.1007/s00261-019-02203-z. PMID: 31471705.

Patel V, McLaughlin SW, Shlansky-Goldberg R, Gade T, Bonshock R, Hunt S, Stavropoulos SW, Trerotola SO, Soulen MC, Nadolski G. Complication rates of percutaneous biliary drainage in the presence of ascites. Abdom Radiol (NY). 2019 May;44(5):1901-1906. doi: 10.1007/s00261-019-01916-5. PMID: 30725128.

Habibollahi P, Shamchi SP, Choi JM, Gade TP, Stavropoulos SW, Hunt SJ, Dagli M, Sudheendra D, Mondschein JI, Soulen MC, Nadolski GJ. Association of Complete Radiologic and Pathologic Response following Locoregional Therapy before Liver Transplantation with Long-Term Outcomes of Hepatocellular Carcinoma: A Retrospective Study. J Vasc Interv Radiol. 2019 Mar;30(3):323-329. doi: 10.1016/j.jvir.2018.11.037. PubMed PMID: 30819472.

Seraj SM, Zadeh MZ, Werner TJ, Zhuang H, Gade T, Alavi A, Hunt SJ. Pretreatment volumetric parameters of FDG-PET predict the survival after Yttrium-90 radio-embolization in metastatic liver disease. Am J Nucl Med Mol Imaging. 2019;9(5):248-254. eCollection 2019. PMID: 31772823; PMCID: PMC6872476.

Tischfield DJ, Nadolski GJ, Hunt SJ, Itkin M, Shlansky-Goldberg RD, Gade TP. Retrospective comparison of outcomes and associated complications between large bore radiologically inserted gastrostomy tube types. Abdom Radiol (NY). Aug 2 2018. PMID: 30073401.

Habibollahi P, Hunt S, Bitterman T, Gade TP, Soulen MC, Nadolski G. Definitive locoregional therapy (LRT) versus bridging LRT and liver transplantation with wait-and-not-treat approach for very early stage hepatocellular carcinoma. Diagn Interv Radiol. Jul 2018;24(4):213-218. PMID: 30091712.

Kaplan DE, Mehta R, D'Addeo K, Gade TP, Taddei TH. Transarterial Chemoembolization within First 3 Months of Sorafenib Initiation Improves Overall Survival in Hepatocellular Carcinoma: A Retrospective, Multi-Institutional Study with Propensity Matching. J Vasc Interv Radiol. 2018 Apr;29(4):540-549.e4. doi: 10.1016/j.jvir.2017.11.033. PMID: 29477619; PubMed PMCID: PMC6104514.

Habibollahi P, Shamchi SP, Tondon R, Ecker BL, Gade TP, Hunt S, Soulen MC, Furth EE, Levine MH, Nadolski G. Combination of Neoadjuvant Transcatheter Arterial Chemoembolization and Orthotopic Liver Transplantation for the Treatment of Cirrhotomimetic Hepatocellular Carcinoma. J Vasc Interv Radiol. Feb 2018;29(2):237-243. PMID: 29221923.

Habibollahi P, Hunt S, Gade T, Dagli MS, Mondschein JI, Sudheendra D, Stavropoulos SW, Soulen M, Gregory N. The Impact of Bridging LRT on Survival in Patients Listed for Liver Transplantation. Cardiovasc Intervent Radiol. 2018 Jan;41(1):112-119. doi: 10.1007/s00270-017-1759-1. PubMed PMID: 28819771.

DePietro DM, Kiefer RM, Redmond JW, Workman AD, Nadolski GJ, Gade TP, Trerotola SO, Hunt SJ. Increasing Medical Student Exposure to IR through Integration of IR into the Gross Anatomy Course. J Vasc Interv Radiol. 2017 Oct;28(10):1455-1460. doi: 10.1016/j.jvir.2017.06.040. PubMed PMID: 28827012.

Duncan C, Nadolski GJ, Gade TP, Hunt SJ. Understanding the Lung Abscess Microbiome: Outcomes of Percutaneous Lung Parenchymal Abscess Drainage with Microbiologic Correlation. Cardiovascular and Interventional Radiology. 2017 Jun;40(6):1623-33. PMID: 28321543.

Chick JF, Chen JX, Bennett SJ, Chauhan NR, Reddy SN, Gade TP, Watts MM, Nadolski GJ. Incidental Regression of a Suspected Pancreatic Intraductal Papillary Mucinous Neoplasm after Nontarget Embolization. Journal of Vascular and Interventional Radiology. 2016 Jun;27(6):922-3. PMID: 27287972.

Duncan C, Hunt SJ, Gade T, Shlansky-Goldberg RD, Nadolski GJ. Outcomes of Percutaneous Cholecystostomy in the Presence of Ascites. Journal of Vascular and Interventional Radiology. 2016 Apr;27(4):562-6. PMID: 26898624.

Ge BH, Guzzo TJ, Nadolski GJ, Soulen MC, Clark TW, Malkowicz SB, Wein AJ, Hunt SJ, Stavropoulos SW. Percutaneous Renal Cryoablation: Short-Axis Ice-Ball Margin as a Predictor of Outcome. Journal of Vascular and Interventional Radiology. Mar;27(3):403-9. PMID: 26755344.