Penn Medicine

Education and Training

Chromosome Segregation and Cell Division

Major events in the cell cycle must be coordinated with each other to ensure the equal partitioning of genetic information from the parental cell to the two progeny cells. Among these events are chromosome segregation and cytokinesis, two fundamental processes that must be regulated both temporally and spatially. Microtubules and their associated motor proteins function together to exert the force that moves the chromosomes but how they do this is not well understood. In addition, the molecular mechanisms by which the spindle integrity is checked before cell division are far from clear. Cytokinesis is also carried out by a dynamic structure, the actomyosin contraction system. How the type II myosins and F-actin interact with each other to generate the contractile force is not known. Furthermore, the signal specifying the cell division site as well as the cell cycle signal triggering actin ring formation and contraction still remain to be identified and characterized. All these questions are being addressed in a variety of systems by several members of the PMI.

The following PMI Members at the University of Pennsylvania are investigating chromosome segregation and cell division:


Pennsylvania Muscle Institute
Perelman School of Medicine University of Pennsylvania
Director: E. Michael Ostap, Ph.D.

700A Clinical Research Building Philadelphia, PA 19104-6085 Phone: (215) 573-9758 Fax: (215) 898-2653