Penn Medicine

Education and Training

Cell Migration and Intracellular Transport

These are 3D maps of smooth-muscle myosin bound to F-actin in the presence and absence of ADP. The figures were obtained by cryo-electron microscopy coupled with helical image analysis and averaging. Comparisons of the 3D maps of actin-bound myosin reveal that there is a large structural change in the light-chain domain of myosin upon ADP binding. This data is the first to show directly that the regulatory domain acts as a rigid lever arm pivoting about the end of the motor domain.

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Pennsylvania Muscle Institute
Perelman School of Medicine University of Pennsylvania
Director: E. Michael Ostap, Ph.D.

700A Clinical Research Building Philadelphia, PA 19104-6085 Phone: (215) 573-9758 Fax: (215) 898-2653