Penn Medicine

Education and Training

Gene Therapy and Neuromuscular Disease

This figure shows the localization of alpha-actinin in a live cardiac myocyte. Chicken cardiac myocytes were obtained from 7-day-old embryos and were transfected with an expression vector encoding GFP-alpha-actinin. The dynamics of GFP-alpha-actinin was monitored by fluorescence microscopy, allowing for the visualization of myofibrillogenesis in the living muscle cell. The GFP-alpha-actinin incorporates into "Z-bodies" which apparently fuse to become the Z-bands of mature myofibrils.

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Pennsylvania Muscle Institute
Perelman School of Medicine University of Pennsylvania
Director: E. Michael Ostap, Ph.D.

700A Clinical Research Building Philadelphia, PA 19104-6085 Phone: (215) 573-9758 Fax: (215) 898-2653