Department of Anatomy, Philadelphia College of Osteopathic Medicine
Department of Anatomy
Philadelphia College of Osteopathic Medicine
4170 City Avenue
Philadelphia, PA 19131-1694
Phone: (215) 871-6852
Position: Assistant Professor
A primary research interest in the laboratory is the role of integrins associated with the myofibrillar cytoskeleton in mature and developing chick myofibers. In both C. elegans and Drosophila mutants lacking b integrin, aberrant skeletal muscle structure has been demonstrated. A key question is whether, in vertebrates, the absence of b1 or any other myofibrillar associated integrin can also result in aberrant muscle structure, possibly due to abnormal myofibrillar assembly or alternatively to loss of structural integrity of the myofibrillar cytoskeleton. The lab is currently investigating the temporal and spatial appearance of specific a & b integrins in skeletal and cardiac muscle In Vitro and In Vivo. A second major focus in the laboratory is the use of immunodendrimers to amplify the signal in western blotting protocols. The addition of an immunodendrimer to a standard western blot is intended to lower the threshold for protein detection.