Jon Martin Lindstrom

Department of Neuroscience, University of Pennsylvania School of Medicine

Contact Information

Department of Neuroscience
217 Stemmler Hall
Philadelphia, PA 19104
Phone: (215) 573-2859
Fax: (215) 573-2015
E-mail: jslkk@mail.med.upenn.edu
Position: Professor

Expertise

My laboratory studies the structure and function of nicotinic acelytcholine receptors from muscles and nerves as well as the autoimmune response to muscle nicotinic receptors which occurs in myasthenia gravis. These studies involve molecular biology, biochemistry, monoclonal antibodies, and electrophysiology.

Representative Publications

1. Wang, F., Gerzanich, V., Wells, G., Anand, R., Peng, X., Keyser, K., and Linstrom, J. 1996. Assembly of human neuronal nicotinic receptor a5 subunits with a3, b2, and b4 subunits. J. Biol. Chem. 271:17656-17665.
2. Gerzanich, V., Peng, X., Wang, F., Wells, G., Anand, R., Fletcher, S., and Lindstrom, J. 1995 Comparative pharmacology of epibatidine-a potent agonist for neuronal nicotinic acetylcholine receptors. Mol. Pharmacol. 48:774-782.
3. Linstrom, J. 1996. Neuronal nicotinic acetylcholine receptors, in Ion Channels, vol. IV. T. Narahashi, ed. Plenum, New York, pages 377-450.
4. Peng, X., Gerzanich, V., Anand, R., Whiting, P.J., and Lindstrom, J. 1994. Nicotine-induced increase in neural nicotinic receptors results from a decrease in the rate of receptor turnover. Mol. Pharmacol. 46:523-530.