Penn Medicine
   
 

Vivianne T. Nachmias, M.D.

Department of Cell and Developmental Biology

Contact Information

Department of Cell and Developmental Biology
141 ANAT-CHEM
Philadelphia, PA 19104-6058
Phone: (215) 898-3162
Fax: (215) 898-9871
E-mail: vnt@pobox.upenn.edu
Position: Assistant Professor

Expertise

The focus of the laboratory is the cytoskeleton. We are studying control of cytoskeleton protein levels. Recently we found that over-expression of thymosin causes increased total actin (G/F constant) and several other cytoskeletal proteins. Is this due to increased message levels or stabilization of the proteins? We are also studying the role of capping proteins (CapZ) in activated cells (regulated uncapping and muscle development).

Representative Publications

  1. Safer, D., Golla, R. and Nachmias, V.T. 1990. Isolation of a 5-Kda actin sequestering peptide from human blood platelets. Proc. Nat'l. Acad. USA 87:2536-2540.
  2. Nachmias, V.T., Philp, N.J., Momoyama, Y. and Choi, J. 1992. G-actin pool and messenger RNA during development of the apical processes of RPE in chick. Dev. Biol. 149:239-246.
  3. Nachmias, V.T., Cassimeris, L., Golla, R. and Safer, D. 1993. Thymosin beta four (Tb4) in activated platelets. Eur. J. Cell Biol. 61:314-320.
  4. Sanger, J.M., Golla, R., Safer, D., Choi, J.K., Yu, K.-R., Sanger, J.W. and Nachmias, V.T. 1995. Increasing intracellular concentrations of thymosin beta 4 in PtK2 cells: effects on stress fibers, cytokinesis and cell spreading. Cell Motil. Cytoskel. 31:307-322.
  5. Nachmias, V.T., Golla, R., Casella, J.F. and Barron-Casella, E. 1996. Cap Z, a calcium insensitive capping protein in resting and activated platelets. FEBS Letts. 378:258-262.
  6. Golla, R., Philp, N., Safer, D., Collins, L. and Nachmias, V.T. 1996. Over-expression of T-beta(4) in NIH 3T3 cells: increases cytoskeletal proteins and cell-substrate adhesion. Mol. Biol. Cell. 7:2192S.
  7. Safer, D. and Nachmias, V.T. Beta thymosins as actin binding peptides. Bioessays (invited review) 16:473-479, 1994.

 

 
Pennsylvania Muscle Institute
Perelman School of Medicine University of Pennsylvania
Director: E. Michael Ostap, Ph.D.

700A Clinical Research Building Philadelphia, PA 19104-6085 Phone: (215) 573-9758 Fax: (215) 898-2653