2011  |  Hide archive

Notch activation of jagged1 contributes to the assembly of the arterial wall.

Arginylation and methylation double up to regulate nuclear proteins and nuclear architecture in vivo.

Methods for imaging thick specimens: confocal microscopy, deconvolution, and structured illumination.

Measurement and simulation of myoplasmic calcium transients in mouse slow-twitch muscle fibres.

Guanylyl cyclase (GC)-A and GC-B activities in ventricles and cardiomyocytes from failed and non-failed human hearts: GC-A inactive in the failed cardiomyocyte.

Differential expression of PDE5 in failing and non-failing human myocardium.

Bimolecular integrin-ligand interactions quantified using peptide-functionalized dextran-coated microparticles.

Is functional hypertrophy and specific force coupled with the addition of myonuclei at the single muscle fiber level?

Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage.

Structural analysis of smooth muscle tropomyosin alpha and beta isoforms.

Nanoparticle shape improves delivery: Rational coarse grain molecular dynamics (rCG-MD) of taxol in worm-like PEG-PCL micelles.

Interconversion between intestinal stem cell populations in distinct niches.

A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues.

Polymer physics of the cytoskeleton.

Cathelicidin LL-37 increases lung epithelial cell stiffness, decreases transepithelial permeability, and prevents epithelial invasion by pseudomonas aeruginosa.

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November 2011

Ischemia induces P-selectin-mediated selective progenitor cell engraftment in the isolated-perfused heart.

In vivo rescue of alveolar macrophages from SP-A knockout mice with exogenous SP-A nearly restores a wild type intracellular proteome; actin involvement.

Divalent cation-dependent formation of electrostatic PIP(2) clusters in lipid monolayers.

Motor number controls cargo switching at actin-microtubule intersections in vitro.

Motor coordination via a tug-of-war mechanism drives bidirectional vesicle transport.

Myotilin dynamics in cardiac and skeletal muscle cells.

Measuring in vivo metabolite levels in brain.

Drug discovery for Duchenne muscular dystrophy via utrophin promoter activation screening.

The actin regulatory protein HS1 is required for antigen uptake and presentation by dendritic cells.

The evolution of the mitochondria-to-calcium release units relationship in vertebrate skeletal muscles.

Autoimmune regulator (AIRE) contributes to dectin-1-induced TNF-a production and complexes with capase recruitment domain-containing protein 9 (CARD9, spleen tyrosine kinase (Syk), and dectin-1.

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October 2011

Orexin turns up the heat on obesity.

Loss of IL-15 receptor a alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles.

Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis.

miRNA-processing enzyme Dicer is required in epicardium for coronary vasculature development.

The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis.

Natural killer cell lytic granule secretion occurs through a pervasive actin network at the immune synapse.

Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic.


Histone deacetylase 3 regulates smooth muscle differentation in neural crest cells and development of the cardiac outflow tract.

The potential for salmon fibrin and thrombin to mitigate pain subsequent to cervical nerve root injury.


Gelsolin and non-muscle myosin IIA interact to mediate calcium-regulated collagen phagocytosis.

Glucokinase activation repairs defective bioenergetics of islets of langerhans isolated from type-2-diabetics.


Paying the piper: The cost of Ca2+pumping during the mating call of toadfish.

Calcium indicators and calcium signalling in skeletal muscle fibres during excitation-contraction coupling.

Image defocus and altered retinal gene expression in chick: clues to the pathogenesis of ametropia.

Meiotic origins of maternal age-related aneuploidy.

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September 2011

Direct measurement of DNA-mediated colloidal interactions and their quantitative modeling.

The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation.

mmb1p binds mitochondria to dynamic microtubules.

Age-dependent susceptibility of chromosome cohesion to premature separase activation in mouse oocytes.

Resistance training improves vasoreactivity in end-stage heart failure patients on inotropic support.

Antibody to acetylcholine receptor in myasthenia gravis: Prevalence, clinical correlates, and diagnostic value.

Politicizing NIH funding: a bride to nowhere.

Micro-managing myocyte mitosis.

Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem W domain nucleation.

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August 2011

Fluoroscopic-assisted endobronchial intubation for single-lung ventilation in infants.

Trichostatin A abrogates airway constriction, but not inflammation in mouse and human asthma models.

Aurora B dynamics at centromeres create a diffusion-based phosphorylation gradient.

A novel missense mutation in the FGB g. 3354T> (p.Y41N), fibrinogen caracas VIII.

Restoration of anterior-posterior rotator cuff force balance improves shoulder function in a rat model of chronic massive tears.

Genetic therapy for the fetus: a once in a lifetime opportunity.

Posttranslational arginylation as a global biological regulator.

How deeply cells feel: methods for thin gels.

Genome-wide association identifies diverse causes of common variable immunodeficiency.

Evidence that a septin diffusion barrier is dispensable for cytokinesis in budding yeast.

Intra-articular changes precede extra-articular changes in the biceps tendon after rotator cuff tears in a rat model.

Structure, stability, and interaction of fibrin αC-Domain Polymers.

Diet-induced lethality due to loss of HDAC3 in heart and skeletal muscle.

Myosin Va and myosin VI coordinate their steps while engaged in an in vitro tug of war during cargo transport.

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July 2011

Upregulation of paxillin and focal adhesion signaling follows dystroglycan complex deletions and promotes a hypertensive state of differentiation.

Oss of IL-15 receptor α alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles.

Aortic aneurysm generation in mice with targeted deletion of integrin-linked kinase in vascular smooth muscle cells.

Improved survival after pulmonary metastasectomy for soft tissue sarcoma.

Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures.

Decreased cardiac functional reserve in heart failure with preserved systolic function.

Gene transfer to muscle from the isolated regional circulation.

A translatable, closed recirculation system for AAV6 vector-mediated myocardial gene delivery in the large animal.

Lever-arm mechanics of processive myosins.

Feedback control in sensing chromosome biorientation by the aurora B kinase.

Percutaneous transendocardial delivery of self-complementary adeno-associated virus 6 in the canine.

Chronic losartan administration reduces mortality and preserves cardiac but not skeletal muscle function in dystrophic mice.

Functional genomics applied to cardiovascular medicine.

Flow-dependent channel formation in clots by an erythrocyte-bound fibrinolytic agent.

Biceps tendon properties worsen initially but improve over time following rotator cuff tears in a rat model.

Measuring in vivo metabolite levels in brain.

Hepaticoduodenostomy vs hepaticojejunostomy for reconstruction after resection of choledochal cyst.

Lymphocyte signaling converges on microtubules.

Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes.

Bio-inspired, bioengineered and bimimetic drug delivery carriers.

Lung vascular targeting through inhalation delivery: Insight from filamentous viruses and other shapes.

Dysfunctional tendon collagen fibrillogenesis in collagen VI null mice.

Remodeling and repair of orthopedic tissue: Role of mechanical loading and biologics: Part II: Cartilage and bone.

Overexpression of SERCA1a in the mdx diaphragm reduces susceptibility to contraction-induced damage.

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June 2011

Myostatin is upregulated following stress in an erk-dependent manner and negatively regulates cardiomyocyte growth in culture and in a mouse model.

Mechanism of actin filament bundling by fascin.

Tissue-tissue interactions during morphogenesis of the outflow tract.

A hearing loss-associated myo1c (R156W) decreases the myosin duty ratio and force sensitivity.

Arp you ready for actin in the nucleus?

Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains.

Remodeling and repair of orthopedic tissue: Role of mechanical loading and biologics.

Cell shape and substrate rigidity both regulate cell stiffness.

Myostatin activation in patients with advanced heart failure and after mechanical unloading.

Differential regulation of PDE5 expression in left and right ventricles of feline hypertrophy models.

Current status of stem cell therapy in heart failure.

A novel missense mutation in the nuclear factor-κB essential modulator (NEMO) gene resulting in impaired activation of the NF-κB pathway and a unique clinical phenotype presenting as MRSA subdural empyema.

Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons.

Image defocus and altered retinal gene expression in chick: Clues to the pathogenesis of ametropia.

Structural evidence for perinuclear calcium microdomains in cardiac myocytes.

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies.

Striated acto-myosin fibers can reorganize and register in response to elastic interactions with the matrix.

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May 2011

Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lyosomes.

Effect of supraspinatus tendon repair technique on the infraspinatus tendon.

Mechanisms of mechanical signaling in development and disease.

α-Melanocyte-stimulating hormone and adrenocorticotropin concentrations in response to thyrotropin-releasing hormone and comparison with adrenocorticotropin concentration after domperidone administration in healthy horses and horses with pituitary pars intermedia dysfunction.

Dr. Hiroaki Takekura. A tribute to a life of science.

A novel conserved targeting motif found in ABCA transporters mediates trafficking to early post Golgi compartments.

Increased nicotinic acetylcholine receptor protein underlies chronic nicotine-induced up-regulation of nicotinic agonist binding sites in mouse brain.

Single-molecule fluorescence measurements of ribosomal translocation dynamics.

Gene profiling in experimental models of eye growth: clues to myopia pathogenesis.

Lack of collagen XVIII long isoforms affects kidney podocytes, whereas the short form is needed in the proximal tubular basement membrane.

Improved method of preparation of supported planar lipid bilayers as artificial membranes for antigen presentation.

Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene.

Cysteine shotgun-mass spectrometry (CS-MS) reveals dynamic sequence of protein structure changes within mutant and stressed cells.

Fast microfluidic temperature control for high resolution live cell imaging.

Impaired biomechanical properties of diabetic skin implications in pathogenesis of diabetic wound complications.

Arginyltransferase is an ATP-independent self-regulating enzyme that forms distinct functional complexes in vivo.

Hepatic stellate cells require a stiff environment for myofibroblastic differentiation.

Septin structure and function in yeast and beyond.

Comparison of Brownian-dynamics-based estimates of polymer tension with direct force measurements.

Sensing centromere tension: Aurora B and the regulation of kinetochore function.

Enhancement of single-molecule fluorescence signals by colloidal silver nanoparticles in studies of protein translation.

Changepoint analysis for single-molecule polarized total internal reflection fluorescence microscopy experiments.

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April 2011

Biophysical properties of normal and diseased renal glomeruli.

Curvature-coupled hydration of semicrystalline polymer amphiphiles yields flexible worm micelles but favors rigid vesicles: polycaprolactone-based block copolymers.

TonEBP stimulates multiple cellular pathways for adaptation to hypertonic stress: organic osmolyte-dependent and -independent pathways.

Morphologies of charged diblock copolymers simulated with a neutral coarse-grained model.

Regulation of collagen fibril nucleation and initial fibril assembly involves coordinate interactions with collagens V and XI in developing tendon.

Increased proteolysis, myosin depletion, and atrophic AKT-FOXO signaling in human diaphragm disuse.

Hypodysfibringogenaemia due to production of mutant fibrinogen alpha-chains lacking fibrinopeptide A and polymerisation knob 'A'.

Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency.

Genetic therapy for the fetus: a once in a lifetime opportunity.

Fluoroscopic-assisted endobronchial intubation for single-lung ventilation in infants.

Enhancing discovery and saving money with MERIT.

Dissociation of bimolecular αIIbβ3-fibrinogen complex under a constant tensile force.

Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons.

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March 2011

Measuring oxygen in living tissue: intravascular, interstitial, and "tissue" oxygen measurements.

Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways.

Laparoscopic hepaticoduodenostomy versus open hepaticoduodenostomy for reconstruction after resection of choledochal cyst ([Formula: see text]).

Single-molecule adhesion forces and attachment lifetimes of myosin-I phosphoinositide interactions.

The Caenorhabditis elegans mucin-like protein OSM-8 negatively regulates osmosensitive physiology via the transmembrane protein PTR-23.

The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation.

Therapeutic potential of plasma gelsolin administration in a rat model of sepsis.

Mechanical, compositional, and structural properties of the post-natal mouse achilles tendon.

Composition of coronary thrombus in acute myocardial infarction.

Hematopoietic lineage cell-specific protein 1 functions in concert with the Wiskott-Aldrich syndrome protein to promote podosome array organization and chemotaxis in dendritic cells.

Amniotic fluid levels of glial fibrillary acidic protein in fetal rats with retinoic acid induced myelomeningocele: a potential marker for spinal cord injury.

Evaluation of phototoxicity of dendritic porphyrin-based phosphorescent oxygen probes: an in vitro study.

The long term immunological response of swine after two exposures to a salmon thrombin and fibrinogen hemostatic bandage.

The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging.

Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: mass spectrometry mapping of most exons and cooperative domain designs based on single molecule mechanics.

Materials science: Bubble wrap of cell-like aggregates.

Chronic hypoxia impairs muscle function in the Drosophila model of Duchenne's muscular dystrophy (DMD).

Arg/Abl-binding protein, a Z-body and Z-band protein, binds sarcomeric, costameric, and signaling molecules.

Decreased loading after rotator cuff tears leads to improved biceps tendon properties in a rat model.

Neural and synaptic defects in slytherin, a zebrafish model for human congenital disorders of glycosylation.

Flow-dependent channel formation in clots by an erythrocyte-bound fibrinolytic agent.

Homeodomain only protein X is down-regulated in human heart failure.

IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.

Cumulative effects of hypercholesterolemia on tendon biomechanics in a mouse model.

Fetal surgery: progress and perspectives.

Effect of Kasai procedure on hepatic outcome in Alagille syndrome.

Targeting the activin type IIB receptor to improve muscle mass and function in the mdx mouse model of Duchenne Muscular Dystrophy.

Cell shape and substrate rigidity both regulate cell stiffness.

The autoimmune regulator (AIRE), which is defective in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy patients, is expressed in human epidermal and follicular keratinocytes and associates with the intermediate filament protein cytokeratin 17.

TRE17/ubiquitin-specific protease 6 (USP6) oncogene translocated in aneurysmal bone cyst blocks osteoblastic maturation via an autocrine mechanism involving bone morphogenetic protein dysregulation.

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February 2011

Protein unfolding accounts for the unusual mechanical behavior of fibrin networks.

mll ortholog containing functional domains of human MLL is expressed throughout the zebrafish lifespan and in haematopoietic tissues.

Sequential stages in the age-dependent gradual formation and accumulation of tubular aggregates in fast twitch muscle fibers: SERCA and calsequestrin involvement.

Actin structure and function.

Tropomyosin: The gatekeeper's view of the actin filament revealed.

A force-activated kinase in a catch smooth muscle.

Oxygen-Dependent Quenching of Phosphorescence Used to Characterize Improved Myocardial Oxygenation Resulting From Vasculogenic Cytokine Therapy.

IGF-I and vitamin C promote myogenic differentiation of mouse and human skeletal muscle cells at low temperatures.

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January 2011

Electron tomography of cryofixed, isometrically contracting insect flight muscle reveals novel actin-myosin interactions.

Biphasic targeting and cleavage furrow ingression directed by the tail of a myosin II.

Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition.

Biglycan recruits utrophin to the sarcolemma and counters dystrophic pathology in mdx mice.

Cathelicidin LL-37 peptide regulates endothelial cell stiffness and endothelial barrier permeability.

Kicking the epicardium up a notch.

Substance P inhibits natural killer cell cytotoxicity through the neurokinin-1 receptor.

Fascin1 Promotes Cell Migration of Mature Dendritic Cells.

Microsomal Prostaglandin E2 Synthase-1 Modulates the Response to Vascular Injury.

Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves.

Visualization and identification of the structures formed during early stages of fibrin polymerization.

The role of GH and IGF-I in mediating anabolic effects of testosterone on androgen-responsive muscle.

Resistance Training Improves Vasoreactivity in End-Stage Heart Failure Patients on Inotropic Support.

A Hearing-Loss Associated Myo1c Mutation (R156W) Decreases the Myosin Duty Ratio and Force Sensitivity.

Cardiac Myocyte Remodeling Mediated by N-cadherin-dependent Mechanosensing.

Endobronchial valves for emphysema.

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2012  |  Hide archive

Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI.

MRI/MRS evaluation of a female carrier of Duchenne muscular dystrophy.

T(2) mapping provides multiple approaches for the characterization of muscle involvement in neuromuscular diseases: a cross-sectional study of lower leg muscles in 5-15-year-old boys with Duchenne muscular dystrophy.

Characterizing local collagen fiber re-alignment and crimp behavior throughout mechanical testing in a mature mouse supraspinatus tendon model.

Tendon healing: repair and regeneration.

Hypercholesterolemia increases supraspinatus tendon stiffness and elastic modulus across multiple species.

Estimating the microtubule GTP cap size in vivo.

Signs of progress in gene therapy for muscular dystrophy also warrant caution.

Mechanical Transition from a-Helical Coiled Coils to -Sheets in Fibrin(ogen).

The a-Helix to -Sheet Transition in Stretched and Compressed Hydrated Fibrin Clots.

Secreted miRNAs suppress atherogenesis

Modulation of smooth muscle cell phenotype: the other side of the story.

Myocardin regulates BMP10 expression and is required for heart development.

SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models.

Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes.

SNARing platelet granule secretion.

Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development.

Sds22 and Repo-Man stabilize chromosome segregation by counteracting Aurora B on anaphase kinetochores.

Chromosome cohesion decreases in human eggs with advanced maternal age.

Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing.

An Evi1-C/EBP complex controls peroxisome proliferator-activated receptor ?2 gene expression to initiate white fat cell differentiation.

Resolving Two-dimensional Kinetics of the Integrin aIIb3-Fibrinogen Interactions Using Binding-Unbinding Correlation Spectroscopy.

Graphene-based environmental barriers.

Calcium regulation of myosin-I tension sensing.

Membrane-bound myo1c powers asymmetric motility of actin filaments.

Synergistic effects of SDF-1a chemokine and hyaluronic acid release from degradable hydrogels on directing bone marrow derived cell homing to the myocardium.

Characterization of in vivo dlg1 deletion on T cell development and function.

Exo70 stimulates the Arp2/3 complex for lamellipodia formation and directional cell migration.

Force-dependent detachment of kinesin-2 biases track switching at cytoskeletal filament intersections.

Nanoscale topography mediates the adhesion of F-actin.

Myosin IC generates power over a range of loads via a new tension-sensing mechanism.

Sites of glucose transporter-4 vesicle fusion with the plasma membrane correlate spatially with microtubules.

The Kinetochore-Bound Ska1 Complex Tracks Depolymerizing Microtubules and Binds to Curved Protofilaments.

Andrew Fielding Huxley (1917-2012).

Structural changes in isometrically contracting insect flight muscle trapped following a mechanical perturbation.

Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis.

Mutation of sec63 in zebrafish causes defects in myelinated axons and liver pathology.

Biomechanical profiling of Caenorhabditis elegans motility.

The cystic-fibrosis-associated {Delta}F508 mutation confers post-transcriptional destabilization on the C. elegans ABC transporter PGP-3.

Stress and aging induce distinct polyQ protein aggregation states.

Flightless I is a focal adhesion-associated actin-capping protein that regulates cell migration.

Smooth muscle tension induces invasive remodeling of the zebrafish intestine.

The Conformational State of Actin Filaments Regulates Branching by Actin-related Protein 2/3 (Arp2/3) Complex.

Nanoparticles at fluid interfaces: Exploiting capping ligands to control adsorption, stability and dynamics.

Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production

Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response.

Cardiomyocytes from late embryos and neonates do optimal work and striate best on substrates with tissue-level elasticity: metrics and mathematics.

Cell culture: Soft gels select tumorigenic cells.

Mechanical force in T cell receptor signal initiation.

Force-dependent detachment of kinesin-2 biases track switching at cytoskeletal filament intersections.

Triadin/Junctin double null mouse reveals a differential role for Triadin and Junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis.

Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development

Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype

Lymphatic endothelial progenitors bud from the cardinal vein and intersomitic vessels in mammalian embryos.

Is functional hypertrophy and specific force coupled with the addition of myonuclei at the single muscle fiber level?

SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and differentially defective in Hermansky-Pudlak syndrome models.

Expression profiling reveals novel hypoxic biomarkers in peripheral blood of adult mice exposed to chronic hypoxia.

Arginylation regulates myofibrils to maintain heart function and prevent dilated cardiomyopathy.

Opposing microtubule motors drive robust nuclear dynamics in developing muscle cells.

Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage.

Paying the piper: the cost of Ca2+ pumping during the mating call of toadfish.

Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production.

Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin II hypertension.

Bimolecular integrin-ligand interactions quantified using peptide-functionalized dextran-coated microparticles.

Stress and aging induce distinct polyQ protein aggregation states.

SnapShot: Axonal transport.

Long-term systemic myostatin inhibition via liver-targeted gene transfer in golden retriever muscular dystrophy.

Adaptor protein-3 in dendritic cells facilitates phagosomal toll-like receptor signaling and antigen presentation to CD4 (+) T cells.

Ultrastructure of cardiac muscle in reptiles and birds: optimizing and/or reducing the probability of transmission between calcium release units.

Spin-labeling magnetic resonance imaging detects increased myocardial blood flow after endothelial cell transplantation in the infarcted heart.

The cytoskeletal adaptor protein IQGAP1 regulates TCR-mediated signaling and filamentous actin dynamics.

Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast.

Meiotic origins of maternal age-related aneuploidy.

The cystic fibrosis-associated {Delta} F508 mutation confers post-transcriptional destabilization on the C. elegans ABC transporter PGP-3.

Ischemia induces P-selectin-mediated selective progenitor cell engraftment in the isolated-perfused heart.

Dynactin is required for transport initiation from the distal axon.

April 2012

Influence of decorin on the mechanical, compositional, and structural properties of the mouse patellar tendon.

Effect of preconditioning and stress relaxation on local collagen fiber re-alignment: inhomogeneous properties of rat supraspinatus tendon.

The upper band of the subscapularis tendon in the rat has altered mechanical and histologic properties.

Evaluation of affine fiber kinematics in human supraspinatus tendon using quantitative projection plot analysis.

Mechanisms of protein delivery to melanosomes in pigment cells.

Notch activation of Jagged1 contributes to the assembly of the arterial wall.

Age-dependent susceptibility of chromosome cohesion to premature separase activation in mouse oocytes.

Chromosomal instability: Mad2 beyond the spindle checkpoint.

Cutting edge: Asymmetric memory T cell division in response to rechallenge.

An evil-C/EBPβ complex controls Pparγ2 expression to initiate white fat cell differentiation.

Dynein tethers and stabilizes dynamic microtubule plus ends.

Muller cell expression of genes implicated in proliferative vitreoretinopathy is influenced by substrate elastic modulus.

Two new "protected" oxyphors for biological oximetry: properties and application in tumor imaging.

Intracellular calcium movements during excitation-contraction coupling in mammalian slow-twitch and fast-twitch muscle fibers.

Arginylation and methylation double up to regulate nuclear proteins and nuclear architecture in vivo.

Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans.

Epicardium-derived cardian mesenchymal stem cells: expanding the outer limit of heart repair.

Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI.

Kinetic schemes for post-synchronized single molecule dynamics.

Adeno-associated virus vector delivery to the heart.

Structural analysis of smooth muscle tropomyosin a and B isoforms.

Subcellular organization: Change of phase in partitioning the cellular milieu.

Methods for imaging thick specimens: confocal microscopy, deconvolution, and structured illumination.

March 2012

Dr. Hiroaki Takekura. A tribute to a life of science.

Real-time assay for testing components of protein synthesis.

Improved method of preparation of supported planar lipid bilayers as artificial membranes for antigen presentation.

In vivo nerve-macrophage interactions following peripheral nerve injury.

Scleroderma-like properties of skin from caveolin-1-deficient mice: implications for new treatment strategies in patients with fibrosis and systemic sclerosis.

Development and evaluation of multiple tendon injury models in the mouse.

Glenoid cartilage mechanical properties decrease after rotator cuff tears in a rat model.

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Mechanism of fibrin (ogen) forced unfolding.

On the mechanism of aC polymer formation in fibrin.

Islet1 derivatives in the heart are both neural crest and second heart field origin.

Synaptic vesicle distribution by conveyor belt.

Transcription factor regulation by mechanical stress.

Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells.

Coordinating tissue interactions: notch signaling in cardiac development and disease.

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout.

The loss of homeostatis in hemostasis: new approaches in treating and understanding acute disseminated intravascular coagulation in critically ill patients.

Divalent cation-dependent formation of electrostatic PIP2 cluster in lipid monolayers.

Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton.

Drug discovery for Duchenne muscular dystrophy via utrophin promoter activation screening.

Secreted miRNAs suppress atherogenesis.

Ligand mobility modulates immunological synapse formation and T cell activation.

G protein By-subunit signaling mediates airway hyperresponsiveness and inflammation in allergic asthma.

Mechanical, compositional, and structural properties of the post-natal mouse Achilles tendon.

Mechanical property changes during neonatal development and healing using a multiple regression model.

Divalent cation-dependent formation of electrostatic PIP2 clusters in lipid monolayers.

February 2012

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons.

Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics.

The evolution of the mitochondria-to-calcium release units relationship in vertebrate skeletal muscles.

Actin bends over backward for directional branching.

mmb1p binds mitochondria to dynamic microtubules.

Spin labeling-MRI detects increased myocardial blood flow post endothelial cell transplantation in the infarcted heart.

The potential for salmon fibrin and thrombin to mi tigate pain subsequent to cervical nerve root injury.

Cathelicidin LL-37 increases lung epithelial cell stiffness, decreases transepithelial permeability and prevents epithelial invasion by Pseudomonas aeruginosa.

Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure.

Genetic deletion of trkB. T1 increases neuromuscular function.

Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation.

Mutations in or near the tra nsmembrane domain alter PMEL amyloid formation from functional to pathogenic.

Motor proteins: Kinesin can replace Myosin.

Small molecule inhibitors of arginyltransferase regulate arginylation-dependent protein degradation, cell motility, and angiogenesis.

Determinants of synaptic strength vary across an axon arbor.

Factor IX expression in skeletal muscle of a severe hemophilia B patient 10 years after AAV-mediated gene transfer.

Evidence that a septin diffusion barrier is dispensable for cytokinesis in budding yeast.

Recapitulation of the Achilles tendon mechanical properties during neonatal development: A study of differential healing during two stages of development in a mouse model.

Interconversion between intestinal stem cell populations in distinct niches.

Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity.

Gelation of semiflexible polyelectrolytes by multivalent counterions.

Divalent cation-induced cluster formation by polyphosphoinositides in model membranes.

Rescue of dystrophic skeletal muscle by PGC-1a involves a fast to slow fiber type shift in the mdx mouse.

Fiber-aligned polymer scaffolds for rotator cuff repair in a rat model.

Monitoring cardiopulmonary function and progression toward shock: Oxygen micro-sensor for peripheral tissue.

MicroRNA-processing enzyme Dicer is required in epicardium for coronary vasculature development.

Salmon fibrin glue in rats: Antibody studies.

Alterations of overused supraspinatus tendon: a possible role of glycosaminoglycans and HARP/pleiotrophin in early tendon pathology.

Regional variation in human supraspinatus tendon proteoglycans: Decorin, biglycan, and aggrecan.

Myostatin is elevated in congenital heart disease and after mechanical unloading.

Asymmetric B cell division in the germinal center reaction.

Trichostatin a abrogates airway constriction, but not inflammation, in murine and human asthma models.

The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease.

The azimuthal path of myosin V and its dependence on lever-arm length.

Signs of progress in gene therapy for muscular dystrophy also warrant caution.

January 2012

Translational regulation of utrophin by miRNAs.

Reprogramming cardiomyocyte mechanosensing by crosstalk between integrins and hyaluronic acid receptors.

The TRE17/USP6 oncogene: a riddle wrapped in a mystery inside an enigma.

Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease.

Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish.

Microtubules, axonal transport, and neuropathy.

Direct measurements of DNA-mediated colloidal interactions and their quantitative modeling.

Adaptations to pulsatile versus nonpulsatile ventricular assist device support.

Decreased loading after rotator cuff tears leads to improved biceps tendon properties in a rat model.

Collagen fiber re-alignment in a neonatal developmental mouse supraspinatus tendon model.

2013  |  Hide archive

Loss of ATE1-mediated arginylation leads to impaired platelet myosin phosphorylation, clot retraction, and in vivo thrombosis formation.

Late-onset anti-NMDA receptor encephalitis.

Kindlin ignites a new flame.

Imaging individual spindle microtubule dynamics in fission yeast.

Actin network disassembly powers Listeria monocytogenes dissemination.

Micro-mold Design Controls the 3D Morphological Evolution of Self-assembling Multi-cellular Microtissues.

A Knockin Mouse Model of Human PHD2-Associated Erythrocytosis Establishes a Haploinsufficiency Mechanism.

The nuclear receptor Rev-erba controls circadian thermogenic plasticity.

Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips.

CARMIL leading edge localization depends on a non-canonical PH domain and dimerization.

Long-Distance Axonal Transport of AAV9 is Driven by Dynein and Kinesin-2 and is Trafficked in a Highly Motile Rab7-Positive Compartment.

Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production.

Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response.

Remembrance of Hugh E. Huxley, a founder of our field.

Studying mitochondria and microtubule localization and dynamics in standardized cell shapes.

Long-term wheel running compromises diaphragm function but improves cardiac and plantarflexor function in the mdx mouse.

Glia Maturation Factor (GMF) Interacts with Arp2/3 Complex in a Nucleotide State-dependent Manner.

From tissue mechanics to transcription factors.

Dynein Interacts with the Neural Cell Adhesion Molecule (NCAM180) to Tether Dynamic Microtubules and Maintain Synaptic Density in Cortical Neurons.

Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation.

Daughter cell identity emerges from the interplay of cdc42, septins, and exocytosis.

Specific in vivo labeling of tyrosinated α-tubulin and measurement of microtubule dynamics using a GFP tagged, cytoplasmically expressed recombinant antibody.

Evaluation of the effects of age and pituitary pars intermedia dysfunction on corneal sensitivity in horses.

Responsive Multi-Domain Free-Standing Films of Gold Nanoparticles Assembled by DNA-Directed Layer-by-Layer Approach.

RhoA Is Essential for Maintaining Normal Megakaryocyte Ploidy and Platelet Generation.

GMF Interacts With Arp2/3 Complex In a Nucleotide State-Dependent Manner.

Ordered Recruitment of Dynactin to the Microtubule Plus-End is Required for Efficient Initiation of Retrograde Axonal Transport.

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors.

Dynactin Subunit p150(Glued) Is a Neuron-Specific Anti-Catastrophe Factor.


Ventilatory Chemosensory Drive Is Blunted in the mdx Mouse Model of Duchenne Muscular Dystrophy (DMD).


CLHM-1 is a Functionally Conserved and Conditionally Toxic Ca2+-Permeable Ion Channel in Caenorhabditis elegans.


Increased CDK1 activity determines the timing of kinetochore-microtubule attachments in meiosis I.


Method for measuring single-molecule adhesion forces and attachment lifetimes of protein-membrane interactions.

Regulation and control of myosin-I by the motor and light chain-binding domains.

Counting chromosomes in intact eggs.

Duchenne muscular dystrophy drug discovery - the application of utrophin promoter activation screening.

COL6A3 Protein Deficiency in Mice Leads to Muscle and Tendon Defects Similar to Human Collagen VI Congenital Muscular Dystrophy.

Erythrocytosis and Pulmonary Hypertension in a Mouse Model of Human HIF2A Gain of Function Mutation.

Quantum and All-Atom Molecular Dynamics Simulations of Protonation and Divalent Ion Binding to Phosphatidylinositol 4,5-Bisphosphate (PIP2).

Long tethers provide high-force coupling of the Dam1 ring to shortening microtubules.

A slippery walk to the microtubule-end.

Lgr5 Identifies Progenitor Cells Capable of Taste Bud Regeneration after Injury.

Dynamics of translation by single ribosomes through mRNA secondary structures.

Tb3+-tRNA for LRET Studies of Protein Synthesis.

Local Cytoskeletal and Organelle Interactions Impact Molecular-Motor- Driven Early Endosomal Trafficking.

Rickettsia Sca2 has evolved formin-like activity through a different molecular mechanism.

Ezrin/Radixin/Moesin proteins and flotillins cooperate to promote uropod formation in T cells.

Controversy and consensus regarding myosin II function at the immunological synapse.

Targeting and functional mechanisms of the cytokinesis-related F-BAR protein Hof1 during the cell cycle.

Comparison of myoplasmic calcium movements during excitation-contraction coupling in frog twitch and mouse fast-twitch muscle fibers.

Mechanobiology of bone marrow stem cells: From myosin-II forces to compliance of matrix and nucleus in cell forms and fates.

The pro-forms of insulin-like growth factor I (IGF-I) are predominant in skeletal muscle and alter IGF-I receptor activation.

New Modulators for IGF-I Activity within IGF-I Processing Products.

Matrix-metalloproteinase 13 (MMP-13) is a new contributor to skeletal muscle regeneration and critical for myoblast migration.

Orchestration of secretory protein folding by ER chaperones.

Counting chromosomes in intact eggs.

Management of ventricular arrhythmias in patients with ventricular assist devices.

Divergent Mitochondrial Biogenesis Responses in Human Cardiomyopathy.

Extra-Hepatic Cholangiocyte Cilia are Abnormal in Biliary Atresia.

Duchenne muscular dystrophy drug discovery - the application of utrophin promoter activation screening.

Col6a3 Deficiency in Mice Leads to Muscle and Tendon Defects Similar to Human Collagen VI Congenital Muscular Dystrophy.

Erythrocytosis and Pulmonary Hypertension in a Mouse Model of Human HIF2A Gain-of-Function Mutation.

The PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB.

Ultrastructure of protrusive actin filament arrays.

Conserved and divergent features of kinetochores and spindle microtubule ends from five species.

Long tethers provide high-force coupling of the Dam1 ring to shortening microtubules.

Tilting and wobble of myosin V by high-speed single-molecule polarized fluorescence microscopy.

Dynamics of translation by single ribosomes through mRNA secondary structures.

Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions.

Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles.

Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes.

Ezrin and moesin are required for efficient T cell adhesion and homing to lymphoid organs.

Controversy and consensus regarding myosin II function at the immunological synapse.

Ezrin/Radixin/Moesin proteins and flotillins cooperate to promote uropod formation in T cells.

Immobile myosin-II plays a scaffolding role during cytokinesis in budding yeast.

Targeting and functional mechanisms of the cytokinesis-related F-BAR protein Hof1 during the cell cycle.

Specific In Vivo Labeling of Tyrosinated a-Tubulin and Measurement of Microtubule Dynamics Using a GFP Tagged, Cytoplasmically Expressed Recombinant Antibody.

Comparison of myoplasmic calcium movements during excitation-contraction coupling in frog twitch and mouse fast-twitch muscle fibers.

Orchestration of secretory protein folding by ER chaperones.

Regulation and control of myosin-I by the motor and light chain-binding domains.

Myosin VI has a One Track Mind Versus Myosin Va When Moving on Actin Bundles or at an Intersection.

Overexpression of IGF-1 attenuates skeletal muscle damage and accelerates muscle regeneration and functional recovery after disuse.

Pharmacology of myopia and potential role for intrinsic retinal circadian rhythms.

Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury.

Sounds of silence: synonymous nucleotides as a key to biological regulation and complexity.

Orienting actin filaments for directional motility of processive Myosin motors.

Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury.

Immobile myosin-II plays a scaffolding role during cytokinesis in budding yeast.

Caenorhabditis elegans HSF-1 is an essential nuclear protein that forms stress granule-like structures following heat shock.

Synergistic activation of p21-activated kinase 1 by phosphatidylinositol 4,5-bisphosphate and Rho GTPases.

MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16.

Pmel: A Pigment Cell-Specific Model For Functional Amyloid Formation.

Dynamic Domains in Polymersomes: Mixtures of Polyanionic and Neutral Diblocks Respond More Rapidly to Changes in Calcium than to pH.

Platelets lacking PIP5KI? have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion.

Mechanisms of fibrin polymerization and clinical implications.

Structure-function relationships of postnatal tendon development: A parallel to healing.

Smooth muscle cell plasticity: fact or fiction?

 

2013  2012  2011

Collaborative Multi-PI Publications from PMI Members HERE

RECENT PUBLICATIONS

Redox controls UPR to control redox.

Effects of Aging on Osteogenic Response and Heterotopic Ossification Following Burn Injury in Mice.

Memories of annemarie weber.

Labeled EF-Tus for rapid kinetic studies of pre-translocation complex formation.

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin.

Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress.

Examination of effects of corticosteroids on skeletal muscles of boys with DMD using MRI and MRS.

Scapular dyskinesis is detrimental to shoulder tendon properties and joint mechanics in a rat model.

Effect of isolated hyperglycemia on native mechanical and biologic shoulder joint properties in a rat model.

Epigenetic memory and cardiac cell therapy.

Monitoring coagulopathies in fluid resuscitation for trauma or surgery.

Ataluren treatment of patients with nonsense mutation dystrophinopathy.

Csi1p recruits alp7p/TACC to the spindle pole bodies for bipolar spindle formation.

Actin cytoskeleton. Mechanism of actin filament pointed-end capping by tropomodulin.

Navigating the cell: how motors function in vivo.

Absence of y-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle.

Autophagosome biogenesis in primary neurons follows an ordered and spatially regulated pathway.

GLP-1 Agonist Therapy for Advanced Heart Failure With Reduced Ejection Fraction: Design and Rationale for the Functional Impact of GLP-1 for Heart Failure Treatment Study.

Vimentin Enhances Cell Elastic Behavior and Protects against Compressive Stress.

Intra-articular tibiofemoral injection of a nonsteroidal anti-inflammatory drug has no detrimental effects on joint mechanics in a rat model.

Accurate phosphoregulation of kinetochore-microtubule affinity requires unconstrained molecular interactions.

Integrated regulation of motor-driven organelle transport by scaffolding proteins.

The role of animal models in tendon research.

Isolation of neonatal extrahepatic cholangiocytes.

The nuclear lamina is mechano-responsive to ECM elasticity in mature tissue.

From stealthy polymersomes and filomicelles to "self" Peptide-nanoparticles for cancer therapy.

LC3 Binding to the Scaffolding Protein JIP1 Regulates Processive Dynein-Driven Transport of Autophagosomes.

Kinetochore-microtubule attachment throughout mitosis potentiated by the elongated stalk of the kinetochore kinesin CENP-E.

Feedback control of chromosome separation by a midzone Aurora B gradient.

Fission yeast mtr1p regulates interphase microtubule cortical dwell-time.

Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle.

Structural basis for the nonlinear mechanics of fibrin networks under compression.

Fluid shear stress threshold regulates angiogenic sprouting

Long-term administration of the TNF blocking drug Remicade (cV1q) to mdx mice reduces skeletal and cardiac muscle fibrosis, but negatively impacts cardiac function.

Stress Sensitivity and Mechanotransduction during Heart Development.

Combining insoluble and soluble factors to steer stem cell fate.

The Portal Fibroblast-Not Just a Poor Man's Stellate Cell.

Sema3d and Sema3e Direct Endothelial Motility through Distinct Molecular Signaling Pathways.

Material control of stem cell differentiation: challenges in nano-characterization.

Diabetes Alters Mechanical Properties and Collagen Fiber Re-Alignment in Multiple Mouse Tendons.

Highly extensible skeletal muscle in snakes.

PDE5 inhibition alleviates functional muscle ischemia in boys with Duchenne muscular dystrophy.

Matrix Biology of Idiopathic Pulmonary Fibrosis: A Workshop Report of the National Heart, Lung, and Blood Institute.

Intracellular calcium movements during relaxation and recovery of superfast muscle fibers of the toadfish swimbladder.

Mature IGF-I excels in promoting functional muscle recovery from disuse atrophy compared with pro-IGF-IA.

Diaphragm remodeling and compensatory respiratory mechanics in a canine model of Duchenne muscular dystrophy.

A Mouse Model for Dominant Collagen VI Disorders: HETEROZYGOUS DELETION OF Col6a3 EXON 16.

Gene transfer of arginine kinase to skeletal muscle using adeno-associated virus.

Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors.

From ab initio calculations to multiscale design of si/c core-shell particles for li-ion anodes

AAV Serotypes 1, 8, and 9 Share Conserved Mechanisms for Anterograde and Retrograde Axonal Transport.

Echocardiography parameters of clinically normal adult captive chimpanzees (Pan troglodytes).

Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.

Cytokinesis defines a spatial landmark for hepatocyte polarization and apical lumen formation.

Gene transfer of arginine kinase to skeletal muscle using adeno-associated virus.

Inhibition of TGF Signaling Increases Direct Conversion of Fibroblasts to Induced Cardiomyocytes.

Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors.

Sept6 is required for ciliogenesis in Kupffer's vesicle, pronephros and neural tube during early embryonic development.

Tailoring the Physical Properties of Molybdenum Disulfide Monolayers by Control of Interfacial Chemistry.

Visualizing single rod-shaped fission yeast vertically in micro-sized holes on agarose pad made by soft lithography.

Enhanced lysis and accelerated establishment of viscoelastic properties of fibrin clots are associated with pulmonary embolism.

Subunit Rtt102 Controls the Conformation of the Arp7/9 Heterodimer and Its Interactions with Nucleotide and the Catalytic Subunit of SWI/SNF Remodelers.

Label-free mass spectrometry exploits dozens of detected peptides to quantify lamins in wildtype and knockdown cells.

The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation.

Highly Transient Molecular Interactions Underlie the Stability of Kinetochore-Microtubule Attachment During Cell Division.

Counterion-mediated cluster formation by polyphosphoinositides.

Disruption of the anterior-posterior rotator cuff force balance alters joint function and leads to joint damage in a rat model.

Diaphragm Remodeling and Compensatory Respiratory Mechanics in a Canine Model of Duchenne Muscular Dystrophy.

Recycling Endosome Tubule Morphogenesis from Sorting Endosomes Requires the Kinesin Motor KIF13A.

Genome-wide RNAi Screen Identifies SEC61A and VCP as Conserved Regulators of Sindbis Virus Entry.