Penn Medicine Translational
Neuroscience Center (PTNC)

  • PTNC Translational Neuroscience Initiative (TNI)

    PTNC Translational Neuroscience Initiative (TNI)

Translational Neuroscience Initiative (TNI): Funded Projects

To promote greater integration and translation of scientific discoveries for high impact on patient care, the PTNC established the Translational Neuroscience Initiatives (TNIs). The TNIs are designed to catalyze the formation of high-impact teams and promote greater integration between basic laboratory neuroscience, clinical research, and clinical practice. The obvious and immediate benefits of such integration include greater attention by basic neuroscientists to the most pressing clinical issues as well as the opportunity for their research hypotheses to be informed by clinician experience with treatment successes and failures. The anticipated downstream consequence is to create new scientific collaborations and consortia, thereby increasing the rate of translation of discoveries of novel molecular targets and neural systems into therapeutics that transform the care of patients with neuropsychiatric and neurological diseases. Given the excellence of Penn neuroscience investigators and their ability to achieve important, if not dramatic, effects on patient outcomes, resources have been committed to establish at least 4 TNIs at Penn over the next 3 years.

There were two main focus areas targeted for the TNIs:

  1. ​Modulation of neural circuits for preventive health behaviors or recovery from neuropsychiatric or neurological diseases.
  2. Neuroimmune mechanisms and treatment for neuropsychiatric or neurological diseases.

Because of the number of high quality and potentially impactful applications, the PTNC awarded and funded 4 TNI proposals.

Congratulations to the PTNC TNI awardees!

Multi-Sensory Integration: A Neurophysiologic Correlate of Conscious Perception
Collaborators:
Diego Contreras, MD, PhD, Professor, Department of Neuroscience
Brian Litt, MD, Professor, Neurology and Bioengineering
Max B. Kelz, MD, PhD, Associate Professor, Anesthesiology & Critical Care
Andrew R. McKinstry-Wu, MD, Assistant Professor, Anesthesiology & Critical Care
Alexander Proekt, MD, PhD, Assistant Professor, Anesthesiology & Critical Care

COgnitive Neuromodulation/NEtwork Control Translational Science (CONNECTS) Initiative
Collaborators:
Roy H. Hamilton, MD, MS, Assistant Professor of Neurology; Director, Laboratory for Cognition & Neural Stimulation (LCNS)
Danielle S. Bassett, PhD, Skirkanich Assistant Professor of Innovation, Bioengineering, Electrical and Systems Engineering
John Medaglia, PhD, Research Assistant Professor of Psychology & Engineering, Co-Primary Investigator, LCNS
Kelli Williams, PhD, Director of Neuropsychology, Penn Institute of Rehabilitation Medicine

α​-SYN CAR Treatment of Parkinson’s Disease: From Bench to Bedside
Collaborators:
Laura A. Johnson, PhD, Director, Solid Tumor Immunotherapy Laboratory; Adjunct Assistant Professor, Pathology and Laboratory Medicine
Saar Gill, MD, PhD, Assistant Professor of Medicine
Carl H. June, MD, Richard W. Vague Professor in Immunotherapy, Department of Pathology and Laboratory Medicine; Director of the Center for Cellular Immunotherapies; Director of Translational Research at the Abramson Cancer Center
John Q. Trojanowski, MD, PhD, William Maul Measey - Truman G. Schnabel, Jr., M.D. Professor of Geriatric Medicine and Gerontology, Pathology and Laboratory Medicine;  Co-Director, CNDR; Director, IOA; Director, ADCC; Director, Penn Udall Center for Parkinson's Research
Virginia M.-Y. Lee, PhD, John H. Ware 3rd Endowed Professor in Alzheimer's Research, Pathology and Laboratory Medicine; Director, CNDR;  Co-Director, Marian S. Ware Center for Alzheimer's Drug Discovery Program 
Christopher A. Hunter, BSc, PhD, Mindy Halikman Heyer Distinguished Professor of Pathobiology, University of Pennsylvania School of Veterinary Medicine; Chairman, Department of Pathobiology, UPENN

Elucidating Mechanisms of TMS Efficacy in Neuropsychiatric Disorders
Collaborators:
Yvette I. Sheline, MD, McLure Professor of Psychiatry and Behavioral Research; Director, Center for Neuromodulation in Depression and Stress
Michael L. Platt, MD, James S. Riepe University Professor, Professor of Neuroscience, Professor of Psychology, and Professor of Marketing
Desmond J. Oathes, PhD, Assistant Professor of Clinical Psychology in Psychiatry
Joseph W. Kable, PhD, Baird Term Associate Professor of Psychology
Joshua I. Gold, PhD, Professor of Neuroscience; Co-Director, Computational Neuroscience Initiative

 

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