Laboratory of Rare Lung Diseases

William Jester, B.S.

William Jester, BSLaboratory Manager 
University of Pennsylvania Medical Center
Pulmonary, Allergy, & Critical Care Division
Translational Research Laboratories (TRL)
125 South 31st Street, TRL Suite 1200
Philadelphia, PA 19104-3413

(215) 746-2759
wjester@mail.med.upenn.edu

Education: 
B.S., Lebanon Valley College, Annville, Pa

Mr. Jester joined the Airways Biology Initiative (ABI) in 2004. He received his Bachelor of Science degree from Lebanon Valley College. Mr. Jester has over twenty years experience performing and managing basic science research and he is currently serving as ABI's laboratory manager.  The laboratories' current research is focusing on cellular and molecular mechanisms that regulate both airway smooth muscle cell growth and migration.   The laboratories' other interest centers on the investigation of the cytosolic signaling pathways that mediate gene expression and alter myocyte function.

Selected publications

  1. Himes BE, Koziol-White C, Johnson M, Nikolos C, Jester W, Klanderman B, Litonjua AA, Tantisira KG, Truskowski K, MacDonald K, Panettieri RA Jr, Weiss ST. Vitamin D Modulates Expression of the Airway Smooth Muscle Transcriptome in Fatal Asthma. PLoS One. 2015 Jul 24; 10(7):e0134057. eCollection 2015.
  2. Himes BE, Jiang X, Wagner P, Hu R, Wang Q, Klanderman B, Whitaker RM, Duan Q, Lasky-Su J, Nikolos C, Jester W, Johnson M, Panettieri RA Jr, Tantisira KG, Weiss ST, Lu Q. RNA-Seq Transcriptome Profiling Identifies CRISPLD2 as a Glucocorticoid Responsive Gene that Modulates Cytokine Function in Airway Smooth Muscle Cells. PLoS One. 2014 Jun 13;9(6):e99625. eCollection 2014.
  3. Balenga NA, Jester W, Jiang M, Panettieri RA Jr, Druey KM. Loss of regulator of G protein signaling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation. J Allergy Clin Immunol. 2014 Mar 22. [Epub ahead of print]
  4. Hu R, Pan W, Fedulov AV, Jester W, Jones MR, Weiss ST, Panettieri RA Jr, Tantisira K, Lu Q. MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway. FASEB J. 2014 Feb 12. [Epub ahead of print]
  5. Banerjee A, Trivedi CM, Damera G, Jiang M, Jester W, Hoshi T, Epstein JA, Panettieri RA Jr.Trichostatin A abrogates airway constriction, but not inflammation, in murine and human asthma models. Am J Respir Cell Mol Biol. 2012 Feb; 46(2):132-8.
  6. Damera G, Jiang J, Zhao H, Fogle HW, Jester W.F., Freire J, Panettieri Jr. RA. Aclidinium Bromide abrogates allergen-induced hyperresponsiveness and reduces eosinophilia in murine model of airway inflammation.European Journal of Pharmacology, 15; 649(1-3):349-53. 2010
  7. Wang M, Cooper PR, Jiang M, Zhao H, Hui Y, Yao Y, Tate JC, Damera G, Lawson JA, Jester W.F. Jr., Haczku A, Panettieri RA Jr., Fitzgerald GA. Deletion of microsomal prostaglandin E synthase-1 does not alter ozone-induced airway hyper-responsiveness. Journal of Pharmacology and Experimental Therapeutics, 334(1):63-8. 2010
  8. Damera G, Jester W.F., Jiang M, Zhao H, Fogle H.W., Mittelman M, Haczku A, Murphy E, Parikh I, Panettieri Jr. RA. Inhibition of myristoylated alanine-rich C kinase substrate (MARCKS) protein inhibits ozone-induced airway neutrophilia and inflammation. Experimental Lung Research, 36: 67-76. 2010
  9. Damera G, Zhao H, Wang M, Smith M, Kirby C, Jester W.F., Lawson JA, Panettieri Jr. RA. Ozone modulates IL-6 secretion in human airway epithelial and smooth muscle cells. American Journal of Physiology: Lung Cellular and Molecular Physiology, 296(4): 674-83. 2009
  10. Kim JH, Jain D, Tliba O, Yang B, Jester W.F. Jr., Panettieri Jr. RA, Amrani Y, Pure E. TGF-beta potentiates airway smooth muscle responsiveness to bradykinin. American Journal of Physiology: Lung Cellular and Molecular Physiology, 289(4): 511-20. 2005
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