For more news highlights about basic science research at PennMedicine, see the PennMedicine Benchmarks e-newsletter.
- Pancreatic Islet Cell Transplantation Restores Type 1 Diabetes Patients' Ability to Defend Against Life-Threatening Low Blood Sugar, According to Penn Medicine Study
18 Dec 2014
Type 1 diabetes (T1D) patients who have developed low blood sugar (hypoglycemia) as a complication of insulin treatments over time are able to regain normal internal recognition of the condition after receiving pancreatic islet cell transplantation, according to a new study led by researchers at the Perelman School of Medicine at the University of Pennsylvania, published online in Diabetes.
- Penn Medicine Biochemist Receives "Bucket Challenge" Funds to Study Biology of Lou Gehrig's Disease
17 Dec 2014
James Shorter, PhD, an associate professor of Biochemistry and Biophysics at the Perelman School of Medicine at the University of Pennsylvania received a grant from the ALS Association and the Muscular Dystrophy Association (MDA) for research aimed at finding a potential therapy for ALS, or Lou Gehrig's disease.
- Two Penn Professors Named National Academy of Inventors Fellows
17 Dec 2014
Professors James Eberwine, PhD, of the Univeristy of Pennsylcvania’s Perelman School of Medicine and Shu Yang, PhD, of Penn’s School of Engineering and Applied Science, have been named Fellows of the National Academy of Inventors.
- Jason Moore Named Director of the Institute for Biomedical Informatics at Penn Medicine
17 Dec 2014
Jason H. Moore, PhD, has been named the first permanent director of the Penn Institute for Biomedical Informatics (IBI), at the Perelman School of Medicine at the University of Pennsylvania.
- Cutting Out the Cellular Middleman: New Technology Directly Reprograms Skin Fibroblasts For a New Role
16 Dec 2014
As the main component of connective tissue in the body, fibroblasts are the most common type of cell. Taking advantage of that ready availability, scientists from the Perelman School of Medicine at the University of Pennsylvania, the Wistar Institute, Boston University School of Medicine, and New Jersey Institute of Technology have discovered a way to repurpose fibroblasts into functional melanocytes, the body's pigment-producing cells.
- Penn Medicine Study: U.S. Workers Sacrifice Sleep for Work Hours and Long Commutes
12 Dec 2014
Research from the University of Pennsylvania's Perelman School of Medicine published in the December issue of the journal Sleep identifies characteristics and behaviors associated with short sleep that could be targeted to reduce the negative health consequences linked to short sleep.
- Penn Researchers Tame the Inflammatory Response in Kidney Dialysis
11 Dec 2014
New work by Penn researchers has found an effective way to avoid systemic kidney inlammation from frequent dialysis by temporarily suppressing complement during dialysis. Their work appears online in Immunobiology ahead of print.
- Penn Medicine Physician Awarded Top Honor by the Pennsylvania Chapter of the American College of Physicians
11 Dec 2014
Robert K. Cato, MD, chief of the division of General Internal Medicine at Penn Presbyterian Medical Center, has received the Pressman Award for Distinguished Service to Internal Medicine from the Pennsylvania Chapter of the American College of Physicians (PA-ACP).
- Penn Study: Majority of Women with Early-Stage Breast Cancer in U.S. Receive Unnecessarily Long Courses of Radiation
10 Dec 2014
Two-thirds of women treated for early-stage breast cancer in the U.S. receive longer radiation therapy than necessary, according to a new study published in JAMA this week from Penn Medicine researchers Ezekiel J. Emanuel, MD, PhD, and Justin E. Bekelman, MD.
- Penn Medicine Study: No Increase in Patient Deaths or Hospital Readmissions Following Restrictions to Medical Residents' Hours
9 Dec 2014
In the first year after the Accreditation Council for Graduate Medical Education (ACGME) reduced the number of continuous hours that residents can work, there was no change in the rate of death or readmission among hospitalized Medicare patients, according to a new study published in JAMA.
- Simeprevir-Based Therapy Offers Patients in Developing Countries a Cost-Effective Alternative in Treatment of Hepatitis C
9 Dec 2014
Researchers at Penn Medicine, in collaboration with a multi-center international team, have shown that a protease inhibitor, simeprevir, a once a day pill, along with interferon and ribavirin has proven as effective in treating chronic Hepatitis C virus infection (HCV) as telaprevir with interferon and ribavirin, the standard of care in developing countries.
- Penn Medicine Researchers Announce Latest Results of Investigational Cellular Therapy CTL019
8 Dec 2014
The latest results of clinical trials of more than 125 patients testing an investigational personalized cellular therapy known as CTL019 were presented by a University of Pennsylvania research team at the 56th American Society of Hematology Annual Meeting and Exposition.
- People with Mental Illness More Likely To Be Tested for HIV, Penn Medicine Study Finds
4 Dec 2014
People with mental illness are more likely to have been tested for HIV than those without mental illness, according to a new study from a team of researchers at Penn Medicine and the U.S. Centers for Disease Control and Prevention (CDC) published online this week in AIDS Patient Care and STDs.
- Ebola Virus Preparations at The Hospital of the University of Pennsylvania
3 Dec 2014
Preparations for the possibility of caring for a patient with Ebola have been underway for several months at the Hospital of the University of Pennsylvania (HUP).
- Science-Fair Switcheroo, Where Kids Judge the Science
3 Dec 2014
Over 100 third and fourth graders from the Cornerstone Christian Academy, K.W. Reed Christian Academy for Boys, and Beulah Baptist Christian Day School will spend a morning on the University of Pennsylvania campus “judging” hands-on science activities developed by students at Penn, including undergraduate Biological Basis of Behavior program majors and graduate students in neuroscience.
- Brain Activity after Smokers Quit Predicts Chances of Relapsing, Penn Medicine Study Suggests
3 Dec 2014
Reporting in a new study published this week in the journal Neuropsychopharmacology, James Loughead, PhD, associate professor of Psychiatry, and Caryn Lerman, PhD, a professor of Psychiatry and director of Penn’s Center for Interdisciplinary Research on Nicotine Addiction, found that smokers who relapsed within seven days from their target quit date had specific disruptions in the brain’s working memory system during abstinence that separated them from the group who successfully quit.
- Penn Medicine Researchers Named Winners of 2014 Discovery Fast Track Challenge
2 Dec 2014
Three Philadelphia researchers -- Donna George, PhD, and Julia Leu, PhD, both from the Department of Genetics, Perelman School of Medicine at the University of Pennsylvania, and Maureen Murphy, PhD from The Wistar Institute, have been awarded a Discovery Fast Track Challenge grant from GlaxoSmithKline.
- Four Penn Faculty Named to 2014 Class of AAAS Fellows
1 Dec 2014
Four faculty members from the University of Pennsylvania have been named fellows of the American Association for the Advancement of Science (AAAS). Three are from the Perelman School of Medicine and one is from the School of Arts and Sciences.
- Penn Study Points to New Therapeutic Strategy in Chronic Kidney Disease
1 Dec 2014
Chronic kidney disease (CKD) affects at least one in four Americans who are older than 60 and can significantly shorten lifespan. Yet the few available drugs for CKD can only modestly delay the disease’s progress towards kidney failure. Now, however, a team led by researchers at the Perelman School of Medicine at the University of Pennsylvania, has found an aspect of CKD’s development that points to a promising new therapeutic strategy.
- Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts’ Brain Function
26 Nov 2014
Penn Medicine researchers have developed a cognitive test battery, known as Cognition, for the National Space Biomedical Research Institute (NSBRI) to measure the impact of typical spaceflight stressors (like microgravity, radiation, confinement and isolation, exposure to elevated levels of CO2, and sleep loss) on cognitive performance.
- Penn Researchers Identify Protein Elevated in Blood That Predicts Post-Concussion Symptom Severity in Professional Athletes
25 Nov 2014
New Penn Medicine research has found that elevated levels in the blood of the brain-enriched protein calpain-cleaved αII-spectrin N-terminal fragment, known as SNTF, shortly after sports-related concussion can predict the severity of post-concussion symptoms in professional athletes.
- Penn's Aaron T. Beck, MD, Receives Honorary Degree from Australia's La Trobe University
21 Nov 2014
Aaron T. Beck, MD, emeritus professor in the department of Psychiatry at the Perelman School of Medicine at the University of Pennsylvania and the director of Penn's Aaron T. Beck Psychopathology Research Center, was recently awarded an Honorary Doctorate of Science (Honoris Causa) by La Trobe University in Australia.
- Invitation to Cover: Providing a Place to Give Thanks
21 Nov 2014
Since 1994, the Hall-Mercer Community Behavioral Health Center of Pennsylvania Hospital has hosted a Thanksgiving meal. This free event is open to members of the surrounding community, the homeless, and members of the community the Center serves: outpatients living with mental illness or developmental disabilities and their family and friends.
- Penn Researchers Unwind the Mysteries of the Cellular Clock
20 Nov 2014
In the current issue of the journal Cell, Mitchell Lazar, MD PhD, the Sylvan Eisman Professor of Medicine and director of the Institute for Diabetes, Obesity, and Metabolism and his team report the results of a genome-wide survey of circadian genes and genetic regulatory elements called enhancers. These are key parts of the "dark matter" of the genome; rather than encoding proteins, they control the expression of genes.