For more news highlights about basic science research at PennMedicine, see the PennMedicine Benchmarks e-newsletter.
- Penn Medicine Researcher Calls for Changes to Current Colorectal Cancer Screening Guidelines
2 Oct 2015
Screening is the most effective way to reduce the risk of dying from colorectal cancer, yet as a Penn Medicine physician argues in an editorial this week in the journal Gastroenterology, current recommendations to screen older people with a family history of the disease, specifically with colonoscopy every five years, is not justified for most patients.
- International Team of Researchers Co-Led by Penn Aims to Revolutionize Understanding of How Gene Variants Affect Organ Transplant Outcomes
1 Oct 2015
A large international team of transplant surgeons and scientists, co-led by researchers from the Perelman School of Medicine at the University of Pennsylvania, has come together to investigate the genetic factors behind transplant successes and failures.
- Penn Medicine Researcher Receives Champion of Hope Award
1 Oct 2015
David Fajgenbaum, MD, MBA, MSc, a research assistant professor of Medicine, division of Hematology/Oncology, in the Perelman School of Medicine at the University of Pennsylvania, has received the RARE Champion of Hope award for science.
- Penn-developed, DNA-based Vaccine Clears Nearly Half of Precancerous Cervical Lesions in Clinical Trial
30 Sep 2015
Using a novel synthetic platform for creating vaccines originally developed in the laboratory of David Weiner, PhD, a professor of Pathology and Laboratory Medicine from the Perelman School of Medicine at the University of Pennsylvania, a team led by his colleagues at the Johns Hopkins University School of Medicine, has successfully eradicated precancerous cervical lesions in nearly half of the women who received the investigational vaccine in a clinical trial.
- Invitation to Cover: Racing Against the Clock, 4th Annual Penn 5K for the IOA Raises Research Funds for Institute on Aging
18 Sep 2015
This Sunday, the 4th annual 5K for The IOA and Memory Mile Walk will be held in support of the Institute on Aging (IOA) at the University of Pennsylvania.
- Researchers at Penn Medicine and the Department of Veterans Affairs Investigate Chronic Illnesses in 200,000 Veterans
17 Sep 2015
Two groups of investigators at Penn Medicine received funding from the Department of Veterans Affairs (VA) to beta-test the genetic database of 200,000 veterans in the VA’s Million Veterans Program (MVP).
- Cancer Doesn't Sleep: The Myc Oncogene Disrupts Circadian Rhythm and Metabolism in Cancer Cells, Finds New Penn Study
17 Sep 2015
Myc is a cancer-causing gene responsible for disrupting the normal 24-hour internal rhythm and metabolic pathways in cancer cells, found a team led by researchers from the Perelman School of Medicine at the University of Pennsylvania.
- Penn Team Pinpoints Immune Changes in Blood of Melanoma Patients on PD-1 Drugs That Put Potential Biomarker within Reach
16 Sep 2015
A simple blood test can detect early markers of “reinvigorated” T cells and track immune responses in metastatic melanoma patients after initial treatment with the anti-PD-1 drug pembrolizumab, researchers from the Abramson Cancer Center of the University of Pennsylvania report in new research being presented at the inaugural CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference.
- Multiple Myeloma Patients More Vulnerable to 'Financial Toxicity' Due to Expensive, Longer Courses of Treatments, Penn Study Finds
16 Sep 2015
Even patients with health insurance who have multiple myeloma may be vulnerable to "financial toxicity" because of the higher use of novel therapeutics and extended duration of myeloma treatment, researchers from Penn's Abramson Cancer Center report in this week's Lancet Haematology.
- Penn Study Demonstrates Genes' Major Role in Skin and Organ Development
15 Sep 2015
Knocking out one or both crucial regulatory genes caused cleft lip, skin barrier defects, and a host of other developmental problems in mice, according to new research from the Perelman School of Medicine at the University of Pennsylvania, hinting that abnormalities in these molecular pathways could underlie many birth defects that are presently not well understood.
- Blood Cancers Develop When Immune Cell DNA Editing Enzyme Hits Off-target Spots in the Genome, Penn Animal Study Finds
10 Sep 2015
Now, researchers from the Perelman School of Medicine, University of Pennsylvania have shown that when the enzyme key to cutting and pasting segments of DNA hits so-called "off-target" spots on a chromosome, the development of immune cells can lead to cancer in animal models.
- Sensitivity of Smell Cilia Depends on Location and Length in Nasal Cavity, Penn Researchers Find
10 Sep 2015
A team of researchers from the Perelman School of Medicine at the University of Pennsylvania found a location-dependent pattern in cilia length in the mouse nasal cavity that affects sensitivity to odors. The discovery may also have important implications for the study of sight and touch.
- Penn Researchers Report Sustained Remission After Treatment with Investigational Personalized Cellular Therapy In Patient with Multiple Myeloma
9 Sep 2015
A multiple myeloma patient whose cancer had stopped responding after nine different treatment regimens experienced a complete remission after receiving an investigational personalized cellular therapy known as CTL019 developed by a team at the University of Pennsylvania.
- Paying Women to Have Mammograms Is Unethical, Penn Medicine Ethicist Says
9 Sep 2015
The widespread practice of incentivizing mammogram completion via cash payments is unethical according to a Viewpoint article published this week in JAMA by an expert from the Perelman School of Medicine at the University of Pennsylvania.
- Penn's Abramson Cancer Center Earns "Exceptional" Rating by the National Cancer Institute
3 Sep 2015
The University of Pennsylvania’s Abramson Cancer Center (ACC) has received an “exceptional” rating by the National Cancer Institute during an extensive peer-review process for its five-year competitive research support grant. The rating is the highest possible for an NCI cancer center.
- Team Decodes Structure of Protein Complex Active in DNA Repair
3 Sep 2015
A team led by Roger Greenberg, MD, PhD, an associate professor of Cancer Biology at Penn, and Frank Sicheri, PhD, in Toronto, report online in Molecular Cell ahead of print, the atomic structures of several BRCC36-containing complexes.
- Abramson Cancer Center Researchers Report Long-Term Remissions in First Group of Patients to Receive Personalized Cellular Therapy for Chronic Lymphocytic Leukemia
2 Sep 2015
Eight of 14 patients in the first trial of the University of Pennsylvania’s personalized cellular therapy for chronic lymphocytic leukemia (CLL) responded to the therapy, with some complete remissions continuing past four and a half years.
- Mutation in Well-studied p53 Tumor Suppressor Protein Uses Epigenetic Pathways to Drive Aggressive Cancer Growth
2 Sep 2015
Aggressive cancer growth and alterations in gene activity without changes in DNA sequence (epigenetics) are associated with mutant p53 proteins, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
- Penn Medicine's Rinad Beidas, PhD, Receives 'President's New Researcher Award' from the Association for Behavioral and Cognitive Therapies (ABCT)
1 Sep 2015
Acupuncture may be a viable treatment for women experiencing hot flashes as a result of estrogen-targeting therapies to treat breast cancer, according to a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania.
- Penn Study Suggests Acupuncture Dramatically Reduces Hot Flashes in Breast Cancer Survivors
1 Sep 2015
Eight of 14 patients in the first trial of the University of Pennsylvania's personalized cellular therapy for chronic lymphocytic leukemia (CLL) responded to the therapy, with some complete remissions continuing past four and a half years.
- Penn Medicine Hospitals Recognized Among First Approved "Leaders in LGBT Healthcare Equality" by Human Rights Campaign in 2015
31 Aug 2015
The Hospital of the University of Pennsylvania, Pennsylvania Hospital, Penn Presbyterian Medical Center, and Chester County Hospital were announced among the 2015 class of the Human Rights Campaign (HRC) Foundation’s “Leader in LGBT Healthcare Equality” list, and the first to be announced in the organization’s rolling admissions in 2015.
- Penn Medicine Researchers Receive Kaufman Foundation Awards
27 Aug 2015
University of Pennsylvania researchers will receive five of the 10 grants being awarded this year by the Charles E. Kaufman Foundation, part of The Pittsburgh Foundation, which supports cutting-edge scientific research in chemistry, biology, and physics at institutions across Pennsylvania. Two of those five will go to researchers from the Perelman School of Medicine.
- Penn Medicine Study: Brexpiprazole Provides New Second-Line Treatment Options for Patients with Major Depressive Disorder
26 Aug 2015
Brexpiprazole, an antipsychotic drug approved this summer by the U.S. Food and Drug Administration, is an effective and well-tolerated addition to conventional first-line antidepressants for the treatment of major depressive disorder (MDD), according to research from psychiatrists in the Perelman School of Medicine at the University of Pennsylvania.
- Use of Observation Stays Over Hospital Admissions Drives Up Costs for One in Four Medicare Patients, Penn Study Finds
26 Aug 2015
In the midst of a growing trend for Medicare patients to receive observation care in the hospital to determine if they should be formally admitted, a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania shows that for more than a quarter of beneficiaries with multiple observation stays, the cumulative out-of-pocket costs of these visits exceeds the deductible they would have owed for an inpatient hospital admission.