For more news highlights about basic science research at PennMedicine, see the PennMedicine Benchmarks e-newsletter.
- Penn Medicine Study Shows Menopause Does Not Increase or Create Difficulty Sleeping
28 Jan 2015
Women in their late thirties and forties who have trouble sleeping are more than three times more likely to suffer sleep problems during menopause than women who have an easier time getting shut-eye, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania.
- Study Reveals Possible Therapeutic Target for Common, But Mysterious Brain Blood Vessel Disorder
26 Jan 2015
Tens of millions of people around the world have abnormal, leak-prone sproutings of blood vessels in the brain called cerebral cavernous malformations (CCMs). These abnormal growths can lead to seizures, strokes, hemorrhages, and other serious conditions, yet their precise molecular cause has never been determined. Now, cardiovascular scientists at the Perelman School of Medicine at the University of Pennsylvania have studied this pathway in heart development to discover an important set of molecular signals, triggered by CCM-linked gene defects, that potentially could be targeted to treat the disorder.
- Penn Medicine Opens Pavilion for Advanced Care, Integrating Critical Care Specialties and Expanding Penn Presbyterian Medical Center Campus
22 Jan 2015
This month, Penn Medicine's new 144 million-dollar facility, the Pavilion for Advanced Care (PAC) at Penn Presbyterian Medical Center (PPMC), opened the doors to its first patients. Clinical teams from critical care specialties, surgical services, trauma/emergency services and radiology have come together in the new six-story, 178,000-square-foot facility.
- Medicaid "Fee Bump" to Primary Care Doctors Associated with Better Access to Appointments, According to Penn Study
22 Jan 2015
The increase in Medicaid reimbursement for primary care providers, a key provision of the Affordable Care Act (ACA), was associated with a 7.7 percentage points increase in new patient appointment availability without longer wait times, according to results of a new 10-state study.
- Penn Study Uncovers Secrets of a Clump-Dissolving Protein
22 Jan 2015
Penn Medicine researchers have discovered that a previously disregarded part of the Hsp104 structure, the N-terminal domain (NTD), located at one end of the Hsp104 molecule, is a major player in its protein-busting powers.
- Penn Medicine Selected for Digital 25 Award by IDG Enterprise Media
22 Jan 2015
Penn Medicine received a 2015 Digital Edge 25 Award, produced by IDG Enterprise media brands CIO and Computerworld and the CIO Executive Council. One of 25 recipients nationwide, Penn Medicine is the only academic medical center on the list.
- Mutated ATRX Gene Linked to Brain and Pancreatic Neuroendocrine Tumors is Potential Biomarker for Rare Adrenal Tumors Too
21 Jan 2015
A somatic mutation in the ATRX gene has recently been shown as a potential molecular marker for aggressive brain tumors, such as gliomas, neuroblastomas and pancreatic neuroendocrine tumors. Now, for the first time, researchers at the Perelman School of Medicine at the University of Pennsylvania have found that the same mutated gene may serve as a much-needed biomarker for the pheochromocytomas and paragangliomas (PCC/PGL) that become malignant.
- Penn Medicine Bioethicists Call for Return to Asylums for Long-Term Psychiatric Care
20 Jan 2015
A new viewpoint in JAMA,written by Dominic Sisti, PhD, Andrea Segal, MS, and Ezekiel Emanuel, MD, PhD, of the department of Medical Ethics and Health Policy in the Perelman School of Medicine at the University of Pennsylvania, looks at the evolution away from inpatient psychiatric beds, evaluates the current system for housing and treating the mentally ill, and then suggests a modern approach to institutionalized mental health care as a solution.
- Penn Medicine Researchers Discover Possible New General Anesthetics
20 Jan 2015
Penn Medicine researchers, in a continuation of their groundbreaking work to better understand how anesthesia works in the body, have found the first new class of novel anesthetics since the 1970s.
- Center for Retinal and Ocular Therapy at Penn Expands Relationship with Spark Therapeutics to Develop Potential Treatments for Rare, Blinding Conditions
20 Jan 2015
The University of Pennsylvania has announced an expanded relationship with Spark Therapeutics, a late-stage gene therapy company developing treatments for debilitating, genetic diseases.
- Penn Medicine Researcher to Receive National Award from the American College of Physicians
15 Jan 2015
Beatrice H. Hahn, MD, a professor of Medicine and Microbiology at the Perelman School of Medicine at the University of Pennsylvania, will receive the American College of Physicians Award for Outstanding Work in Science as Related to Medicine by the American College of Physicians (ACP), the national organization of internists.
- Penn Medicine Study: Endobronchial Forceps Effective in Retrieval of Tip-Embedded Inferior Vena Cava (IVC) Filters
14 Jan 2015
A Penn Medicine study published this week in the journal Radiology confirms that an endobronchial forceps technique the research group developed is a safe and highly effective option for many patients seeking IVC filter removal.
- Penn Medicine Cancer Biologist Recipient of a 2015 Harrington Scholar-Innovator Award for Physician-Scientists
14 Jan 2015
The Harrington Discovery Institute at University Hospitals in Cleveland, Ohio, has given Xianxin Hua, MD, PhD, a professor of Cancer Biology at the Perelman School of Medicine at the University of Pennsylvania, one of 11 Harrington Scholar-Innovator Awards.
- Life at Higher Elevation Linked to Lower Incidence of Lung Cancer, Penn Study Suggests
14 Jan 2015
Lung cancer rates in both smokers and non-smokers are lower in higher-elevation counties in the western part of the United States, suggesting that oxygen may promote the incidence of lung cancer, according to a new study co-authored by a student at the Perelman School of Medicine at the University of Pennsylvania.
- Penn Medicine Experts Urge Expansion of Federal Incentives to Improve Patient Care Quality and Safety
13 Jan 2015
National attempts to help prevent clinical “never events” – a group of complications of hospital care that are often preventable – should focus not only on reducing these specific events, but should also focus on improving infrastructures within health care institutions necessary to support quality improvement and patient safety more broadly, say two experts from the Perelman School of Medicine at the University of Pennsylvania.
- Penn Medicine Study: Web-based TAVR Marketing Found to Overstate Benefits, Understate Risks
12 Jan 2015
While a boon for many patients who would not have been a candidate for conventional surgery, Penn Medicine researchers have discovered that marketing for TAVR does not accurately portray the risks associated with undergoing the procedure. Their analysis is available in the January 12 issue of JAMA Internal Medicine.
- Patch or Pills: How Quickly Smokers Metabolize Nicotine May Point to Most Effective Way to Quit, Penn Study Finds
12 Jan 2015
In a first-of-its-kind randomized clinical trial, researchers from Penn Medicine and collaborators have shown that the most-suited treatment for each smoker may depend on how quickly they metabolize the nicotine in their body after quitting.
- Wearable Tracking Devices Alone Won't Drive Health Behavior Change, According to Penn Researchers
8 Jan 2015
New Year’s weight loss resolutions are in full swing, but despite all the hype about the latest wearable tracking devices, there’s little evidence that this technology alone can change behavior and improve health for those that need it most, according to a new online-first viewpoint piece in JAMA.
- Penn Study: Radiation Plus Hormone Therapy Prolongs Survival for Older Men with Prostate Cancer
6 Jan 2015
Adding radiation treatment to hormone therapy saves more lives among older men with locally advanced prostate therapy than hormone therapy alone, according to a new study in the Journal of Clinical Oncology this week from Penn Medicine researchers.
- Overly Conservative FDA Label Likely Prevents Use of Metformin in Many Type 2 Diabetics
5 Jan 2015
Many patients with type 2 diabetes in the United States may be discouraged from taking metformin—a proven, oral diabetes medicine—because the U.S. Food and Drug Administration inappropriately labels the drug unsafe for some patients also suffering from kidney problems, researchers from Penn Medicine and Weill Cornel Medical College report this week in a research letter published in JAMA Internal Medicine.
- Penn Receives Grants to Forward Blindness Research; Penn Researcher Receives Innovation Award
23 Dec 2014
Penn Medicine’s department of Ophthalmology has been awarded a 115,000-dollar grant from Research to Prevent Blindness to support research into the causes, treatment and prevention of blinding diseases.
- Pancreatic Islet Cell Transplantation Restores Type 1 Diabetes Patients' Ability to Defend Against Life-Threatening Low Blood Sugar, According to Penn Medicine Study
18 Dec 2014
Type 1 diabetes (T1D) patients who have developed low blood sugar (hypoglycemia) as a complication of insulin treatments over time are able to regain normal internal recognition of the condition after receiving pancreatic islet cell transplantation, according to a new study led by researchers at the Perelman School of Medicine at the University of Pennsylvania, published online in Diabetes.
- Penn Medicine Biochemist Receives "Bucket Challenge" Funds to Study Biology of Lou Gehrig's Disease
17 Dec 2014
James Shorter, PhD, an associate professor of Biochemistry and Biophysics at the Perelman School of Medicine at the University of Pennsylvania received a grant from the ALS Association and the Muscular Dystrophy Association (MDA) for research aimed at finding a potential therapy for ALS, or Lou Gehrig's disease.
- Jason Moore Named Director of the Institute for Biomedical Informatics at Penn Medicine
17 Dec 2014
Jason H. Moore, PhD, has been named the first permanent director of the Penn Institute for Biomedical Informatics (IBI), at the Perelman School of Medicine at the University of Pennsylvania.