For more news highlights about basic science research at PennMedicine, see the PennMedicine Benchmarks e-newsletter.
- "Mild Traumatic Brain Injury an Oxymoron:" New Protein Biomarker Highlights Damaged Brain Wiring After Concussion, Finds Penn Study
23 Nov 2015
Physicians and others now recognize that seemingly mild, concussion-type head injuries lead to long-term cognitive impairments surprisingly often. A brain protein called SNTF, which rises in the blood after some concussions, signals the type of brain damage that is thought to be the source of these cognitive impairments, according to a study led by researchers from the Perelman School of Medicine at the University of Pennsylvania, and the University of Glasgow, Glasgow, UK.
- Yoga Helps Maintain Quality of Life, May Lessen Side Effects in Men Undergoing Prostate Cancer Treatment
16 Nov 2015
Men with prostate cancer who are undergoing radiation therapy can benefit from yoga, researchers at the Perelman School of Medicine at the University of Pennsylvania reported at the Society of Integrative Oncology’s 12th International Conference.
- Nearly Half of Hepatitis C Patients on Medicaid Denied Coverage for Life-Saving Drugs, Penn Researchers Report
16 Nov 2015
Nearly 50 percent of Medicaid patients infected with chronic hepatitis C whose doctors had prescribed newer, life-saving antiviral drugs were denied coverage to the therapies because they weren't considered “a medical necessity” or because the patients tested positive for alcohol/drugs, among other reasons, according to new Penn Medicine research.
- 'Taste Bud' Biomarker Forecasts Better Post-Surgery Results for Some Chronic Sinusitis Patients
16 Nov 2015
A simple taste test can identify patients who will have highly successful sinus surgery, researchers from Penn Medicine and the Monell Chemical Senses Center report.
- Adults with OCD Can Benefit from Exposure Therapy When Common Drug Treatment Options Fail, Penn Study Finds
11 Nov 2015
Patients with Obsessive-Compulsive Disorder (OCD) can improve their symptoms significantly by adding exposure and response prevention therapy to their treatment regimen when common drug treatment options have failed, according to new research from psychiatrists at the Perelman School of Medicine at the University of Pennsylvania.
- Penn Researchers Present Findings on Cardiac Risks for Patients with Chronic Kidney Disease
10 Nov 2015
Chronic Kidney Disease (CKD), which afflicts more than 26 million Americans, is a condition in which individuals experience a slow loss of kidney function over time. At the American Heart Association Scientific Sessions 2015, researchers from the Perelman School of Medicine at the University of Pennsylvania today presented findings from their analysis of the Chronic Renal Insufficiency Cohort (CRIC) study to evaluate risk markers for adverse cardiac events in patients with CKD.
- Researchers Compare Two-Year Clinical Outcomes of Mitral Valve Replacement and Repair in Treating Severe Valve Regurgitation
9 Nov 2015
In a study presented today at the American Heart Association Scientific Sessions 2015 and published in this week's issue of the New England Journal of Medicine, researchers from the Perelman School of Medicine at the University of Pennsylvania, in partnership with other institutions in the Cardiothoracic Surgical Trials Network (CTSN), found that recipients of a mitral valve replacement for IMR experienced a lower rate of heart failure and fewer cardiovascular-related hospital readmissions in the two years following surgery.
- Penn Study Asks: To Improve Patients' Health, Should you Pay Physicians, Patients, or Both
8 Nov 2015
Providing financial incentives to both primary care physicians and patients leads to a greater reduction in low-density lipoprotein (LDL) cholesterol in patients than paying only the physician or only the patient, according to a new study led by researchers at the Perelman School of Medicine at the University of Pennsylvania.
- Video-Based CPR Training May be as Valuable as Hands-On Approach, Penn Study Finds
8 Nov 2015
Using a video to train family members of patients at risk for cardiac arrest in CPR may be just as effective as using the traditional hands-on method with a manikin, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
- In First Real-World Example, Penn Study Shows Mechanical and Manual CPR Produce Equivalent Survival Rates for Cardiac Arrest Patients
8 Nov 2015
Mechanical CPR, in which a device is used by Emergency Medical Service (EMS) providers to deliver automated chest compressions during cardiac arrest resuscitation care, is associated with an equivalent survival rate for patients experiencing cardiac arrest outside of the hospital as manual CPR, according to new findings from a team of researchers at the Perelman School of Medicine at the University of Pennsylvania.
- FIGHT Study Proves Type-2 Diabetes Therapy Ineffective in the Treatment of High-Risk Heart Failure Patients
8 Nov 2015
In an attempt to correct defects in the energy generation that contributes to poor pump function among heart failure patients, researchers examined whether the diabetes drug liraglutide, could improve the condition of patients with advanced heart failure.
- Penn Prevention Research Center Receives $1.4 Million from the Centers for Disease Control and Prevention for New Research Initiatives
6 Nov 2015
The University of Pennsylvania Prevention Research Center (PRC) has received $1.4 million from the Centers for Disease Control and Prevention (CDC) for three new Special Interest Projects (SIPs).
- Transparent Zebrafish Reveal How Axons Regenerate on a Proper Path, Finds Penn Study
5 Nov 2015
Using a transparent zebrafish model, researchers from the Perelman School of Medicine at the University of Pennsylvania, have identified key components of a mechanism that allows the nervous system to heal itself.
- Evidence-based Practice Model Can Help Hospitals Crunch Data to Deliver Best Care, Cut Costs, and Reduce Hospital Error
4 Nov 2015
Amid continued pressures to minimize errors and cut costs, hospitals are continuing to scramble to find solutions to problems plaguing health systems nationwide. A possible solution to many of those issues can be found in hospital evidence-based practice centers (EPCs), says a new Penn Medicine study suggesting EPCs can effectively inform decision-making in medical settings.
- Brain's Hippocampus is Essential Structure for All Aspects of Recognition Memory, Penn Medicine Researchers Find
3 Nov 2015
The hippocampus, a brain structure known to play a role in memory and spatial navigation, is essential to one’s ability to recognize previously encountered events, objects, or people – a phenomenon known as recognition memory – according to new research from the departments of Neurosurgery and Psychology in the Perelman School of Medicine at the University of Pennsylvania.
- Penn Scientists Reveal 90 Percent of Skin-Based Viruses Represent Viral "Dark Matter"
2 Nov 2015
Scientists in recent years have made great progress in characterizing the bacterial population that normally lives on human skin and contributes to health and disease. Now researchers from the Perelman School of Medicine at the University of Pennsylvania have used state-of-the-art techniques to survey the skin’s virus population, or “virome.” The study, published in the online journal mBio last month, reveals that most DNA viruses on healthy human skin are viral “dark matter” that have never been described before.
- Penn Neurosurgeon Gordon Baltuch, MD, Performs 1,000th Deep Brain Stimulation Surgery
30 Oct 2015
Deep brain stimulation (DBS) improves many of the motor symptoms of Parkinson’s disease (PD) and is a life-alerting surgery for many patients. Penn Medicine’s Gordon Baltuch, MD, a professor of Neurosurgery and director of the Penn Center for Functional and Restorative Neurosurgery, is one of the most prolific DBS surgeons in the world, having recently performed his 1,000th procedure, marking an important milestone for Baltuch and Penn Medicine.
- Study Reveals How to Regenerate Mouse Ears Without a Scar
30 Oct 2015
In contrast to amphibian tissue regeneration, traumatic injuries in mammals typically heal with a fibrous scar. Researchers discovered that some strains of mice heal without a scar, by disrupting a protein, called Sdf1, that normally recruits white blood cells to sites of injury.
- Penn Medicine Nurse Selected as American Academy of Nursing Fellow
29 Oct 2015
Barbara Ann Todd, DNP, CRNP, ACNP-BC, FAANP, director of advanced practice in the department of Nursing and director of the Graduate Nurse Education demonstration project at the Hospital of the University of Pennsylvania, has been inducted as a Fellow in the American Academy of Nursing (AAN).
- Exercise Could Provide a Margin of Safety for Women Who Want to Delay Preventive Mastectomy, Penn Study Shows
29 Oct 2015
Regular physical activity could play a role in helping women at high-risk of breast cancer delay the need for drastic preventive measures such as prophylactic mastectomy, according to new research led by the Perelman School of Medicine at the University of Pennsylvania.
- Autophagy Works in Cell Nucleus to Guard Against Start of Cancer, Finds Penn Study
28 Oct 2015
Autophagy, literally self-eating or the degradation of unwanted cellular bits and pieces by the cell itself, has been shown for the first time to also work in the cell nucleus. In addition, in this setting it plays a role in guarding against the start of cancer, according to new research from the Perelman School of Medicine at the University of Pennsylvania.
- Penn Medicine Researchers Receive NIH Grant to Promote Sex and Gender Studies in Health
28 Oct 2015
The National Institutes of Health (NIH) Office of Research on Women's Health (ORWH) has awarded funding to two researchers at Penn Medicine to lead a career development program for junior investigators interested in pursuing women's health and sex differences research.
- Marital Status Linked to Better Functional Outcomes Following Cardiac Surgery, Penn Medicine Study Finds
28 Oct 2015
Patients who are divorced, separated or widowed had an approximately 40 percent greater chance of dying or developing a new functional disability in the first two years following cardiac surgery than their married peers, according to a new study from researchers at the Perelman School of Medicine at the University of Pennsylvania published in this week’s JAMA Surgery.
- Two Researchers from Penn's Perelman School of Medicine Elected to American Academy of Arts and Sciences
28 Oct 2015
Two researchers from the Perelman School of Medicine at the University of Pennsylvania have been elected as new members to the American Academy of Arts and Sciences, one of the nation's most prestigious honorary societies and a leading center for independent policy research.