Perelman School of Medicine at the University of Pennsylvania
Center for Resuscitation Science

Research

Current/Past Research



Becker, Lance

Current

NIH K-12 (Becker Strom) 7//01/11-6/30/16

Enabling medical research growth in emergency medicine

Major Goal:

  1. To train emergency medicine clinical scholars in clinical trials methodology related to cardivascular emergencies.
NIH-RO1 (Becker) 6/17-10-4/30/15

Optimizing heart and brain cooling during cardiac arrest

Major Goals

  1. To develop new slurry generation prototypes, using supercooled saline, that will be transportable to the experimental labs and capable of producing ice-slurries with >45% ice percentage at a rate of >250ml per minute
  2. To map the temperature changes in the body and brain using the two novel cooling methods and relate these to standard cooling techniques under differing conditions of blood flow to understand the compartmentalized thermo-kinetics of differing cooling methods
  3. To provide important scientific data on the optimal timing for cooling. Specifically we will determine whether, following a prolonged period of ischemia, it is better to first prioritze cooling or ROSC.
Medtronic Foundation (Becker) 7/01/10-6/30/15

Heart Rescue Prime – Phase 2

Major Goal:

  1. To increase the measurable state-wide survival rate from sudden cardiac arrest by 50%.
Abbott (Becker) 10/09/09-4/30/13

Integrating POC testing into ED triage with I-STAT

Major Goals:

  1. Assess feasibility of performing POC laboratory testing in the ED triage area using i-STAT in ED patients who are triaged as Level 2-4 in three ED's.
  2. Determine the prevalence of abnormal laboratory results for patients who receive triage POC testing.
  3. Assess the proportion of cases in these groups where triage POC laboratory results change triage levels or expedited immediate care for patients traiged at level 2-4.
Zoll Medical 5/01/11-5/01/13

Understanding the impact of chest recoil on CPR generated blood flow: Preliminary study

Major Goal:

  1. Using the ZOLL device for computer controlled compression delivery, the Penn investigators will measure changes in hemodynamic parameters during CPR (blood pressure, coronary perfusion pressures, etc), while varying the upstroke of decompression phase of chest compression during CPR.
Benechill 1/01/12-12/31/13

Use of the Rhinochill System to Improve Patient Survival in Cardiac Arrest in the Pre-Hospital Setting

Major Goal:

  1. To demonstrate in multiple pre-hospital systems in the United States, the safety and feasibility of using RhinoChill in the pre-hospital setting, prior to establishment of return spontaenous circulation (ROSC), as an effective means of performing "intra-arrest cooling" and improving rates of neurologicaly favorable hospital discharge rates.
NIH-R18 (Abella) 8/18/11-7/31/15

Implementation of cardiopulmonary resuscitation training for at-risk families

Major Goals:

  1. Test two CPR training strategies via hospital-based CPR training dissemination.
  2. Measure the barriers/motivations to CPR training among potential subjects.
  3. Perform a budget impact analyisis on the direct costs of hospital-based VSI CPR training from a payer's perspective.

Abella, Benjamin

Current

Doris Duke Clinical Scientist Development Award 8/09-7/12

Quality of cardiac arrest resuscitation care and its effects on post-reperfusion pathophysiology
The goal of this project is to evaluate the time course of neutrophil activation and other immunologic biomarkers after initial resuscitation from cardiac arrest.

NIH/NHLBI R18 8/11-7/15

Dissemination and Implementation grant – Implementation of cardiopulmonary resuscitation training for at-risk families
The goal of this work is to evaluate methods of broad dissemination of CPR skills to the lay public using Video self-instruction CPR training kits.

NIH/NHLBI K23 8/06-7/11

Career Development Award – Cardiac Arrest: Improving Resuscitation Quality and Outcomes
The goal of this clinical research is to evaluate resuscitation performed by hospital personnel during cardiac arrest, and to assess the role of automated feedback.

Past

Philips Healthcare Research Grant 8/09-7/11

Advancements in Cardiopulmonary Resuscitation and Emergency Care during Hemodynamic Crisis
The goal of this work is to evaluate use interface data and human factors during use of monitor/defibrillators during in-hospital cardiac arrest.


Berg, Robert

Current

NICHD-HD063108 12/1/09 -11/30/14

Collaborative Pediatric Critical Care Research Network (U10) – Pediatric Critical Care Research Network at Children's Hospital of Philadelphia
The goal of this project is state-of-the-art clinical investigations of pediatric critical care though this NICHD-funded multi-institutional clinical research network.

HD049934 (Dean) 12/1/09-11/30/14

Collaborative Pediatric Critical Care Research Network Core Data Project
The goal of this multi-center epidemiological evaluation of children admitted to NICHD-funded Collaborative Pediatric Critical Care Research Network ICUs is to describe and categorize these children in order to better understand the diagnoses, treatments, and outcomes of critically ill children.

Past

HD049934 (Dean) 12/1/09-11/30/10

Collaborative Pediatric Critical Care Research Network Variations in Pediatric Sever Asthma Care
The goal of this multi-center epidemiological evaluation of pediatric asthma care is to assess the variability of care among the NICHD-funded 7 Collaborative Pediatric Critical Care Research Network ICUs and ultimately to plan a multi-center interventional trial.

HD049934 (Dean) 12/1/09-11/30/10

Collaborative Pediatric Critical Care Research Network – Critical Pertussis: A Prospective Cohort Study
The goal of this multi-center epidemiological evaluation of critical pertussis is to describe the largest cohort of critically ill children admitted to a PICU for pertussis. The population includes the NICHD-funded 7 Collaborative Pediatric Critical Care Research Network ICUs, and a larger network of collaborating PICU.


Nadkarni, Vinay M.

Current

5R01HL058669-10 (Pastuszko) 7/1/09-6/30/14

HIH/NINDS – Brain Metabolism and Neuroprotection in Cardiopulmonary Bypass
The goal of this project is to study the mechanisms responsible for Deep Hypothermic Cardiac Arrest-associated neuronal injury and neuroprotection by GCSF, topiramate, and hypothermia.

1U01HL094345-01 (Moler) 10/1/08-9/30/13

NIH/NHLBI – THAPCA Trials – Scientific Application
The goal of this project is to evaluate the clinical efficacy of therapeutic hypothermia to improve survival and neurologic outcome after cardiac arrest.

CIHR 2009-09-15 (Parshuram) 7/1/10-6/30/14

Canadian Institute of Health Research – The Bedside Paediatric Early Warning System (BPEWS)
The goal of this project is to evaluate the impact of Bedside Paediatric Early Warning System (PEWS) implementation in 34 pediatric hospitals in Canada, US, UJ on processes and efficiency of care, survival and acquired morbidity.

Center of Excellence Grant (Hunt) 9/1/10-8/31/13

Laerdal Foundation for Acute Care Medicine (non-profit) EXPRESS collaborative
The goal of this project is to improve the delivery of medical care to critically ill children by answering important research questions pertaining to pediatric resuscitation, education and simulation.

Corporate Sponsor Agreement 1/1/11-12/31/11

Laerdal Medical Corporation – Quantitative Measurement of CPR during IN-Hospital Pediatric Cardiac Arrest
The goal of this project is to study the quality of mechanisms of CPR in infants and children.

Center of Excellence Grant 1/1/10-12/31/12

Laerdal Foundation for Acute Care Medicine (non-profit) – Science of Simulation Education, Implementation, and Dissemination
The goal of this project is to develop, implement, analyze, and refine novel simulation strategies