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The Ridky Lab

Research Program: Targeted Therapeutics

Experimental efforts in the lab are designed with the ultimate goal of advancing progress in the application of targeted, rationally designed, molecular therapeutics for human cancer. The genetically-defined, engineered human cancer models are being used to systematically elucidate proteins required for carcinogenesis and to test their potential role as therapeutic targets.  Potential targets are indentified through various bioinformatics approaches based on both the engineered models, and also on spontaneous human tumors from patients.  Of particular interest are potential targets either excreted into the tumor microenvironment or expressed on the surface of the tumor or stromal cells, as these are ideal targets for antibody-mediated therapy to interfere with tumor progression. The organotypic tissue platform has proved useful for screening panels of small molecule inhibitors, and in vivo experiments targeting pathways indentified in these screens are currently underway.

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University of Pennsylvania | Perelman School of Medicine