The Ridky Lab

Selected Publications

Ridky T.W., Chow, J.M., Wong, DJ, and Khavari, P.A. (2010) Invasive 3-Dimensional Organotypic Neoplasia from Multiple Normal Human Epithelia. Nat Med. 2010 Nov 21. [Epub ahead of print]

Ridky T.W., Khavari PA. (2010) The hair follicle bulge stem cell niche resists transformation by the hedgehog pathway.  Cell Stem Cell. Apr 2;6(4):292-4.

Rieger KE, Ridky TW, Sundram UN. (2010) Skin nodules in a patient with acute myeloid leukemia and neurological deterioration--quiz case. Disseminated fusariosis. Arch Dermatol. Sep;146(9):1037-42.

Rinn JL, Wang JK, Allen N, Brugmann SA, Mikels AJ, Liu H, Ridky TW, Stadler HS, Nusse R, Helms JA, Chang HY. (2008) A dermal HOX transcriptional program regulates site-specific epidermal fate. Genes Dev.Feb 1;22(3):303-7.

Wong DJ, Liu H, Ridky TW, Cassarino D, Segal E, Chang HY. (2008) Module map of stem cell genes guides creation of epithelial cancer stem cells. Cell Stem Cell. Apr 10;2(4):333-44.

Ridky T.W.  (2007) Nonmelanoma Skin Cancer: Periodic Synopsis. J. American Acad. Dermatol. J Am Acad Dermatol. 2007 Sep;57(3):484-501.

Zhang JY, Adams AE, Ridky TW, Tao S, Khavari PA. (2007) Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia. Cancer Res. Apr 15;67(8):3827-34.

Truong AB, Kretz M, Ridky TW, Kimmel R, Khavari PA. (2006) p63 regulates proliferation and differentiation of developmentally mature keratinocytes.  Genes Dev. Nov 15;20(22):3185-97.

Ridky T.W. and Khavari P.A. (2004) Pathways sufficient to induce epidermal carcinogenesis.
Cell Cycle. May;3(5):621-4.

Chang, H.Y., Ridky, T.W., Kimball, A.B., Hughes, E., and Oro, A.E.  (2003) Eruptive xanthomas associated with olanzapine use Arch. Derm. 139, 1045-1048.

Hindmarsh, P., Ridky, T.W., Reeves, R., Andrake, M., Skalka, A., and Leis, J.  (1999) HMG protein family members stimulate HIV-1 and ASV concerted DNA Integration in vitro.  J. Virol. 73, 2994-3003.

Ridky, T. W., Kikonyogo, A., Leis, J., Gulnik, S., Copeland, T., Erickson, J., Wlodawer, A., Kurinov, I., Harrison, R., and Weber, I. (1998) Drug Resistant HIV-1 Proteases Identify Amino Acid Residues Important for Substrate Specificity and Catalytic Rate. Biochemistry 37, 13835-13845.

Xiang, Y., Ridky, T.W., Krishna, N., and Leis, J. (1997) Altered Rous sarcoma virus Gag processing and its effects on particle formation. J. Virol. 71, 2083-2091.

Ridky, T.W., Bizub-Bender, D., Cameron, C.E., Weber, I., Wlodawer, A., Copeland, T., Skalka, A., and Leis, J. (1996)  Programming the Rous Sarcoma Virus Protease to Cleave New Subtrate Sequences. J. Biol. Chem. 271, 10538 - 10544.

Ridky, T.W., Cameron, C. E., Cameron, J., Leis, J., Weber, I., Wlodawer, A., and Copeland, T.  (1996)  HIV-1 Protease Specificity is Limited by Interactions Between Substrate Amino Acid Side Chains in Adjacent Enzyme Subsites. J. Biol. Chem. 271, 4709-4717.

Ridky, T.W., and Leis, J. (1995) Development of Resistance to HIV-1 Protease Inhibitors. J. Biol. Chem. 270, 29621-29623.