Listed below are many of the labs affiliated with the U Penn RNA Group. We come from all schools at U Penn as well as other academic institutions around Philadelphia. Many of us are not necessarily "RNA labs", but rather have specific individuals/projects that are focused on RNA function, RNA-based gene regulation or RNA binding proteins. We welcome you to get to know us and join us!


Alphabetical by PI

Montserrat C. Anguera, PhD
Department of Animal Biology, U Penn School of Veterinary Medicine

We investigate the function and mechanism of long noncoding RNAs during early human development. We are particularly interested in transcripts that regulate X-Chromosome Inactivation, and use pluripotent stem cells as a model system.
Lab website

Yoseph Barash, PhD
Department of Genetics, U Penn Perelman School of Medicine

The BioCiphers lab develops machine learning algorithms that combine genomics and genetic data to study RNA biogenesis and post-transcriptional regulation. A main focus of the lab is developing predictive models for alternative splicing and applying them for studies of human disease and phenotypic diversity.
Lab website

Nancy M. Bonini, PhD
Department of Biology, U Penn School of Arts and Sciences

Our laboratory is defining toxicity pathways of RNA binding proteins and small RNA pathways that impact human neurodegenerative disease and brain aging. We launch from Drosophila as an in vivo system, and use genetics, cell biology, molecular biology, genomics and other molecular and cellular techniques to gain insight into key pathways of critical important to the brain normally and in disease.
Lab website

Tara L. Davis, PhD
Department of Biochemistry and Molecular Biology, Drexel University College of Medicine

The Davis Lab uses a variety of biochemical, biophysical, and cell biology techniques to study the regulatory roles of accessory proteins of the human spliceosome. We focus on the nuclear cyclophilins and the protein:protein interactions they participate in during the various stages of splicing, and what the consequences of these interactions are on spliceosomal assembly,catalysis, and splice choice.
Lab website

Russ Carstens, MD
Department of Medicine, U Penn Perelman School of Medicine

Lab website

Sara Cherry, PhD
Department of Microbiology, U Penn Perelman School of Medicine

Lab website

Beverly Davidson, PhD
Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia

Lab website

Gideon Dreyfuss, PhD
Department of Biochemistry and Biophysics, U Penn Perelman School of Medicine

Lab website

James Eberwine, PhD
Departments of Pharmacology and Psychiatry, U Penn Perelman School of Medicine

My lab utilizes the techniques of genomics, biochemistry, chemistry, molecular biology, imaging and computational biology to study quantitative aspects of RNA function in live single cells. We have developed many of the molecular techniques that permit single cell genomics to be assessed.
Lab website

Brian D. Gregory, PhD
Department of Biology, U Penn School of Arts and Sciences

We combine classic biochemical approaches with high-throughput sequencing to study RNA secondary structure and RNA-protein interactions genome-wide in eukaryotic organisms.
Lab website

Qihong Huang, MD, PhD
Department of Tumor Microenvironment and Metastasis, The Wistar Institute

Our laboratory utilizes functional genomics approaches to understand the functions of microRNAs and long non-coding RNAs in tumor metastasis and explore the molecular mechanisms of non-coding RNAs in this process.
Lab website

Susan M. Janicki, PhD
Molecular and Cellular Oncogenesis Program, The Wistar Institute

My lab uses single-cell live-cell imaging to study how chromatin and gene expression are coordinately regulated. We are particularly interested in mechanisms, which regulate RNA-mediated gene silencing in mammals.

Stephen A. Liebhaber, MD
Department of Genetics, U Penn Perelman School of Medicine

Our laboratory is exploring the spectrum of post-transcriptional controls mediated by two families of RNA binding proteins; polyC-binding proteins (aCPs, hnRNP Es) and the polyA binding proteins (PABPs). These proteins play critical roles in both nuclear and cytoplasmic controls over RNA processing and cytoplasmic mRNA stability. Our approaches integrate in vitro biochemical studies with cell culture and engineered mouse models in order to explore mechanisms and physiologic impacts of these proteins on mammalian gene expression.
Lab website

Kristen W. Lynch, PhD
Departments of Biochemistry and Biophysics and Genetics, U Penn Perelman School of Medicine

We combine biochemistry, genomics and molecular biology to study mechanism and consequences of regulated alternative splicing. Our particular emphasis is signal-regulated splicing in human T cells.
Lab website

Zissimos Mourelatos, MD
Department of Pathology, U Penn Perelman School of Medicine

Lab website

Kazuko Nishikura, PhD
Department of Gene Expression and Regulation, The Wistar Institute

ADAR (adenosine deaminase acting on RNA) converts adenosine residues into inosine (A-to-I RNA editing). Our research efforts are aimed to better understand the functions of ADAR and the cellular processes regulated by A-to-I RNA editing and to identify possible human diseases caused by malfunction of these processes.
Lab website

Arjun Raj, PhD
Department of Bioengineering, U Penn School of Engineering and Applied Science

Lab website

James Shorter, PhD
Department of Biochemistry and Biophysics, U Penn Perelman School of Medicine

Lab website

Andre Thomas-Tikhonenko, PhD
Division of Cancer Pathobiology, Children's Hospital of Philadelphia

Lab website

Matthew Weitzman, PhD
Perelman Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia

Lab website

Jeremy E. Wilusz, PhD
Department of Biochemistry and Biophysics, U Penn Perelman School of Medicine

We are interested in the mechanisms by which noncoding RNAs are generated, regulated, and function.
Lab website