Perelman School of Medicine at the University of Pennsylvania

Section for Biomedical Image Analysis (SBIA)

Multi-modal brain MRI pattern analysis of childhood-onset ADHD in never-treated adults


Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent and potentially disabling neurodevelopmental disorder in children and adolescents. The validity of the diagnosis of ADHD in adulthood has often been the subject of controversy. In the ADHD study, in collaboration with Dr. Geraldo F. Bussato and Dr. Marcus V. Zanetti from the University of Sao Paulo, Brazil, we investigated whether neuroimaging measures sufficiently discriminate patients fulfilling diagnostic criteria for childhood-onset ADHD in adulthood from healthy controls (HC) on an individual basis, by applying machine learning-based pattern classification methods to multi-modal MRI data obtained in a sample of never-treated ADHD patients.