Stem Cell Function Stem%20Cells.htmlshapeimage_1_link_0
 
Rotation Projects for 2008-2009 Stem Cell Biology Projects: Students will explore the intimate cooperation between stem cells within a niche. Using genetic and genomic techniques, you will not only identify factors that govern the balance between stem cell self-renewal and differentiation, but also uncover concepts that are likely to apply generally to other stem cell – niche systems. With the completion of the Drosophila genome sequence, we have used microarray and other technology to derive a list of genes enriched in stem cells and the stem cell niche. Students can participate in functional studies of any of several novel genes that each effect the behavior of stem cells. Through our association with the Institute for Regenerative Medicine, collaborative opportunities exist for translational work, where students can explore whether our discoveries in Drosophila apply to mammalian spermatogenesis as well as other stem cell systems investigated here at Penn. Cell Biology of Developmental Patterning Projects: Students will participate in the investigation of how developmentally important signaling pathways control the cell biological responses of their target cells. This involves examining the cytoskeletal changes that occur during cell differentiation in real-time, using live embryo imaging, as well as by other high resolution imaging and microscopy techniques. These approaches are complemented by molecular manipulation of target proteins of these signaling pathways, such as small GTPases, adhesion and polarity proteins, and cytoskeletal components. Congrats, Steve! 2008 Recipient of the Dean’s Award for Excellence in Biomedical Graduate Student Training DiNardo Lab Built Tough with an Exoskeleton
Lab Personnel Steve DiNardo Principal Investigator Judy Leatherman Post-doctoral Fellow Stacie Dilks PhD Student Bob Simone PhD Student Tishina Okegbe PhD Student Sarah Freilich Research assistant Seth Donoughe Research assistant Stephen DiNardo Cell & Developmental Biology Institute for Regenerative Medicine 1220 BRB 2-3 421 Curie Blvd Philadelphia, PA 19104 215-898-4553 Email Steve Last Updated: 09/2008 mailto:sdinardo@mail.med.upenn.edu?subject=from%20the%20websiteshapeimage_5_link_0
 
 
Lab Publications (searches the National Library of Medicine's PubMed database) LAB PROTOCOLS http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Search&db=pubmed&term=%22DiNardo%20S%22%5Bau%5DProtocols.htmlshapeimage_7_link_0shapeimage_7_link_1
 
Linkout - Drosophila Sites FlyBase - Drosophila genome database BDGP - Berkeley Drosophila Genome Project Homophila - Human Disease to Drosophila Gene The Interactive Fly 2009 Drosophila Conference Linkout - U of PA Sites Cell and Developmental Biology Steve’s CAMB Page Steve’s CDB Page Institute for Regenerative Medicine http://www.flybase.orghttp://www.fruitfly.org/http://superfly.ucsd.edu/homophila/http://www.sdbonline.org/fly/aimain/1aahome.htmhttp://www.drosophila-conf.org/2009/http://www.med.upenn.edu/cellbio/http://www.med.upenn.edu/camb/faculty/db/dinardo.htmlhttp://www.med.upenn.edu/apps/faculty/index.php/g305/p17648http://www.irm.upenn.edu/shapeimage_9_link_0shapeimage_9_link_1shapeimage_9_link_2shapeimage_9_link_3shapeimage_9_link_4shapeimage_9_link_5shapeimage_9_link_6shapeimage_9_link_7shapeimage_9_link_8
Cell Biology of Developmental Patterning Patterning.htmlPatterning.htmlshapeimage_10_link_0shapeimage_10_link_1