Recent Publications

  1. EBF2 determines and maintains brown adipocyte identity.
    Rajakumari S, Wu J, Ishibashi J, Hee-Woong L, Won KJ, Reed RR, Seale P. (2013). Cell Metab. (in press)

Additional Publications (pubmed)

  1. An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation.
    Ishibashi J, Firtina Z, Rajakumari S, Wood KH, Conroe HM, Steger DJ, Seale P. (2012). Mol Cell Biol. 32(12):2289-99.
    PubMed: 22473998; PubMedCentral: PMC3372274; DOI: 10.1128/MCB.06529-11
  2. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.
    Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM. (2011). J Clin Invest. 121(1):96-105
    PubMed: 21123942; DOI: 10.1172/JCI44271
  3. Transcriptional control of brown adipocyte development and thermogenesis.
    Seale P. (2010). Int J Obes (Lond). 34 Suppl 1:S17-22.
    PubMed: 20935660; DOI: 10.1038/ijo.2010.178
  4. Beige can be slimming.
    Ishibashi J, Seale P. (2010). Science. 328(5982):1113-4.
    PubMed: 20448151; DOI: 10.1126/science.1190816
  5. Transcriptional control of brown fat development.
    Kajimura S, Seale P, Spiegelman BM. (2010). Cell Metab. 11(4):257-62. Review.
    PubMed: 20374957; DOI: 10.1016/j.cmet.2010.03.005
  6. Transcriptional control of preadipocyte determination by Zfp423.
    Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM. (2010). Nature. 464(7288):619-23.
    PubMed: 20200519; DOI: 10.1038/nature08816
  7. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.
    Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM. (2009). Nature. 460(7259):1154-8.
    PubMed: 19641492; DOI: 10.1038/nature08262
  8. Brown fat in humans: turning up the heat on obesity.
    Seale P, Lazar MA. (2009). Diabetes. 58:1482-4. Preview.
    PubMed: 19564460; DOI: 10.2337/db09-0622
  9. Transcriptional control of brown adipocyte development and physiological function--of mice and men.
    Seale P, Kajimura S, Spiegelman, BM. (2009). Genes Dev. 23:788-97. Review.
    PubMed: 19339685; DOI: 10.1101/gad.1779209
  10. PRDM16 Controls a Brown Fat/Skeletal Muscle Switch.
    Seale P, Bjork B, Yang W, Kajimura S, Kuang S, Scime A, Devarakonda S, Chin S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. (2008). Nature, 454, 961-967.
    PubMed: 18719582; DOI: 10.1038/nature07182
  11. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
    Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM. (2008). Genes Dev. 22, 1397-409.
    PubMed: 18483224; DOI: 10.1101/gad.1666108
  12. Transcriptional control of brown fat determination by PRDM16.
    Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. (2007). Cell Metab. 6, 38-54.
    PubMed: 17618855