Recent Publications

  1. EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex.
    Shapira SN, Lim HW, Rajakumari S, Sakers AP, Ishibashi J, Harms MJ, Won KJ, Seale P. (2017). Genes Dev. 31(7):660-673.
    PubMed: 28428261; DOI: 10.1101/gad.294405.116
  2. PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing.
    Kissig M, Ishibashi J, Harms MJ, Lim HW, Stine RR, Won KJ, Seale P. (2017). EMBO J. 36(11):1528-1542.
    PubMed: 28408438; DOI: 10.15252/embj.201695588

Additional Publications (pubmed)

  1. Control of brown and beige fat development.
    Wang W, Seale P. (2016). Nat Rev Mol Cell Biol. 17(11):691-702.
    PubMed: 27552974; DOI: 10.1038/nrm.2016.96
  2. SnapShot: Brown and Beige Adipose Thermogenesis.
    Kissig M, Shapira SN, Seale P. (2016). Cell. 166(1):258-258.e1.
    PubMed: 27368105; PubMedCentral: PMC5478388; DOI: 10.1016/j.cell.2016.06.038
  3. EBF2 promotes the recruitment of beige adipocytes in white adipose tissue.
    Stine RR, Shapira SN, Lim HW, Ishibashi J, Harms M, Won KJ, Seale P. (2015). Mol Metab. 5(1):57-65.
    PubMed: 26844207; PubMedCentral: PMC4703852; DOI: 10.1016/j.molmet.2015.11.001
  4. Brown and Beige Fat: Physiological Roles beyond Heat Generation.
    Kajimura S, Spiegelman BM, Seale P. (2015). Cell Metab. 22(4):546-59.
    PubMed: 26445512; PubMedCentral: PMC4613812; DOI: 10.1016/j.cmet.2015.09.007
  5. Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation.
    Seale P. (2015). Diabetes. 64(7):2369-75.
    PubMed: 26050669; PubMedCentral: PMC4477361; DOI: 10.2337/db15-0203
  6. PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program.
    Harms MJ, Lim HW, Ho Y, Shapira SN, Ishibashi J, Rajakumari S, Steger DJ, Lazar MA, Won KJ, Seale P. (2015). Genes Dev. 29(3):298-307.
    PubMed: 25644604; PubMedCentral: PMC4318146; DOI: 10.1101/gad.252734.114
  7. Functions of Prdm16 in thermogenic fat cells..
    Ishibashi J, Seale P. (2015). Temperature. 2(1):65-72.
    PubMed: 27227007; PubMedCentral: PMC4843880; DOI: 10.4161/23328940.2014.974444
  8. Ebf2 is a selective marker of brown and beige adipogenic precursor cells.
    Wang W, Kissig M, Rajakumari S, Huang L, Lim HW, Won KJ, Seale P. (2014). PNAS. 111(40):14466-71.
    PubMed: 25197048; PubMedCentral: PMC4209986; DOI: 10.1073/pnas.1412685111
  9. Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.
    Harms MJ, Ishibashi J, Wang W, Lim HW, Goyama S, Sato T, Kurokawa M, Won KJ, Seale P. (2014). Cell Metab. 19(4):593-604.
    PubMed: 24703692; PubMedCentral: PMC4012340; DOI: 10.1016/j.cmet.2014.03.007
  10. Brown and beige fat: development, function and therapeutic potential.
    Harms M, Seale P. (2013). Nat Med. 19(10):1252-63.
    PubMed: 24100998; DOI: 10.1038/nm.3361
  11. Brown adipose tissue biology and therapeutic potential..
    Seale P. (2013). Front Endocrinol (Lausanne). 4:14.
    PubMed: 23513074 ; PubMedCentral: PMC3601303; DOI: 10.3389/fendo.2013.00014
  12. EBF2 determines and maintains brown adipocyte identity.
    Rajakumari S, Wu J, Ishibashi J, Hee-Woong L, Won KJ, Reed RR, Seale P. (2013). Cell Metab. 17(4):562-74.
    PubMed: 23499423; PubMedCentral: PMC3622114; DOI: 10.1016/j.cmet.2013.01.015
  13. An Evi1-C/EBPβ complex controls peroxisome proliferator-activated receptor γ2 gene expression to initiate white fat cell differentiation.
    Ishibashi J, Firtina Z, Rajakumari S, Wood KH, Conroe HM, Steger DJ, Seale P. (2012). Mol Cell Biol. 32(12):2289-99.
    PubMed: 22473998; PubMedCentral: PMC3372274; DOI: 10.1128/MCB.06529-11
  14. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice.
    Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM. (2011). J Clin Invest. 121(1):96-105
    PubMed: 21123942; DOI: 10.1172/JCI44271
  15. Transcriptional control of brown adipocyte development and thermogenesis.
    Seale P. (2010). Int J Obes (Lond). 34 Suppl 1:S17-22.
    PubMed: 20935660; DOI: 10.1038/ijo.2010.178
  16. Beige can be slimming.
    Ishibashi J, Seale P. (2010). Science. 328(5982):1113-4.
    PubMed: 20448151; DOI: 10.1126/science.1190816
  17. Transcriptional control of brown fat development.
    Kajimura S, Seale P, Spiegelman BM. (2010). Cell Metab. 11(4):257-62. Review.
    PubMed: 20374957; DOI: 10.1016/j.cmet.2010.03.005
  18. Transcriptional control of preadipocyte determination by Zfp423.
    Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM. (2010). Nature. 464(7288):619-23.
    PubMed: 20200519; DOI: 10.1038/nature08816
  19. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.
    Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM. (2009). Nature. 460(7259):1154-8.
    PubMed: 19641492; DOI: 10.1038/nature08262
  20. Brown fat in humans: turning up the heat on obesity.
    Seale P, Lazar MA. (2009). Diabetes. 58:1482-4. Preview.
    PubMed: 19564460; DOI: 10.2337/db09-0622
  21. Transcriptional control of brown adipocyte development and physiological function--of mice and men.
    Seale P, Kajimura S, Spiegelman, BM. (2009). Genes Dev. 23:788-97. Review.
    PubMed: 19339685; DOI: 10.1101/gad.1779209
  22. PRDM16 Controls a Brown Fat/Skeletal Muscle Switch.
    Seale P, Bjork B, Yang W, Kajimura S, Kuang S, Scime A, Devarakonda S, Chin S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. (2008). Nature, 454, 961-967.
    PubMed: 18719582; DOI: 10.1038/nature07182
  23. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex.
    Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM. (2008). Genes Dev. 22, 1397-409.
    PubMed: 18483224; DOI: 10.1101/gad.1666108
  24. Transcriptional control of brown fat determination by PRDM16.
    Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. (2007). Cell Metab. 6, 38-54.
    PubMed: 17618855