Publications
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Circadian regulation of lung repair and regeneration.
Naik A, Forrest KM, Paul O, Issah Y, Valekunja UK, Tang SY, Reddy AB, Hennessy EJ, Brooks TG, Chaudhry F, Babu A, Morley M, Zepp JA, Grant GR, FitzGerald GA, Sehgal A, Worthen GS, Frank DB, Morrisey EE, Sengupta S. JCI insight. 2024 Mar 8;9(5) -
Cell state dependent effects of Bmal1 on melanoma immunity and tumorigenicity.
Zhang X, Pant SM, Ritch CC, Tang HY, Shao H, Dweep H, Gong YY, Brooks R, Brafford P, Wolpaw AJ, Lee Y, Weeraratna A, Sehgal A, Herlyn M, Kossenkov A, Speicher D, Sorger PK, Santagata S, Dang CV. Nature communications. 2024 Jan 20;15(1):633 -
Age-regulated cycling metabolites are relevant for behavior.
Schwarz JE, Sengupta A, Guevara C, Barber AF, Hsu CT, Zhang SL, Weljie A, Sehgal A. Aging cell. 2024 Jan 11;:e14082 -
Hypermetabolic state is associated with circadian rhythm disruption in mouse and human cancer cells.
Iascone DM, Zhang X, Bafford P, Mesaros C, Sela Y, Hofbauer S, Zhang SL, Cook K, Pivarshev P, Stanger BZ, Anderson S, Dang CV, Sehgal A. bioRxiv : the preprint server for biology. 2023 Nov 13 -
Altered Metabolism During the Dark Period in Drosophila Short Sleep Mutants.
Malik DM, Sengupta A, Sehgal A, Weljie AM. bioRxiv : the preprint server for biology. 2023 Nov 2 -
Glucose Challenge Uncovers Temporal Fungibility of Metabolic Homeostasis Throughout the Day.
Malik DM, Rhoades SD, Zhang SL, Sengupta A, Barber A, Haynes P, Arnadottir ES, Pack A, Kibbey RG, Sehgal A, Weljie AM. bioRxiv : the preprint server for biology. 2023 Nov 2 -
Circadian regulation of lung repair and regeneration.
Naik A, Forrest KM, Paul O, Issah Y, Valekunja UK, Tang SY, Reddy AB, Hennessy EJ, Brooks TG, Chaudhry F, Babu A, Morley M, Zepp JA, Grant GR, FitzGerald GA, Sehgal A, Worthen GS, Frank DB, Morrisey EE, Sengupta S. JCI insight. 2023 Aug 22;8(16) -
Modulation of sleep by trafficking of lipids through the Drosophila blood-brain barrier.
Li F, Artiushin G, Sehgal A. eLife. 2023 May 4;12 -
Variant-to-gene, gene-to-trait: finding new sleep genes through GWAS.
Noya SB, Sehgal A. Trends in genetics : TIG. 2023 May;39(5):338-339 Epub 2023 Feb 28 -
Chronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress.
Bedont JL, Kolesnik A, Pivarshev P, Malik D, Hsu CT, Weljie A, Sehgal A. Current biology : CB. 2023 Apr 24;33(8):1613-1623.e5 Epub 2023 Mar 24 -
Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms.
Schwarz JE, Mrčela A, Lahens NF, Li Y, Hsu CT, Grant G, Skarke C, Zhang SL, Sehgal A. bioRxiv : the preprint server for biology. 2023 Apr 20 -
Ecdysone acts through cortex glia to regulate sleep in Drosophila.
Li Y, Haynes P, Zhang SL, Yue Z, Sehgal A. eLife. 2023 Jan 31;12 -
The microbiome stabilizes circadian rhythms in the gut.
Zhang Y, Li Y, Barber AF, Noya SB, Williams JA, Li F, Daniel SG, Bittinger K, Fang J, Sehgal A. Proceedings of the National Academy of Sciences of the United States of America. 2023 Jan 31;120(5):e2217532120 Epub 2023 Jan 23 -
The Kinetics and (Dys)kinetics of Cancer Chronotherapy.
Field JM, Sehgal A. Cancer research. 2022 Jul 5;82(13):2357-2360 -
Consolidation of Sleep-Dependent Appetitive Memory Is Mediated by a Sweet-Sensing Circuit.
Chouhan NS, Sehgal A. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022 May 4;42(18):3856-3867 Epub 2022 Mar 31 -
Demystifying the Neuroprotective Role of Neuropeptides in Parkinson's Disease: A Newfangled and Eloquent Therapeutic Perspective.
Behl T, Madaan P, Sehgal A, Singh S, Makeen HA, Albratty M, Alhazmi HA, Meraya AM, Bungau S. International journal of molecular sciences. 2022 Apr 20;23(9) -
Investigation of the Molecular Role of Brain-Derived Neurotrophic Factor in Alzheimer's Disease.
Girotra P, Behl T, Sehgal A, Singh S, Bungau S. Journal of molecular neuroscience : MN. 2022 Feb;72(2):173-186 Epub 2021 Aug 23 -
Circadian Rhythms, Disease and Chronotherapy.
Lee Y, Field JM, Sehgal A. Journal of biological rhythms. 2021 Dec;36(6):503-531 Epub 2021 Sep 22 -
Hugin(+) neurons provide a link between sleep homeostat and circadian clock neurons.
Schwarz JE, King AN, Hsu CT, Barber AF, Sehgal A. Proceedings of the National Academy of Sciences of the United States of America. 2021 Nov 23;118(47) -
Elucidating the Possible Role of FoxO in Depression.
Rana T, Behl T, Sehgal A, Mehta V, Singh S, Sharma N, Bungau S. Neurochemical research. 2021 Nov;46(11):2761-2775 Epub 2021 Jun 1 -
Unfolding the Role of BDNF as a Biomarker for Treatment of Depression.
Rana T, Behl T, Sehgal A, Srivastava P, Bungau S. Journal of molecular neuroscience : MN. 2021 Oct;71(10):2008-2021 Epub 2020 Nov 23 -
Short and long sleeping mutants reveal links between sleep and macroautophagy.
Bedont JL, Toda H, Shi M, Park CH, Quake C, Stein C, Kolesnik A, Sehgal A. eLife. 2021 Jun 4;10 -
Manipulations of the olfactory circuit highlight the role of sensory stimulation in regulating sleep amount.
Hsu CT, Choi JTY, Sehgal A. Sleep. 2021 May 14;44(5) -
Drosophila clock cells use multiple mechanisms to transmit time-of-day signals in the brain.
Barber AF, Fong SY, Kolesnik A, Fetchko M, Sehgal A. Proceedings of the National Academy of Sciences of the United States of America. 2021 Mar 9;118(10) -
Loss of circadian protection against influenza infection in adult mice exposed to hyperoxia as neonates.
Issah Y, Naik A, Tang SY, Forrest K, Brooks TG, Lahens N, Theken KN, Mermigos M, Sehgal A, Worthen GS, FitzGerald GA, Sengupta S. eLife. 2021 Mar 2;10 -
Time-of-day specificity of anticancer drugs may be mediated by circadian regulation of the cell cycle.
Lee Y, Fong SY, Shon J, Zhang SL, Brooks R, Lahens NF, Chen D, Dang CV, Field JM, Sehgal A. Science advances. 2021 Feb;7(7) Epub 2021 Feb 12 -
The 2020 Pittendrigh/Aschoff Lecture: My Circadian Journey.
Sehgal A. Journal of biological rhythms. 2021 Feb;36(1):84-96 Epub 2021 Jan 11 -
A circadian clock regulates efflux by the blood-brain barrier in mice and human cells.
Zhang SL, Lahens NF, Yue Z, Arnold DM, Pakstis PP, Schwarz JE, Sehgal A. Nature communications. 2021 Jan 27;12(1):617 -
Monitoring Electrical Activity in Drosophila Circadian Output Neurons.
Barber AF, Sehgal A. Methods in molecular biology (Clifton, N.J.). 2021;2130:221-232 -
Availability of food determines the need for sleep in memory consolidation.
Chouhan NS, Griffith LC, Haynes P, Sehgal A. Nature. 2021 Jan;589(7843):582-585 Epub 2020 Dec 2 -
Glial Metabolic Rewiring Promotes Axon Regeneration and Functional Recovery in the Central Nervous System.
Li F, Sami A, Noristani HN, Slattery K, Qiu J, Groves T, Wang S, Veerasammy K, Chen YX, Morales J, Haynes P, Sehgal A, He Y, Li S, Song Y. Cell metabolism. 2020 Nov 3;32(5):767-785.e7 Epub 2020 Sep 16 -
The Lineage Before Time: Circadian and Nonclassical Clock Influences on Development.
Bedont JL, Iascone DM, Sehgal A. Annual review of cell and developmental biology. 2020 Oct 6;36:469-509 -
AANAT1 functions in astrocytes to regulate sleep homeostasis.
Davla S, Artiushin G, Li Y, Chitsaz D, Li S, Sehgal A, van Meyel DJ. eLife. 2020 Sep 21;9 -
The Glial Perspective on Sleep and Circadian Rhythms.
Artiushin G, Sehgal A. Annual review of neuroscience. 2020 Jul 8;43:119-140 Epub 2020 Feb 19 -
Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster.
Jacobs JA, Sehgal A. Cell reports. 2020 Jun 2;31(9):107710 -
Circadian and Sleep Metabolomics Across Species.
Malik DM, Paschos GK, Sehgal A, Weljie AM. Journal of molecular biology. 2020 May 29;432(12):3578-3610 Epub 2020 May 3 -
RNA Splicing Factor Mutations That Cause Retinitis Pigmentosa Result in Circadian Dysregulation.
Shakhmantsir I, Dooley SJ, Kishore S, Chen D, Pierce E, Bennett J, Sehgal A. Journal of biological rhythms. 2020 Feb;35(1):72-83 Epub 2019 Nov 15 -
Molecular and circuit mechanisms mediating circadian clock output in the Drosophila brain.
King AN, Sehgal A. The European journal of neuroscience. 2020 Jan;51(1):268-281 Epub 2018 Aug 16 -
Splicing the Clock to Maintain and Entrain Circadian Rhythms.
Shakhmantsir I, Sehgal A. Journal of biological rhythms. 2019 Dec;34(6):584-595 Epub 2019 Aug 7 -
Misregulation of Drosophila Myc Disrupts Circadian Behavior and Metabolism.
Hsieh AL, Zheng X, Yue Z, Stine ZE, Mancuso A, Rhoades SD, Brooks R, Weljie AM, Eisenman RN, Sehgal A, Dang CV. Cell reports. 2019 Nov 12;29(7):1778-1788.e4 -
The NRON complex controls circadian clock function through regulated PER and CRY nuclear translocation.
Lee Y, Shen Y, Francey LJ, Ramanathan C, Sehgal A, Liu AC, Hogenesch JB. Scientific reports. 2019 Aug 15;9(1):11883 -
Regulation of the Blood-Brain Barrier by Circadian Rhythms and Sleep.
Cuddapah VA, Zhang SL, Sehgal A. Trends in neurosciences. 2019 Jul;42(7):500-510 -
Altered ocular parameters from circadian clock gene disruptions.
Stone RA, McGlinn AM, Chakraborty R, Lee DC, Yang V, Elmasri A, Landis E, Shaffer J, Iuvone PM, Zheng X, Sehgal A, Pardue MT. PloS one. 2019;14(6):e0217111 Epub 2019 Jun 18 -
G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment.
Lee Y, Lahens NF, Zhang S, Bedont J, Field JM, Sehgal A. PLoS biology. 2019 Apr;17(4):e3000228 Epub 2019 Apr 30 -
A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila.
Toda H, Williams JA, Gulledge M, Sehgal A. Science (New York, N.Y.). 2019 Feb 1;363(6426):509-515 -
Spliceosome factors target timeless (tim) mRNA to control clock protein accumulation and circadian behavior in Drosophila.
Shakhmantsir I, Nayak S, Grant GR, Sehgal A. eLife. 2018 Dec 5;7 -
Endocytosis at the Drosophila blood-brain barrier as a function for sleep.
Artiushin G, Zhang SL, Tricoire H, Sehgal A. eLife. 2018 Nov 26;7 -
Circadian and Sleep Circuits Ring Together.
Hsu CT, Sehgal A. Neuron. 2018 Nov 7;100(3):514-516 -
Asymmetric vasopressin signaling spatially organizes the master circadian clock.
Bedont JL, Rohr KE, Bathini A, Hattar S, Blackshaw S, Sehgal A, Evans JA. The Journal of comparative neurology. 2018 Sep 1;526(13):2048-2067 Epub 2018 Aug 22 -
Cold Temperatures Fire up Circadian Neurons.
Barber AF, Sehgal A. Cell metabolism. 2018 May 1;27(5):951-953 -
Wolbachia affects sleep behavior in Drosophila melanogaster.
Bi J, Sehgal A, Williams JA, Wang YF. Journal of insect physiology. 2018 May-Jun;107:81-88 Epub 2018 Feb 27 -
Circadian- and Light-driven Metabolic Rhythms in Drosophila melanogaster.
Rhoades SD, Nayak K, Zhang SL, Sehgal A, Weljie AM. Journal of biological rhythms. 2018 Apr;33(2):126-136 Epub 2018 Jan 21 -
A Conserved Circadian Function for the Neurofibromatosis 1 Gene.
Bai L, Lee Y, Hsu CT, Williams JA, Cavanaugh D, Zheng X, Stein C, Haynes P, Wang H, Gutmann DH, Sehgal A. Cell reports. 2018 Mar 27;22(13):3416-3426 -
A Circadian Clock in the Blood-Brain Barrier Regulates Xenobiotic Efflux.
Zhang SL, Yue Z, Arnold DM, Artiushin G, Sehgal A. Cell. 2018 Mar 22;173(1):130-139.e10 Epub 2018 Mar 8 -
Genetic Mechanisms Underlying Sleep.
Toda H, Shi M, Williams JA, Sehgal A. Cold Spring Harbor symposia on quantitative biology. 2018;83:57-61 Epub 2019 Apr 1 -
Physiology Flies with Time.
Sehgal A. Cell. 2017 Nov 30;171(6):1232-1235 -
Guidelines for Genome-Scale Analysis of Biological Rhythms.
Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptáček LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB. Journal of biological rhythms. 2017 Oct;32(5):380-393 Epub 2017 Nov 3 -
Molecular Mechanisms of Sleep Homeostasis in Flies and Mammals.
Allada R, Cirelli C, Sehgal A. Cold Spring Harbor perspectives in biology. 2017 Aug 1;9(8) -
Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model.
Monyak RE, Emerson D, Schoenfeld BP, Zheng X, Chambers DB, Rosenfelt C, Langer S, Hinchey P, Choi CH, McDonald TV, Bolduc FV, Sehgal A, McBride SMJ, Jongens TA. Molecular psychiatry. 2017 Aug;22(8):1140-1148 Epub 2016 Apr 19 -
A Peptidergic Circuit Links the Circadian Clock to Locomotor Activity.
King AN, Barber AF, Smith AE, Dreyer AP, Sitaraman D, Nitabach MN, Cavanaugh DJ, Sehgal A. Current biology : CB. 2017 Jul 10;27(13):1915-1927.e5 Epub 2017 Jun 29 -
The Drosophila circuitry of sleep-wake regulation.
Artiushin G, Sehgal A. Current opinion in neurobiology. 2017 Jun;44:243-250 Epub 2017 Mar 30 -
Circadian Rhythms and Sleep in Drosophila melanogaster.
Dubowy C, Sehgal A. Genetics. 2017 Apr;205(4):1373-1397 -
Human and rat gut microbiome composition is maintained following sleep restriction.
Zhang SL, Bai L, Goel N, Bailey A, Jang CJ, Bushman FD, Meerlo P, Dinges DF, Sehgal A. Proceedings of the National Academy of Sciences of the United States of America. 2017 Feb 21;114(8):E1564-E1571 Epub 2017 Feb 8 -
Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells.
Barber AF, Erion R, Holmes TC, Sehgal A. Genes & development. 2016 Dec 1;30(23):2596-2606 Epub 2016 Dec 15 -
Changes in Female Drosophila Sleep following Mating Are Mediated by SPSN-SAG Neurons.
Garbe DS, Vigderman AS, Moscato E, Dove AE, Vecsey CG, Kayser MS, Sehgal A. Journal of biological rhythms. 2016 Dec;31(6):551-567 Epub 2016 Sep 22 -
Genetic Dissociation of Daily Sleep and Sleep Following Thermogenetic Sleep Deprivation in Drosophila.
Dubowy C, Moravcevic K, Yue Z, Wan JY, Van Dongen HP, Sehgal A. Sleep. 2016 May 1;39(5):1083-95 -
Neural clocks and Neuropeptide F/Y regulate circadian gene expression in a peripheral metabolic tissue.
Erion R, King AN, Wu G, Hogenesch JB, Sehgal A. eLife. 2016 Apr 14;5 -
Control of Metabolism by Central and Peripheral Clocks in Drosophila.
Sassone-Corsi P, Christen Y, Sehgal A. . 2016 -
Circadian Rhythms, Sleep, and Disorders of Aging.
Mattis J, Sehgal A. Trends in endocrinology and metabolism: TEM. 2016 Apr;27(4):192-203 Epub 2016 Mar 3 -
The Drosophila Circadian Clock Gates Sleep through Time-of-Day Dependent Modulation of Sleep-Promoting Neurons.
Cavanaugh DJ, Vigderman AS, Dean T, Garbe DS, Sehgal A. Sleep. 2016 Feb 1;39(2):345-56 -
Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila.
Katewa SD, Akagi K, Bose N, Rakshit K, Camarella T, Zheng X, Hall D, Davis S, Nelson CS, Brem RB, Ramanathan A, Sehgal A, Giebultowicz JM, Kapahi P. Cell metabolism. 2016 Jan 12;23(1):143-54 Epub 2015 Nov 25 -
Ribosome profiling reveals an important role for translational control in circadian gene expression.
Jang C, Lahens NF, Hogenesch JB, Sehgal A. Genome research. 2015 Dec;25(12):1836-47 Epub 2015 Sep 3 -
Drosophila Nipped-B Mutants Model Cornelia de Lange Syndrome in Growth and Behavior.
Wu Y, Gause M, Xu D, Misulovin Z, Schaaf CA, Mosarla RC, Mannino E, Shannon M, Jones E, Shi M, Chen WF, Katz OL, Sehgal A, Jongens TA, Krantz ID, Dorsett D. PLoS genetics. 2015 Nov;11(11):e1005655 Epub 2015 Nov 6 -
Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep.
Bai L, Sehgal A. PLoS genetics. 2015 Nov;11(11):e1005611 Epub 2015 Nov 4 -
KPNB1 mediates PER/CRY nuclear translocation and circadian clock function.
Lee Y, Jang AR, Francey LJ, Sehgal A, Hogenesch JB. eLife. 2015 Aug 29;4 -
Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis.
Maguire SE, Rhoades S, Chen WF, Sengupta A, Yue Z, Lim JC, Mitchell CH, Weljie AM, Sehgal A. The Journal of biological chemistry. 2015 Aug 14;290(33):20407-16 Epub 2015 Jun 29 -
Sleep deprivation suppresses aggression in Drosophila.
Kayser MS, Mainwaring B, Yue Z, Sehgal A. eLife. 2015 Jul 28;4:e07643 -
Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt.
Weljie AM, Meerlo P, Goel N, Sengupta A, Kayser MS, Abel T, Birnbaum MJ, Dinges DF, Sehgal A. Proceedings of the National Academy of Sciences of the United States of America. 2015 Feb 24;112(8):2569-74 Epub 2015 Feb 9 -
Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus.
Jang AR, Moravcevic K, Saez L, Young MW, Sehgal A. PLoS genetics. 2015 Feb;11(2):e1004974 Epub 2015 Feb 12 -
Temperature oscillations drive cycles in the activity of MMP-2,9 secreted by a human trabecular meshwork cell line.
Li SK, Banerjee J, Jang C, Sehgal A, Stone RA, Civan MM. Investigative ophthalmology & visual science. 2015 Feb 5;56(2):1396-405 -
Heating and cooling the Drosophila melanogaster clock.
Maguire SE, Sehgal A. Current opinion in insect science. 2015 Feb 1;7:71-75 -
Methods in Enzymology. Circadian rhythms and biological clocks, part B. Preface.
Sehgal A. Methods in enzymology. 2015;552:xvii-xviii -
Methods in Enzymology. Circadian rhythms and biological clocks, part A. Preface.
Sehgal A. Methods in enzymology. 2015;551:xvii-xviii -
An ecdysone-responsive nuclear receptor regulates circadian rhythms in Drosophila.
Kumar S, Chen D, Jang C, Nall A, Zheng X, Sehgal A. Nature communications. 2014 Dec 16;5:5697 -
Casein kinase 1 promotes synchrony of the circadian clock network.
Zheng X, Sowcik M, Chen D, Sehgal A. Molecular and cellular biology. 2014 Jul;34(14):2682-94 -
Natural Populations of Drosophila melanogaster Reveal Features of an Uncharacterized Circadian Property: The Lower Temperature Limit of Rhythmicity.
Maguire SE, Schmidt PS, Sehgal A. Journal of biological rhythms. 2014 Jun;29(3):167-180 Epub 2014 Jun 10 -
Monoamines and sleep in Drosophila.
Nall A, Sehgal A. Behavioral neuroscience. 2014 Jun;128(3):264-72 -
Identification of a circadian output circuit for rest:activity rhythms in Drosophila.
Cavanaugh DJ, Geratowski JD, Wooltorton JR, Spaethling JM, Hector CE, Zheng X, Johnson EC, Eberwine JH, Sehgal A. Cell. 2014 Apr 24;157(3):689-701 -
A critical period of sleep for development of courtship circuitry and behavior in Drosophila.
Kayser MS, Yue Z, Sehgal A. Science (New York, N.Y.). 2014 Apr 18;344(6181):269-74 -
WIDE AWAKE mediates the circadian timing of sleep onset.
Liu S, Lamaze A, Liu Q, Tabuchi M, Yang Y, Fowler M, Bharadwaj R, Zhang J, Bedont J, Blackshaw S, Lloyd TE, Montell C, Sehgal A, Koh K, Wu MN. Neuron. 2014 Apr 2;82(1):151-66 Epub 2014 Mar 13 -
Day-night cycles and the sleep-promoting factor, Sleepless, affect stem cell activity in the Drosophila testis.
Tulina NM, Chen WF, Chen JH, Sowcik M, Sehgal A. Proceedings of the National Academy of Sciences of the United States of America. 2014 Feb 25;111(8):3026-31 Epub 2014 Feb 10 -
Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount.
Shi M, Yue Z, Kuryatov A, Lindstrom JM, Sehgal A. eLife. 2014;3:e01473 Epub 2014 Feb 4 -
New perspectives on circadian rhythms and sleep.
Saper CB, Sehgal A. Current opinion in neurobiology. 2013 Oct;23(5):721-3 Epub 2013 Jul 30 -
Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs.
Bartok O, Kyriacou CP, Levine J, Sehgal A, Kadener S. Proceedings. Biological sciences. 2013 Aug 22;280(1765):20130011 Epub 2013 Jul 3 -
Small-molecule screen in adult Drosophila identifies VMAT as a regulator of sleep.
Nall AH, Sehgal A. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 May 8;33(19):8534-40 -
Cooperative interaction between phosphorylation sites on PERIOD maintains circadian period in Drosophila.
Garbe DS, Fang Y, Zheng X, Sowcik M, Anjum R, Gygi SP, Sehgal A. PLoS genetics. 2013;9(9):e1003749 Epub 2013 Sep 26 -
Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness.
Joiner WJ, Friedman EB, Hung HT, Koh K, Sowcik M, Sehgal A, Kelz MB. PLoS genetics. 2013;9(9):e1003605 Epub 2013 Sep 5 -
Interaction between sleep and metabolism in Drosophila with altered octopamine signaling.
Erion R, DiAngelo JR, Crocker A, Sehgal A. The Journal of biological chemistry. 2012 Sep 21;287(39):32406-14 Epub 2012 Jul 24 -
Speed control: cogs and gears that drive the circadian clock.
Zheng X, Sehgal A. Trends in neurosciences. 2012 Sep;35(9):574-85 Epub 2012 Jun 28 -
Dopamine acts through Cryptochrome to promote acute arousal in Drosophila.
Kumar S, Chen D, Sehgal A. Genes & development. 2012 Jun 1;26(11):1224-34 Epub 2012 May 11 -
Old flies have a robust central oscillator but weaker behavioral rhythms that can be improved by genetic and environmental manipulations.
Luo W, Chen WF, Yue Z, Chen D, Sowcik M, Sehgal A, Zheng X. Aging cell. 2012 Jun;11(3):428-38 Epub 2012 Feb 24 -
Regulation of circadian behavioral output via a MicroRNA-JAK/STAT circuit.
Luo W, Sehgal A. Cell. 2012 Feb 17;148(4):765-79 Epub 2012 Feb 2 -
Genetics of sleep and sleep disorders.
Sehgal A, Mignot E. Cell. 2011 Jul 22;146(2):194-207 -
Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.
Hara T, Koh K, Combs DJ, Sehgal A. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Jul 6;31(27):9982-90 -
The circadian clock interacts with metabolic physiology to influence reproductive fitness.
Xu K, DiAngelo JR, Hughes ME, Hogenesch JB, Sehgal A. Cell metabolism. 2011 Jun 8;13(6):639-54 -
The central clock neurons regulate lipid storage in Drosophila.
DiAngelo JR, Erion R, Crocker A, Sehgal A. PloS one. 2011;6(5):e19921 Epub 2011 May 18 -
AKT and TOR signaling set the pace of the circadian pacemaker.
Zheng X, Sehgal A. Current biology : CB. 2010 Jul 13;20(13):1203-8 Epub 2010 Jun 17 -
Genetic analysis of sleep.
Crocker A, Sehgal A. Genes & development. 2010 Jun 15;24(12):1220-35 -
Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior.
Crocker A, Shahidullah M, Levitan IB, Sehgal A. Neuron. 2010 Mar 11;65(5):670-81 -
SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker.
Wu MN, Joiner WJ, Dean T, Yue Z, Smith CJ, Chen D, Hoshi T, Sehgal A, Koh K. Nature neuroscience. 2010 Jan;13(1):69-75 Epub 2009 Dec 13 -
The effects of caffeine on sleep in Drosophila require PKA activity, but not the adenosine receptor.
Wu MN, Ho K, Crocker A, Yue Z, Koh K, Sehgal A. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Sep 2;29(35):11029-37 -
An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator.
Zheng X, Koh K, Sowcik M, Smith CJ, Chen D, Wu MN, Sehgal A. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 Sep 2;29(35):10920-7 -
Energy stores are not altered by long-term partial sleep deprivation in Drosophila melanogaster.
Harbison ST, Sehgal A. PloS one. 2009 Jul 10;4(7):e6211 -
Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila.
Xu K, Zheng X, Sehgal A. Cell metabolism. 2008 Oct;8(4):289-300 -
Octopamine regulates sleep in drosophila through protein kinase A-dependent mechanisms.
Crocker A, Sehgal A. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Sep 17;28(38):9377-85 -
A Drosophila model for Angelman syndrome.
Wu Y, Bolduc FV, Bell K, Tully T, Fang Y, Sehgal A, Fischer JA. Proceedings of the National Academy of Sciences of the United States of America. 2008 Aug 26;105(34):12399-404 Epub 2008 Aug 13 -
Identification of SLEEPLESS, a sleep-promoting factor.
Koh K, Joiner WJ, Wu MN, Yue Z, Smith CJ, Sehgal A. Science (New York, N.Y.). 2008 Jul 18;321(5887):372-6 -
Identification of novel genes involved in light-dependent CRY degradation through a genome-wide RNAi screen.
Sathyanarayanan S, Zheng X, Kumar S, Chen CH, Chen D, Hay B, Sehgal A. Genes & development. 2008 Jun 1;22(11):1522-33 -
A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila.
Wu MN, Koh K, Yue Z, Joiner WJ, Sehgal A. Sleep. 2008 Apr;31(4):465-72 -
Quantitative genetic analysis of sleep in Drosophila melanogaster.
Harbison ST, Sehgal A. Genetics. 2008 Apr;178(4):2341-60 -
Probing the relative importance of molecular oscillations in the circadian clock.
Zheng X, Sehgal A. Genetics. 2008 Mar;178(3):1147-55 -
The circadian clock protein BMAL1 is necessary for fertility and proper testosterone production in mice.
Alvarez JD, Hansen A, Ord T, Bebas P, Chappell PE, Giebultowicz JM, Williams C, Moss S, Sehgal A. Journal of biological rhythms. 2008 Feb;23(1):26-36 -
Ac-ing the clock.
Sehgal A. Neuron. 2008 Jan 10;57(1):8-10 -
FOXO and insulin signaling regulate sensitivity of the circadian clock to oxidative stress.
Zheng X, Yang Z, Yue Z, Alvarez JD, Sehgal A. Proceedings of the National Academy of Sciences of the United States of America. 2007 Oct 2;104(40):15899-904 Epub 2007 Sep 25 -
Post-translational regulation of the Drosophila circadian clock requires protein phosphatase 1 (PP1).
Fang Y, Sathyanarayanan S, Sehgal A. Genes & development. 2007 Jun 15;21(12):1506-18 -
Interaction between sleep and the immune response in Drosophila: a role for the NFkappaB relish.
Williams JA, Sathyanarayanan S, Hendricks JC, Sehgal A. Sleep. 2007 Apr;30(4):389-400 -
Molecular analysis of sleep: wake cycles in Drosophila.
Sehgal A, Joiner W, Crocker A, Koh K, Sathyanarayanan S, Fang Y, Wu M, Williams JA, Zheng X. Cold Spring Harbor symposia on quantitative biology. 2007;72:557-64 -
A Drosophila model for age-associated changes in sleep:wake cycles.
Koh K, Evans JM, Hendricks JC, Sehgal A. Proceedings of the National Academy of Sciences of the United States of America. 2006 Sep 12;103(37):13843-7 Epub 2006 Aug 28 -
JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS.
Koh K, Zheng X, Sehgal A. Science (New York, N.Y.). 2006 Jun 23;312(5781):1809-12 -
Sleep in Drosophila is regulated by adult mushroom bodies.
Joiner WJ, Crocker A, White BH, Sehgal A. Nature. 2006 Jun 8;441(7094):757-60 -
A sleep-promoting role for the Drosophila serotonin receptor 1A.
Yuan Q, Joiner WJ, Sehgal A. Current biology : CB. 2006 Jun 6;16(11):1051-62 -
Serotonin modulates circadian entrainment in Drosophila.
Yuan Q, Lin F, Zheng X, Sehgal A. Neuron. 2005 Jul 7;47(1):115-27 -
The thymus is similar to the testis in its pattern of circadian clock gene expression.
Alvarez JD, Sehgal A. Journal of biological rhythms. 2005 Apr;20(2):111-21 -
Drosophila melanogaster: an insect model for fundamental studies of sleep.
Ho KS, Sehgal A. Methods in enzymology. 2005;393:772-93 -
Why a fly? Using Drosophila to understand the genetics of circadian rhythms and sleep.
Hendricks JC, Sehgal A. Sleep. 2004 Mar 15;27(2):334-42 -
Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A.
Sathyanarayanan S, Zheng X, Xiao R, Sehgal A. Cell. 2004 Feb 20;116(4):603-15 -
Pattern of distribution and cycling of SLOB, Slowpoke channel binding protein, in Drosophila.
Jaramillo AM, Zheng X, Zhou Y, Amado DA, Sheldon A, Sehgal A, Levitan IB. BMC neuroscience. 2004 Jan 27;5:3 -
Novel insights into the regulation of the timeless protein.
Ashmore LJ, Sathyanarayanan S, Silvestre DW, Emerson MM, Schotland P, Sehgal A. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Aug 27;23(21):7810-9 -
An abrupt shift in the day/night cycle causes desynchrony in the mammalian circadian center.
Nagano M, Adachi A, Nakahama K, Nakamura T, Tamada M, Meyer-Bernstein E, Sehgal A, Shigeyoshi Y. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Jul 9;23(14):6141-51 -
Non-cyclic and developmental stage-specific expression of circadian clock proteins during murine spermatogenesis.
Alvarez JD, Chen D, Storer E, Sehgal A. Biology of reproduction. 2003 Jul;69(1):81-91 Epub 2003 Feb 19 -
A fly's eye view of circadian entrainment.
Ashmore LJ, Sehgal A. Journal of biological rhythms. 2003 Jun;18(3):206-16 -
Circadian control of eclosion: interaction between a central and peripheral clock in Drosophila melanogaster.
Myers EM, Yu J, Sehgal A. Current biology : CB. 2003 Mar 18;13(6):526-33 -
Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster.
Hendricks JC, Lu S, Kume K, Yin JC, Yang Z, Sehgal A. Journal of biological rhythms. 2003 Feb;18(1):12-25 -
Circadian rhythms: finer clock control.
Alvarez JD, Sehgal A. Nature. 2002 Oct 24;419(6909):798-9 -
REV-ving up the clock.
Alvarez JD, Sehgal A. Developmental cell. 2002 Aug;3(2):150-2 -
Drosophila lacking dfmr1 activity show defects in circadian output and fail to maintain courtship interest.
Dockendorff TC, Su HS, McBride SM, Yang Z, Choi CH, Siwicki KK, Sehgal A, Jongens TA. Neuron. 2002 Jun 13;34(6):973-84 -
Signaling components that drive circadian rhythms.
Wang GK, Sehgal A. Current opinion in neurobiology. 2002 Jun;12(3):331-8 -
Restoration of circadian behavioural rhythms in a period null Drosophila mutant (per01) by mammalian period homologues mPer1 and mPer2.
Shigeyoshi Y, Meyer-Bernstein E, Yagita K, Fu W, Chen Y, Takumi T, Schotland P, Sehgal A, Okamura H. Genes to cells : devoted to molecular & cellular mechanisms. 2002 Feb;7(2):163-71 -
Molecular regulation of circadian rhythms in Drosophila and mammals.
Meyer-Bernstein EL, Sehgal A. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2001 Dec;7(6):496-505 -
A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis.
Hendricks JC, Williams JA, Panckeri K, Kirk D, Tello M, Yin JC, Sehgal A. Nature neuroscience. 2001 Nov;4(11):1108-15 -
Photic signaling by cryptochrome in the Drosophila circadian system.
Lin FJ, Song W, Meyer-Bernstein E, Naidoo N, Sehgal A. Molecular and cellular biology. 2001 Nov;21(21):7287-94 -
A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK.
Williams JA, Su HS, Bernards A, Field J, Sehgal A. Science (New York, N.Y.). 2001 Sep 21;293(5538):2251-6 -
Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock.
McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA. Cell. 2001 Jun 29;105(7):877-89 -
Regulation of the cycling of timeless (tim) RNA.
Wang GK, Ousley A, Darlington TK, Chen D, Chen Y, Fu W, Hickman LJ, Kay SA, Sehgal A. Journal of neurobiology. 2001 Jun 5;47(3):161-75 -
Role of molecular oscillations in generating behavioral rhythms in Drosophila.
Yang Z, Sehgal A. Neuron. 2001 Feb;29(2):453-67 -
Molecular components of the circadian system in Drosophila.
Williams JA, Sehgal A. Annual review of physiology. 2001;63:729-55 -
The need for a simple animal model to understand sleep.
Hendricks JC, Sehgal A, Pack AI. Progress in neurobiology. 2000 Jul;61(4):339-51 -
Altered entrainment and feedback loop function effected by a mutant period protein.
Schotland P, Hunter-Ensor M, Lawrence T, Sehgal A. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Feb 1;20(3):958-68 -
Rest in Drosophila is a sleep-like state.
Hendricks JC, Finn SM, Panckeri KA, Chavkin J, Williams JA, Sehgal A, Pack AI. Neuron. 2000 Jan;25(1):129-38 -
A role for the proteasome in the light response of the timeless clock protein.
Naidoo N, Song W, Hunter-Ensor M, Sehgal A. Science (New York, N.Y.). 1999 Sep 10;285(5434):1737-41 -
Oscillation and light induction of timeless mRNA in the mammalian circadian clock.
Tischkau SA, Barnes JA, Lin FJ, Myers EM, Barnes JW, Meyer-Bernstein EL, Hurst WJ, Burgoon PW, Chen D, Sehgal A, Gillette MU. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Jun 15;19(12):RC15 -
What makes the circadian clock tick: genes that keep time?
Sehgal A, Ousley A, Yang Z, Chen Y, Schotland P. Recent progress in hormone research. 1999;54:61-84; discussion 84-5 -
Alterations of per RNA in noncoding regions affect periodicity of circadian behavioral rhythms.
Chen Y, Hunter-Ensor M, Schotland P, Sehgal A. Journal of biological rhythms. 1998 Oct;13(5):364-79 -
Response of the timeless protein to light correlates with behavioral entrainment and suggests a nonvisual pathway for circadian photoreception.
Yang Z, Emerson M, Su HS, Sehgal A. Neuron. 1998 Jul;21(1):215-23 -
Conserved regions of the timeless (tim) clock gene in Drosophila analyzed through phylogenetic and functional studies.
Ousley A, Zafarullah K, Chen Y, Emerson M, Hickman L, Sehgal A. Genetics. 1998 Feb;148(2):815-25 -
Regulation of the Drosophila protein timeless suggests a mechanism for resetting the circadian clock by light.
Hunter-Ensor M, Ousley A, Sehgal A. Cell. 1996 Mar 8;84(5):677-85 -
Control of circadian rhythms by a two-component clock.
Sehgal A, Ousley A, Hunter-Ensor M. Molecular and cellular neurosciences. 1996 Mar;7(3):165-72 -
Molecular genetic analysis of circadian rhythms in vertebrates and invertebrates.
Sehgal A. Current opinion in neurobiology. 1995 Dec;5(6):824-31 -
Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL.
Gekakis N, Saez L, Delahaye-Brown AM, Myers MP, Sehgal A, Young MW, Weitz CJ. Science (New York, N.Y.). 1995 Nov 3;270(5237):811-5 -
Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation.
Sehgal A, Rothenfluh-Hilfiker A, Hunter-Ensor M, Chen Y, Myers MP, Young MW. Science (New York, N.Y.). 1995 Nov 3;270(5237):808-10 -
Positional cloning and sequence analysis of the Drosophila clock gene, timeless.
Myers MP, Wager-Smith K, Wesley CS, Young MW, Sehgal A. Science (New York, N.Y.). 1995 Nov 3;270(5237):805-8 -
Block in nuclear localization of period protein by a second clock mutation, timeless.
Vosshall LB, Price JL, Sehgal A, Saez L, Young MW. Science (New York, N.Y.). 1994 Mar 18;263(5153):1606-9 -
Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless.
Sehgal A, Price JL, Man B, Young MW. Science (New York, N.Y.). 1994 Mar 18;263(5153):1603-6 -
New short period mutations of the Drosophila clock gene per.
Baylies MK, Vosshall LB, Sehgal A, Young MW. Neuron. 1992 Sep;9(3):575-81 -
Ontogeny of a biological clock in Drosophila melanogaster.
Sehgal A, Price J, Young MW. Proceedings of the National Academy of Sciences of the United States of America. 1992 Feb 15;89(4):1423-7 -
Gene transfer of truncated NGF receptor clones leads to cell surface expression in mouse fibroblasts.
Sehgal A, Bothwell M, Chao M. Nucleic acids research. 1989 Jul 25;17(14):5623-32 -
A constitutive promoter directs expression of the nerve growth factor receptor gene.
Sehgal A, Patil N, Chao M. Molecular and cellular biology. 1988 Aug;8(8):3160-7 -
Efficient processing and expression of human nerve growth factor receptors in Xenopus laevis oocytes: effects on maturation.
Sehgal A, Wall DA, Chao MV. Molecular and cellular biology. 1988 May;8(5):2242-6 -
Expression and structure of the human NGF receptor.
Johnson D, Lanahan A, Buck CR, Sehgal A, Morgan C, Mercer E, Bothwell M, Chao M. Cell. 1986 Nov 21;47(4):545-54 -
The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias.
Huebner K, Isobe M, Chao M, Bothwell M, Ross AH, Finan J, Hoxie JA, Sehgal A, Buck CR, Lanahan A. Proceedings of the National Academy of Sciences of the United States of America. 1986 Mar;83(5):1403-7