Mariana Torrente is a post-doctoral researcher. She received dual bachelor’s degrees in Chemistry and Biochemistry from the Florida Institute of Technology in 2005 and her Ph.D. in Chemistry in 2010 from Princeton University where she comprehensively cataloged chromatin proteins -particularly histones- during biologically significant processes using high-end mass spectrometry proteomics. Prior to joining us as a PENN-PORT fellow, she was a NIH NRSA fellow at the Penn State University College of Medicine.
Torrente, M.P., L.M. Castellano, and J. Shorter. Suramin inhibits Hsp104 ATPase and disaggregase activity. PLoS ONE. In press. (2014).
Torrente, M.P., and J. Shorter. The metazoan protein disaggregase and amyloid depolymerase system: Hsp110, Hsp70, Hsp40, and small heat shock proteins. Prion. 7(6): 457-463. (2013). pdf file link
Ouedraogo, Y.P., Huang, L., Torrente, M.P., Proni, G., Chadwick, E., Wehmschulte, R.J., and Nesnas, N. A direct stereoselective preparation of a fish pheromone and application of the zinc porphyrin tweezer chiroptical protocol in its stereochemical assignment. Chirality. 25(9):575-81. (2013). pdf file link
Torrente, M.P, Freeman, W.M., and Vrana, K.V. Protein Biomarkers of Alcohol Abuse. Expert Reviews in Proteomics, 9(4), 425-36. (2012). pdf file link
Torrente, M.P, Gelenberg, A.J., and Vrana, K.V. Boosting serotonin in the brain: is it time to revamp the treatment of depression? J Psychopharmacol. 26(5), 629-35. (2012). pdf file link
Baliban, R.C., Dimaggio, P.A., Plazas-Mayorca, M.D., Garcia, B.A., Floudas, C.A. PILOT_PROTEIN: identification of unmodified and modified proteins via high-resolution mass spectrometry and mixed-integer linear optimization. J Proteome Res. 11(9), 4615-29. (2012). pdf file link
Torrente, M.P., Zee, B.M.; Young, N.L.; Baliban, R.C; Leroy, G.; Floudas, C.A.; Hake, S.B.; Garcia B.A., Proteomic Interrogation of Human Chromatin. PLoS One, 6, (9), e24747. (2011). pdf file link
Plazas-Mayorca, M.D. and Vrana, K.E. Proteomic investigation of epigenetics in neuropsychiatric disorders: A missing link between genetics and behavior? Journal of Proteome Research, 10 (1), 58–65. (2011). pdf file link
Plazas-Mayorca, M.D., Bloom, J.S., Zeissler, U., LeRoy, G., Young, N.L., DiMaggio, P.A., Krugylak, L., Schneider, R. and Garcia, B.A. Quantitative Proteomics Reveals Direct and Indirect Alterations in the Histone Code Following Methyltransferase Knockdown. Molecular BioSystems, (6), 1719-1729. (2010). pdf file link
Baliban, R. C.; DiMaggio, P. A.; Plazas-Mayorca, M.D.; Young, N. L.; Garcia, B. A.; Floudas, C. A., A novel approach for untargeted post-translational modification identification using integer linear optimization and tandem mass spectrometry. Molecular & Cellular Proteomics, 9, (5), 764-79. (2010). pdf file link
Young, N.L.*; Plazas-Mayorca, M.D.*; Flaniken, I.Z.; DiMaggio, P. A.; Beltran, A.; Mishra, N.; LeRoy, G.; Floudas, C. A.; Garcia, B.A., Collective mass spectrometry approaches reveal broad and combinatorial modification of high mobility group protein A1a.. Journal of the American Society for Mass Spectrometry, 21, (6), 960-70 (2010). *These authors contributed equally to this work. pdf file link
Young, N.L.; Plazas-Mayorca, M.D.; Garcia, B.A. Systems-wide proteomic characterization of combinatorial post-translational modification patterns. Expert Reviews in Proteomics, 7, (1), 79. (2010) . link
Plazas-Mayorca, M.D.; Zee, B.M.; Young, N.L.; Fingerman, I.M.; LeRoy, G.; Briggs, S.D.; Garcia B.A., One-pot shotgun quantitative mass spectrometry characterization of histones. Journal of Proteome Research, 8, (11), 5367-74. (2009). pdf file link
Young, N. L.; DiMaggio, P. A.; Plazas-Mayorca, M. D.; Baliban, R. C.; Floudas, C. A.; Garcia, B. A., High-throughput characterization of combinatorial histone codes. Molecular & Cellular Proteomics, 8, (10), 2266-84. (2009). pdf file link
Leroy, G.; Weston, J. T.; Zee, B. M.; Young, N. L.; Plazas-Mayorca, M. D.; Garcia, B. A., Heterochromatin protein 1 is extensively decorated with histone code-like post-translational modifications. Molecular & Cellular Proteomics, 8, (11), 2432-42. (2009). pdf file link