Pack Lab

Allan Pack and Mirek MackiewiczDr. Allan Pack is pursuing research on genetics/genomics of sleep apnea. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate whether there are genetic determinants to outcomes of sleep apnea, in particular, sleepiness. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Publications

Pack A, Pien GW. Update on Sleep and its Disorders. Ann Rev Med. 2010 Nov 8 [epub ahead of print].

Gooneratne NS, Bellamy SL, Pack F, Staley B, Schutte-Rodin S, Dinges DF, Pack AI. Case-control study of subjective and objective differences in sleep patterns in older adults with insomnia symptoms. J Sleep Res. 2010 Sept 30[epub ahead of print].

McShane BB, Galante RJ, Jensen ST, Naidoo N, Pack AI, Wyner A. Characterization of the bout durations of sleep and wakefulness. J of Neurosci Methods. 2010 Sept 15[epub ahead of print].

Mackiewicz M, Zimmerman JE, Shockley KR, Churchill GA, Pack AI. What are microarrays teaching us about sleep? Trends Mol Med. 2009 Feb;15(2):79-87.

Zimmerman JE, Raizen DM, Maycock MH, Maislin G, Pack AI. A video method to study Drosophila sleep. Sleep. 2008 Nov 1;31(11):1587-98.

Rotation Projects

Education

University of Glasgow, Scotland, 1967, MB, ChB
University of Glasgow, Scotland, 1976, PhD (Mathematical models of lung function)

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