Dr. Sigrid Veasey has developed a major program of research on oxidative injury neurons in murine models of obstructive sleep apnea (OSA), work that is ready for clinical translation.
Dr. Veasey’s laboratory focuses on neural injury incurred by hypoxia/reoxygenation events of obstructive sleep apnea. Over the past year her lab identified the specific wake active neuronal populations injured by hypoxia/reoxygenation, the two catecholaminergic groups the noradrenergic locus coeruleus and dopmainergic periacqueductal grey wake neurons. By comparing phenotypes and responses in these vulnerable to resistant wake neuronal populations, her group identified NADPH oxidase as a major contributor to the oxidative injury. Dr. Veasey is now comparing and contrasting these responses with other groups of neurons known to be injured in obstructive sleep apnea. The goal is to find major mechanisms of injury in hippocampal, hypothalamic and cortical neurons and then begin translational studies to identify the optimal overall pharmacotherapeutic approach to prevent or minimize neural injury in sleep apnea.
|Dr. Veasey with lab staff, from left, Yangpeng Li, MD, PhD; Guan Xia Zhan, MD; Yu-Ting Chou, MD; Lori Panossian, MD; Research Specialists Polina Fenik and Yan Zhu, MD.|
Moore JT, Chen J, Han B, Meng QC, Veasey SC, Beck SG, Kelz MB. Direct activation of sleep-promoting VLPO neurons by volatile anesthetics contributes to anesthetic hypnosis. Curr Biol. 2012 Nov 6;22(21):2008-16.
Veasey SC. Piecing together phenotypes of brain injury and dysfunction in obstructive sleep apnea. Front Neurol. 2012;3:139.
Panossian LA, Veasey SC. Daytime sleepiness in obesity: mechanisms beyond obstructive sleep apnea--a review. Sleep. 2012 May 1;35(5):605-15.
Li Y, Veasey SC. Neurobiology and neuropathophysiology of obstructive sleep apnea. Neuromolecular Med. 2012 Sep;14(3):168-79.
Veasey S. Sleep homeostasis: finding Odysseus among the mnesteres. Sleep. 2010 Sept 1;33(9):1131-2.
Veasey S. Treatment of obstructive sleep apnea. Indian J Med Res. 2010 Feb;131:236-44.
Veasey S. Insight from animal models into the cognnitive consequences of adult sleep-disordered breathing. ILAR J 2009;50(3):307-11
Zhu Y, Fenik P. Zhan G. Sanfillipo-Cohn B, Naidoo N, Veasey SC. Eif-2a protects brainstem motoneurons in a murine model of sleep apnea. J Neurosci. 2008 Feb 27;28(9):2168-78.
Zhu Y, Fenik P, Zhan G, Mazza E, Kelz M, Aston-Jones G, Veasey SC. Selective loss of catecholaminergic wake active neurons in a murine sleep apnea model. J Neurosci. 2007 Sep 12;27(37):10060-71.
Conduit R, Sasse A, Hodgson W, Trinder J, Veasey S, Tucker A. A neurotoxinological approach to the treatment of obstructive sleep apnea. Sleep Med Rev 2007 Oct. 11(5):361-75