Perelman School of Medicine at the University of Pennsylvania

Center for Sleep and Circadian Neurobiology

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Visiting International Scholars

The Center for Sleep and Circadian Neurobiology runs a robust visiting scholar program. Typically faculty or postdoctoral fellows spend one year with us on a specific research project. We have also hosted PhD students who did their research with us and completed their PhD in their home country. Visiting scholars have come from Brazil, China, Iceland, Taiwan and Thailand, Canada, Poland, Germany. At the recent meeting of the Chinese Sleep Research Society in Shanghai (2016) a whole symposium was presented by faculty who had been visiting scholars at the University of Pennsylvania. We have a robust program of research training in pediatric disorders directed by Dr. Carole Marcus. We also have a mini-fellowship program for psychologists to be trained in cognitive behavioral therapy for insomnia.

Prospective Scholars

Interested candidates who have completed relevant postgraduate training and have an interest in expanding their clinical knowledge of sleep medicine and pursuing sleep and circadian research may apply to become a visiting scholar. This unique opportunity will afford visiting scholars the opportunity to work with and under the mentorship of leading sleep and circadian experts at the University of Pennsylvania.

The goal of this program is to equip talented international scholars with the knowledge, experience, and skill set to further impact the field of sleep medicine and circadian neuroscience in their home countries.

  • Who: Applicants to this program are required to have completed graduate medical training (MD + residency/fellowship) and/or a graduate research degree (PhD) in their home country and have a keen interest in sleep and/or circadian neurobiology research. Scholars are typically funded by their home government or employer.
  • What: Each participant will have the opportunity to contribute meaningful research under supervision of a faculty mentor and observe various clinical settings. Opportunities vary depending on the availability of faculty and current research projects.
  • When: Applications are considered on a rolling basis throughout the year. Typically a scholar will commit to 12 months on campus (less or greater than 12 months will be considered on an individual basis).
  • How: To be considered for this program, please email Diane Lim, MD, MTR a letter of interest and current curriculum vitae at limdiane@mail.med.upenn.edu. In the letter of interest, please include what you hope to accomplish while here at Penn and what your goal is when you return back to your country. 
Please email Diane Lim, MD, MTR with any questions or inquiries.

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Dinges Lab Scholars

Janet Mullington, PhD

Dates of Training: 1996-1997

Topic of Study: Immune and inflammatory responses to sleep deprivation

Current position: Associate Professor of Neurology, Harvard Medical School; Associate Professor, Department of Neurology, Beth Israel Deaconess Medical Center

Publications Resulting from Training 

Shearer, W.T., Reuben, J.M., Mullington, J.M., Price, N.J., Lee, B.N., Smith, E.O., Szuba, M.P., Van Dongen, H.P., Dinges, D.F.: Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. Journal of Allergy & Clinical Immunology 107 (1):165-170, 2001.

Meier-Ewert, H.K., Ridker, P.M., Rifai, N., Price, N., Dinges, D.F., Mullington, J.M.: Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects. Clinical Chemistry 47 (3):426-430, 2001.

Van Dongen, H.P.A., Price, N.J., Mullington, J.M., Szuba, M.P., Kapoor, S.C., Dinges, D.F.: Caffeine eliminates psychomotor vigilance deficits from sleep inertia. SLEEP 24 (7):813-819, 2001.

Mullington, J.M., Chan, J.L., Van Dongen, H.P.A., Szuba, M.P., Samaras, J., Price, N.J., Meier-Ewert, H.K., Dinges. D.F., Mantzoros, C.S.: Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men. Journal of Neuroendocrinology 15: 851-854, 2003.

Van Dongen, H.P.A., Maislin, G., Mullington, J.M., Dinges, D.F.: The cumulative cost of additional wakefulness: Dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. SLEEP 26 (2):117-126, 2003.

Meier-Ewert, H., Ridker, P.M., Rifai, N., Regan, M.M.., Price, N., Dinges, D.F., Mullington, J.M.: Effects of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. Journal of the American College of Cardiology 43:678-683, 2004.


Hans P.A. Van Dongen, PhD

Dates of Training: 1998-1999

Topic of Study: Neurobehavioral effects of chronic sleep loss

Current position: Director, Sleep and Performance Research Center; Professor, Elson S. Floyd College of Medicine, Washington State University

Publications Resulting from Training   

Doran, S.M., Van Dongen, H.P., Dinges, D.F.: Sustained attention performance during sleep deprivation: evidence of state instability. Archives of Italian Biology: Neuroscience 139 (3):253-267, 2001.

Van Dongen, H.P.A., Price, N.J., Mullington, J.M., Szuba, M.P., Kapoor, S.C., Dinges, D.F.: Caffeine eliminates psychomotor vigilance deficits from sleep inertia. SLEEP 24 (7):813-819, 2001.

Van Dongen, H.P.A., Dinges, D.F.: Investigating the interaction between the homeostatic and circadian processes of sleep-wake regulation for the prediction of waking neurobehavioral performance. Journal of Sleep Research 12:181-187, 2003.

Van Dongen, H.P.A., Maislin, G., Mullington, J.M., Dinges, D.F.: The cumulative cost of additional wakefulness: Dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation. SLEEP 26 (2):117-126, 2003.

Olofsen, E., Dinges, D.F., Van Dongen, H.P.A.: Nonlinear mixed-effects modeling: Individualization and prediction. Aviation, Space and Environmental Medicine 75 (3):A134-A140, 2004.

Van Dongen, H.P.A., Baynard, M.D., Maislin, G., Dinges, D.F.: Systematic inter-individual variability differences in neurobehavioral impairment from sleep loss: Evidence of trait-like differential vulnerability. SLEEP 27(3): 423-433, 2004.


Siobhan Banks, PhD

Dates of Training: 2004-2005

Topic of Study: Physiological effects of sleep restriction and recovery

Current position: Senior Research Fellow Centre for Sleep Research, University of South Australia

Publications Resulting from Training

Banks, S., Dinges, D.F.: Behavioral and physiological consequences of sleep restriction. Journal of Clinical Sleep Medicine 3(5):519-528, 2007.

Goel, N., Banks, S., Mignot, E., Dinges, D.F.: PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation. PLoS ONE www.plosone.org 4(6):e5874, June 2009. 

Banks, S., Van Dongen, H.P.A., Maislin, G., Dinges, D.F. Neurobehavioral dynamics following chronic sleep restriction: Dose-response effects of one night for recovery. SLEEP 33(8):1013-1026, 2010.


Takashi Abe, PhD

Dates of Training: 2011-2013

Topic of Study: Workload, sleep loss and vigilance: Interaction and detection

Current position: Automotive Human Factors Research Center, National Institute of Advanced Industrial Science & Technology, Japan

Publications Resulting from Training               

Dinges, D.F., Abe, T. Transportation safety and operator sleepiness: Where biology needs technology. Proceedings of the International Association of Traffic and Safety Sciences (IATSS), 2013, pp. 88-120.

Goel, N., Abe, T., Braun, M.E., Dinges, D.F. Cognitive workload and sleep restriction interact to influence sleep homeostatic responses. SLEEP 37(11):1745-1756, 2014.

Abe, T., Mollicone, D., Basner, M., Dinges, D.F. Sleepiness and safety: where biology needs technology. Sleep and Biological Rhythms, 12:74-84, 2014.

Abe, T., Goel, N., Basner, M., Mollicone, D., Rao, H., Dinges, D.F. Integration of sleep need and fatigue mitigation into human system operation. In: F. Durso & D. Boehm-Davis, Handbook of Human Systems Integration, American Psychological Association, 2015, pp. 177-191.

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Gehrman Lab Scholars

Monika Sharma

Dates of Training: 2013

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Gooneratne Lab Scholars

Hakki Onen

Dates of Training: 2011-2012

Current position: Geriatrician and sleep specialist, Faculty of Medicine, Universite Claude-Bernard, Lyon Cedex, France


Fannie Onen

Dates of Training: 2009 & 2012

Current position: Attending, Clinical Researcher, University of Paris

 

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Kubin Lab Scholars

Richard L. Horner, PhD

Dates of Training: 1996-1997

Topic of Study: Carbachol model of REM sleep

Current position: Professor and Tier I Canada Chair; Dept. of Medicine, University of Toronto, Canada

Publications Resulting from Training 

Horner, R.L. and Kubin, L. 1999. Pontine carbachol elicits multiple rapid eye movement sleep-like neural events in urethane-anesthetized rats. Neuroscience 93:215-226.


Monika Malinowska, PhD

Dates of Training: 2001-2004

Topic of Study: Immunohistochemistry of brainstem pathways of REM sleep atonia in XII motoneurons

Current position: Senior Investigator, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland

Publications Resulting from Training   

Fenik, V.B., Malinowska, M., Davies, R.O. and Kubin, L. 2006. Medullary control of the upper airway during REM sleep. In:“Clinical and Neurophysiological Aspects of Sleep - Proceedings of the Interim Congress of the World Federation of Sleep Research and Sleep Medicine Societies (WFSRSMS), New Delhi, India, September 22-26, 2005", Kumar, V.M. and Mallick, H.N., Eds. Medimond, Bologna, pp. 47-53.

Volgin, D.V., Malinowska, M. and Kubin, L. 2009. Dorsomedial pontine neurons with descending projections to the medullary reticular formation express orexin-1 and adrenergic α2A receptor mRNA. Neurosci. Lett. 459:115-118.


Irma Rukhadze, PhD

Dates of training: 2005-2009

Topic of study: Aminergic pathways controlling hypoglossal motoneurons

Current position: Research Scientist, UCLA and VA Medical Center, Los Angeles, CA

Publications Resulting from Training   

Rukhadze, I. and Kubin, L. 2007. Mesopontine cholinergic projections to the hypoglossal motor nucleus. Neurosci. Lett. 413:121-125.

Rukhadze, I. and Kubin, L. 2007. Differential pontomedullary catecholaminergic projections to hypoglossal motor nucleus and viscerosensory nucleus of the solitary tract. J. Chem. Neuroanat. 33:23-33.

Rukhadze, I., Fenik, V.B., Branconi, J.L. and Kubin, L. 2008. Fos expression in pontomedullary catecholaminergic cells following REM sleep-like episodes elicited by pontine carbachol in urethane-anesthetized rats. Neuroscience 152:208-222.

Fenik, V.B., Rukhadze, I. and Kubin, L. 2008. Inhibition of pontine noradrenergic A7 cells reduces hypoglossal nerve activity in rats. Neuroscience 157:473-482.

Volgin, D.V., Rukhadze, I. and Kubin, L. 2008. Hypoglossal premotor neurons of the intermediate medullary reticular region express cholinergic markers. J. Appl. Physiol. 105:1576-1584.

Fenik, V.B., Rukhadze, I. and Kubin, L. 2009. Antagonism of α1-adrenergic and serotonergic receptors in the hypoglossal motor nucleus does not prevent motoneuronal activation elicited from the posterior hypothalamus. Neurosci. Lett. 462:80-84.

Rukhadze, I., Fenik, V.B., Benincasa, K.E., Price, A. and Kubin, L. 2010. Chronic-intermittent hypoxia alters density of aminergic terminals and receptors in the hypoglossal motor nucleus. Am. J. Respir. Crit. Care Med. 182:1321-1329.

Mody, P., Rukhadze, I. and Kubin, L. 2011. Rats subjected to chronic-intermittent hypoxia have increased density of noradrenergic terminals in the trigeminal sensory and motor nuclei. Neurosci. Lett. 505:176-179.

Rukhadze, I., Kamani, H. and Kubin, L. 2011. Quantitative differences among EMG activities of muscles innervated by subpopulations of hypoglossal and upper spinal motoneurons during non-REM sleep - REM sleep transitions: a window on neural processes in the sleeping brain. Arch. Ital. Biol. 149:499-515.

Stettner, G.M., Rukhadze, I., Mann, G.L., Lei, Y. and Kubin, L. 2013. Respiratory modulation of lingual muscle activity across sleep-wake states in rats. Respir. Physiol. Neurobiol. 188: 308-317.

Rukhadze, I., Kalter, J., Stettner, G.M. and Kubin, L. 2014. Lingual muscle activity across sleep-wake states in rats with surgically altered upper airway. Front. Neurol. 5, article 61.


Georg M. Stettner, MD, PhD

Dates of training: 2009-2012

Topic of study: Plasticity of upper airway motor control in rodent models

Current position: Head of Neuromuscular Section, Dept. of Pediatric Neurology, University Hospital, Zurich, Switzerland

Publications Resulting from Training   

Stettner, G.M., Fenik, V.B. and Kubin, L. 2012. Effect of chronic-intermittent hypoxia on noradrenergic activation of hypoglossal motoneurons. J. Appl. Physiol. 112:305-312.

Stettner, G.M. and Kubin, L. 2013. Antagonism of orexin receptors in the posterior hypothalamus reduces hypoglossal and cardiorespiratory excitation from the perifornical hypothalamus. J. Appl. Physiol. 114:119-130.

Benincasa Herr, K., Stettner, G.M. and Kubin, L. 2013. Reduced c-Fos expression in medullary catecholaminergic neurons in rats 20 h after exposure to chronic intermittent hypoxia. Am. J. Physiol. 304:R514-R522.

Stettner, G.M., Lei, Y., Benincasa Herr, K. and Kubin, L. 2013. Evidence that adrenergic ventrolateral medullary cells are activated whereas precerebellar lateral reticular nucleus neurons are suppressed during REM sleep. PLoS ONE 8(4): e62410.

Volgin, D.V., Stettner, G.M. and Kubin, L. 2013. Circadian dependence of receptors that mediate wake-related excitatory drive to hypoglossal motoneurons. Respir. Physiol. Neurobiol. 188:301-307.

Stettner, G.M., Rukhadze, I., Mann, G.L., Lei, Y. and Kubin, L. 2013. Respiratory modulation of lingual muscle activity across sleep-wake states in rats. Respir. Physiol. Neurobiol. 188: 308-317.

Volgin, D.V., Lu, J.W., Stettner, G.M., Mann, G.L., Ross, R.J., Morrison, A.R. and Kubin, L. 2014. Time- and behavioral state-dependent changes in posterior hypothalamic GABAA receptors contribute to the regulation of sleep. PLoS ONE 9(1):e86545.

Rukhadze, I., Kalter, J., Stettner, G.M. and Kubin, L. 2014. Lingual muscle activity across sleep-wake states in rats with surgically altered upper airway. Front. Neurol. 5, article 61.

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Kuna Lab Scholars

Qing Yun Li

Dates of training: 2013-2014

Topic of study: Validation of respiratory event detection by a positive airway pressure device

Current position: Department of Respiratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Publications Resulting from Training   

Li QY, Berry RB, Goetting MG, Soto-Calderon H, Tsai SC, Jasko JG, Pack AI, Kuna ST: Detection of upper airway status and respiratory events by a current generation positive airway pressure device. Sleep 38(4): 597-605, 2015.


Pongsakorn Tanayapong

Dates of training: 2016-2017

Topic of study: Heritability of sleep homeostasis

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Marcus Lab Scholars

Dr. Anchana Thongyam

Dates of training: 2011-2012

Current position: Pediatric Pulmonologist, Berapha University, Thailand

Publications Resulting from Training

A prospective study of post-operative complications of adenotonsillectomy in children with OSA

Thongyam A, Marcus CL, Lockman JL, Cornaglia MA, Caroff A, Gallagher PR, Shults J, Traylor JT, Rizzi MD, Elden L: Predictors of perioperative complications in higher risk children after adenotonsillectomy for obstructive sleep apnea: a prospective study. Otolaryngol Head Neck Surg 151(6): 1046-54, 2014.


Dr. Haibo Yuan

Dates of training: 2011-2012

Topic of study: PhD thesis on pathophysiology of OSA in children

Current position: Pulmonologist, The First Affiliated Hospital of Jilin University, China

Publications Resulting from Training

Yuan H, Swaroop P, Huang J, McDonough JM, Ward MB, Lee YN, Bradford RM, Gallagher PR, Shults J, Konstantinopoulou S, Samuel JM, Katz ES, Hua S, Tapia IE, Marcus CL: Ventilatory responses to hypercapnia during wakefulness and sleep in obese adolescents with and without obstructive sleep apnea syndrome. Sleep 35(9): 1257-67, Sep 2012.

Huang J, Pinto SJ, Yuan H, Katz ES, Karamessinis LR, Bradford RM, Gallagher PR, Hannigan JT, Nixon T, Ward MB, Lee YN, Marcus CL: Upper Airway Collapsibility and Genioglossus Activity in Adolescents during Sleep. Sleep 35(10): 1345-52, 2012.

Yuan H, Schwab RJ, Kim C, He J, Shults J, Bradford R, Huang J, Marcus CL: Relationship between body fat distribution and upper airway dynamic function during sleep in adolescents. Sleep 36(8): 1199-1207, August 2013.


Dr. Petrina Wong

Dates of training: 2013

Topic of study: Pediatric actigraphy

Current position: Pediatric Pulmonologist, KK Women’s and Children’s Hospital, Singapore          

Publications Resulting from Training

Meltzer LJ, Wong P, Biggs SN, Traylor J, Kim JY, Bhattacharjee R, Narang I, Marcus CL: Validation of actigraphy in middle childhood SLEEP 39(6): 1219-1224, 2016.


Dr. Danial Ko

Dates of training: 2015

Topic of study: Pediatric pulmonology and sleep medicine

Current position: Pediatric pulmonologist, Queen Elizabeth Hospital, Hong Kong


Stanislaw Boguslawski

Dates of training: 2016

Topic of study: Pediatric sleep medicine

Current position: Medical student, Medical University of Warsaw, Poland


Dr. Ming-Yu Chang

Dates of training: 2016

Topic of study: Pediatric sleep medicine

Current position: Pediatric neurologist, Chang Gung Children’s Hospital, Taoyuan, Taiwan


Dr. Eun Kyeong Kang

Dates of training: 2016

Topic of study: Pediatric sleep medicine

Current position: Pediatrician, Dongguk University Ilsan Hospital, Seoul, South Korea

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Pack Lab Scholars

Li-Pang Chuang

Dates of training: 2013

Current position: Chang Gung Memorial Hospital, Taipei


Yuan “Vivian” Feng

Dates of training: 2015-2016


Xiaoling Gao

Dates of training: 2015-2016

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Rao Lab Scholars

Sihua Xu, PhD

Dates of training: 2015-2017

Topic of study: Neuroimaging of sleep deprivation, depression, and decision making

Publications Resulting from Training   

Gui D, Xu S, Zhu S, Fang Z, Spaeth AM, Xin Y, Feng T, Rao H. 2015. Resting Spontaneous Activity in the Default Mode Network Predicts Performance Decline during Prolonged Attention Workload. NeuroImage. 120: 323-330.

Xu S, Pan Y, Wang Y, Spaeth AM, Qu Z, Rao H. 2016. Real and hypothetical monetary rewards modulate risk taking in the brain.<http://www.ncbi.nlm.nih.gov/pubmed/27383241> Scientific Reports. 6:29520.

Arya NG, Weissbart SJ, Xu S, Rao H. 2016. Brain activation in response to bladder filling in healthy adults: An activation likelihood estimation meta-analysis of neuroimaging studies.<http://www.ncbi.nlm.nih.gov/pubmed/27367364> Neurourol Urodyn. In press. doi: 10.1002/nau.23058.


Zhuo Fang, PhD

Dates of training: 2014-2015

Topic of study: Neuroimaging of sleep deprivation, fatigue, and addiction

Publications Resulting from Training   

Fang Z, Spaeth AM, Ma N, Zhu S, Hu S, Goel N, Detre JA, Dinges DF, Rao H. 2015. Altered salience network connectivity predicts macronutrient intake after sleep deprivation. Scientific Reports. 5: 8215.

Gui D, Xu S, Zhu S, Fang Z, Spaeth AM, Xin Y, Feng T, Rao H. 2015. Resting Spontaneous Activity in the Default Mode Network Predicts Performance Decline during Prolonged Attention Workload. NeuroImage. 120: 323-330.

Prehn K, Korczykowski M, Rao H, Fang Z, Detre JA, Robertson DC. 2015. Neural Correlates of Post-conventional Moral Reasoning: A Voxel-based Morphometry Study. PLoS One. 10(6):e0122914.

Wetherill RR, Fang Z, Jagannathan K, Childress AR, Rao H, Franklin TR. 2015. Cannabis, cigarettes, and their co-occurring use: disentangling differences in default mode network functional connectivity. Drug and Alcohol Dependence. 153:116-123.


Ning Ma, PhD

Dates of training: 2013-2015

Topic of study: Neuroimaging of sleep deprivation

Publications Resulting from Training   

Ma N, Dinges DF, Basner M, Rao H. 2015. How Acute Total Sleep Loss Affects the Attending Brain: A Meta-analysis of Neuroimaging Studies. SLEEP. 38(2):233-240.

Fang Z, Spaeth AM, Ma N, Zhu S, Hu S, Goel N, Detre JA, Dinges DF, Rao H. 2015. Altered salience network connectivity predicts macronutrient intake after sleep deprivation. Scientific Reports. 5: 8215.

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Veasey Lab Scholars

Stephen Robinson

Dates of training: 2010

Topic of study:  Neural injury in sleep apnea

Current position: Discipline Leader, Psychology at RMIT University, Melbourne, Australia

Publications Resulting from Training

Veasey SC, Lear J, Zhu Y, Grinspan JB, Hare DJ, Wang S, Bunch D, Doble PA, Robinson SR. Long-term intermittent hypoxia elevates cobalt levels in the brain and injures white matter in adult mice. Sleep. 2013 Oct 1;36(10):1471-81.


Yu-Ting Chou

Dates of training: 2010-2012

Topic of study:  CHOP-mediated oxidative stress in OSA

Current position:  Chang Gung Memorial Hospital, Chiayi, Taiwan

Publications Resulting from Training

Chou YT, Lee PH, Yang CT, Lin CL, Veasey S, Chuang LP, Lin SW, Lin YS, Chen NH. Obstructive sleep apnea: a stand-alone risk factor for chronic kidney disease. Nephrol Dial Transplant. 2011 Jul;26(7):2244-50.


Yanpeng Li

Dates of training: 2010-2011

Topic of study:  Wake neuron injury n sleep fragmentation

Current position:  Department of Neurology, Affiliated Changzheng Hospital, The Second Military Medical University, Shanghai, China

Publications Resulting from Training

Li Y, Panossian LA, Zhang J, Zhu Y, Zhan G, Chou YT, Fenik P, Bhatnagar S, Piel DA, Beck SG, Veasey S. Effects of chronic sleep fragmentation on wake-active neurons and the hypercapnic arousal response. Sleep. 2014 Jan 1;37(1):51-64.

Chou YT, Zhan G, Zhu Y, Fenik P, Panossian L, Li Y, Zhang J, Veasey S. C/EBP homologous binding protein (CHOP) underlies neural injury in sleep apnea model. Sleep. 2013 Apr 1;36(4):481-92.

Li Y, Veasey SC. Neurobiology and neuropathophysiology of obstructive sleep apnea. Neuromolecular Med. 2012 Sep;14(3):168-79


Jing Zhang

Dates of training: 2011-2012

Topic of study:  Sirtuin protection in sleep loss

Current position:  Department of Respiratory Medicine, Peking University, First Hospital, Beijing, China

Publications Resulting from Training

Zhang J, Zhu Y, Zhan G, Fenik P, Panossian L, Wang MM, Reid S, Lai D, Davis JG, Baur JA, Veasey S. Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons. J Neurosci. 2014 Mar 19;34(12):4418-31.

Li Y, Panossian LA, Zhang J, Zhu Y, Zhan G, Chou YT, Fenik P, Bhatnagar S, Piel DA, Beck SG, Veasey S. Effects of chronic sleep fragmentation on wake-active neurons and the hypercapnic arousal response. Sleep. 2014 Jan 1;37(1):51-64.

Zhang J, Peng H, Veasey SC, Ma J, Wang GF, Wang KW. Blockade of Na+/H+ exchanger type 3 causes intracellular acidification and hyperexcitability via inhibition of pH-sensitive K+ channels in chemosensitive respiratory neurons of the dorsal vagal nucleus in rats. Neurosci Bull. 2014 Feb;30(1):43-52.

Chou YT, Zhan G, Zhu Y, Fenik P, Panossian L, Li Y, Zhang J, Veasey S. C/EBP homologous binding protein (CHOP) underlies neural injury in sleep apnea model. Sleep. 2013 Apr 1;36(4):481-92.

Zhang J, Veasey S. Making sense of oxidative stress in obstructive sleep apnea: mediator or distracter? Front Neurol. 2012 Dec 27;3:179.


Pierre Charles Neuzeret

Dates of training: 2012

Current position: Manager, ResMed Science Center, Munich, Germany

Topic of study:  Neural injury in sleep apnea

Current position:  Manager, ResMed Science Center, Munich, Germany


Lei Yu

Dates of training: 2013-2014

Topic of research:  Orexin ethic neuron injury in sleep disruption

Current position:  Norman Bethune School of Medical Science, Jilin University, China


Xiang Ziang Zhao

Dates of training: 2015-2016

Topic of study:  Lead toxicity injury to wake neurons


Zhengqing Zhao

Dates of training: 2015-2017

Topic of study:  Tau injury to wake neurons from sleep disruption

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Insomnia Mini-Fellows

Kochav Bennaroch

Dates of training: 2016-2017

Topic of study: Behavioral Sleep Medicine

Current position: PhD Student, Nursing Dept., Haifa University, Haifa, Israel


Marie-Elaine Belanger, MD, FRCPC

Dates of training: 2015

Topic of study: Behavioral Sleep Medicine

Current position: Psychiatry Resident, Laval University, Quebec City, Canada


Allesandra Giordano, PhD

Dates of training: 2015

Topic of study: Behavioral Sleep Medicine

Current position: Rita Levi Montalcini Department of Neuroscience, University of Turin, Turin, Italy


Wan Sung Piu, APRN

Dates of training: 2014

Topic of study: Behavioral Sleep Medicine

Current position: Kwai Chung Hospital, Kwai Chung, Hong Kong

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Graduate Students

In addition, we have had graduate students spend time with us to conduct research that was part of their thesis in their home country. Erna Sif Arnardottir, from the University of Iceland, spent one year with us and was very productive. She has since returned to Reykjavik where she is on the faculty the Medical School. Renata Pellegrino also spent one year with us doing research that was part of her thesis from the University of Sao Paolo. Renata stayed in the United States and is currently the Director of the Sequencing Core at the Children’s Hospital of Philadelphia.


Erna Sif Arnardottir

Home Institution: University of Iceland

Current Position: Faculty, Medical School, University of Iceland

Publications

Björnsdóttir E, Benediktsdóttir B, Pack AI, Arnardottir ES, Kuna ST, Gíslason T, Keenan BT, Maislin G, Sigurdsson JF. The Prevalence of Depression among Untreated Obstructive Sleep Apnea Patients Using a Standardized Psychiatric Interview. J Clin Sleep Med. 2016 Jan;12(1):105-12. PubMed PMID: 26350608; PubMed Central PMCID: PMC4702203.

Bjornsdottir E, Keenan BT, Eysteinsdottir B, Arnardottir ES, Janson C, Gislason T, Sigurdsson JF, Kuna ST, Pack AI, Benediktsdottir B. Quality of life among untreated sleep apnea patients compared with the general population and changes after treatment with positive airway pressure. J Sleep Res. 2015 Jun;24(3):328-38. PubMed PMID: 25431105; PubMed Central PMCID: PMC4439289.

Arnardottir ES, Lim DC, Keenan BT, Maislin G, Benediktsdottir B, Juliusson S, Pack AI, Gislason T. Effects of obesity on the association between long-term sleep apnea treatment and changes in interleukin-6 levels: the Icelandic Sleep Apnea Cohort. J Sleep Res. 2015 Apr;24(2):148-59. PubMed PMID: 25359691; PubMed Central PMCID: PMC4351148.

Arnardottir ES, Nikonova EV, Shockley KR, Podtelezhnikov AA, Anafi RC, Tanis KQ, Maislin G, Stone DJ, Renger JJ, Winrow CJ, Pack AI. Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation. Sleep. 2014 Oct 1;37(10):1589-600. PubMed PMID: 25197809; PubMed Central PMCID: PMC4173916.

Ye L, Pien GW, Ratcliffe SJ, Björnsdottir E, Arnardottir ES, Pack AI, Benediktsdottir B, Gislason T. The different clinical faces of obstructive sleep apnoea: a cluster analysis. Eur Respir J. 2014 Dec;44(6):1600-7. PubMed PMID: 25186268.

Pak VM, Keenan BT, Jackson N, Grandner MA, Maislin G, Teff K, Schwab RJ, Arnardottir ES, Júlíusson S, Benediktsdottir B, Gislason T, Pack AI. Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. Int J Obes (Lond). 2015 Mar;39(3):472-9. PubMed PMID: 25042863; PubMed Central PMCID: PMC4302066.

Keenan BT, Maislin G, Sunwoo BY, Arnardottir ES, Jackson N, Olafsson I, Juliusson S, Schwab RJ, Gislason T, Benediktsdottir B, Pack AI. Obstructive sleep apnoea treatment and fasting lipids: a comparative effectiveness study. Eur Respir J. 2014 Aug;44(2):405-14. PubMed PMID: 24833762.

Björnsdóttir E, Janson C, Sigurdsson JF, Gehrman P, Perlis M, Juliusson S, Arnardottir ES, Kuna ST, Pack AI, Gislason T, Benediktsdóttir B. Symptoms of insomnia among patients with obstructive sleep apnea before and after two years of positive airway pressure treatment. Sleep. 2013 Dec 1;36(12):1901-9. PubMed PMID: 24293765; PubMed Central PMCID: PMC3825440.

Arnardottir ES, Janson C, Bjornsdottir E, Benediktsdottir B, Juliusson S, Kuna ST, Pack AI, Gislason T. Nocturnal sweating--a common symptom of obstructive sleep apnoea: the Icelandic sleep apnoea cohort. BMJ Open. 2013 May 14;3(5). pii: e002795. PubMed PMID: 23674447; PubMed Central PMCID: PMC3657640.

Arnardottir ES, Maislin G, Jackson N, Schwab RJ, Benediktsdottir B, Teff K, Juliusson S, Pack AI, Gislason T. The role of obesity, different fat compartments and sleep apnea severity in circulating leptin levels: the Icelandic Sleep Apnea Cohort study. Int J Obes (Lond). 2013 Jun;37(6):835-42. PubMed PMID: 22964793; PubMed Central PMCID: PMC3537909.

Arnardottir ES, Maislin G, Schwab RJ, Staley B, Benediktsdottir B, Olafsson I, Juliusson S, Romer M, Gislason T, Pack AI. The interaction of obstructive sleep apnea and obesity on the inflammatory markers C-reactive protein and interleukin-6: the Icelandic Sleep Apnea Cohort. Sleep. 2012 Jul 1;35(7):921-32. PubMed PMID: 22754038; PubMed Central PMCID: PMC3369227.

Maislin G, Ahmed MM, Gooneratne N, Thorne-Fitzgerald M, Kim C, Teff K, Arnardottir ES, Benediktsdottir B, Einarsdottir H, Juliusson S, Pack AI, Gislason T, Schwab RJ. Single slice vs. volumetric MR assessment of visceral adipose tissue: reliability and validity among the overweight and obese. Obesity (Silver Spring). 2012 Oct;20(10):2124-32. PubMed PMID: 22395811; PubMed Central PMCID: PMC3743719.

Arnardottir ES, Mackiewicz M, Gislason T, Teff KL, Pack AI. Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Sleep. 2009 Apr;32(4):447-70. Review. PubMed PMID: 19413140; PubMed Central PMCID: PMC2663860.

 

Renata Pellegrino

Home Institution: University of Sao Paolo

Current Position: Director of the Sequencing Core, Children’s Hospital of Philadelphia

Publications

Pellegrino R, Kavakli IH, Goel N, Cardinale CJ, Dinges DF, Kuna ST, Maislin G, Van Dongen HP, Tufik S, Hogenesch JB, Hakonarson H, Pack AI. A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans. Sleep. 2014 Aug 1;37(8):1327-36. Erratum in: Sleep. 2015 Nov;38(11):1827. PubMed PMID: 25083013; PubMed Central PMCID: PMC4096202.

Anafi RC, Pellegrino R, Shockley KR, Romer M, Tufik S, Pack AI. Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues. BMC Genomics. 2013 May 30;14:362. PubMed PMID: 23721503; PubMed Central PMCID: PMC3701596.

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