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Paid Studies

Unique Brainstem Biomarkers of Early Parkinson's Disease

Are you:

For more information please contact Christian Basile at the Smell and Taste Center of the Hospital of the University of Pennsylvania 215-662-2797. Please indicate when you call that you are calling about the Parkinson's Disease Study.

We are looking for ways to identify people with early Parkinson's disease (PD), a harmful brain illness. This could help us to diagnose PD sooner and to start treatments sooner, before too much brain damage occurs. In this study, we are testing sensory measurements that might be useful for this. The measurements we will use are smell tests and blink reflex tests. We will try to use these tests to tell apart healthy people, people with PD, and people with other neurological diseases.

Testing will take 1 day of your time. The blink reflex will be tested before and after a 2-hour period when you would rest while wearing goggles like very dark sunglasses. Before the blink reflex testing, you will do tests of smell identification, detection, and memory.

 

Current Studies NOT actively enrolling participants:

See below for details.

Postmenopausal Estrogen Influences on Olfaction

Funding source: National Institute on Aging, Richard L. Doty, Principal Investigator, RO1 AG17496

The goal of this study is to establish whether estrogen use in later life improves the ability to smell and affects memory and mood. Female volunteers 65 to 100 years of age who qualify will be administered (a) a questionnaire regarding prior medical history and hormone use and (b) tests of olfactory and cognitive function. Additionally, a small sample of blood is taken to establish current hormone levels, and permission is sought to allow our staff to review previous medical records. The 4-5 hour test session is performed at the convenience of the volunteer and $50.00 compensation is provided for participation. NOT actively enrolling participants.

For information, contact the office at 215-662-6582

Olfaction in Epilepsy

Funding source: National Institute on Deafness and Other Communication Disorders, Richard L. Doty, Principal Investigator, RO1 DC04278.

Patients with intractable epilepsy who are undergoing temporal lobe resection within the Philadelphia area are needed for this study. Such patients should be receiving their medical care either from the University of Pennsylvania Medical Center or from the Thomas Jefferson Medical Center in Philadelphia. The goal of this project is to better understand the nature of changes in olfaction and other sensory systems caused by epilepsy and temporal lobe resection for control of intractable seizures. The 4-5 hour test session is performed at the convenience of the volunteer and $50.00 compensation is provided for participation. NOT actively enrolling participants.

For information, contact the office at 215-662-6582

Hypnosis and the Perception of Odors

Funding source: PRODEV, Richard L. Doty, Principal Investigator.

Healthy subjects who are available for testing in Philadelphia until June 30th are needed for this study. You may qualify if you have no metal implants in your body (except dental amalgam), have no allergies to odorant's, and are not pregnant. The aim of this project is to examine the influence of suggestions given during a hypnosis session on the processing of olfactory stimuli in the brain. Eligible subjects will undergo several hypnosis sessions and magnetic resonance imaging. Subjects will be needed for 1-3 sessions of 1-2 hours each and will be compensated $50.00 if they complete 3 sessions. NOT actively enrolling participants.

 

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