University of Pennsylvania

The Smell and Taste Center

Center Home § Paid Studies

Paid Studies

Sensory Dysfunction in Early Parkinson’s Disease

Healthy older adults needed!

Are you:

For more information please contact the Smell and Taste Center of the Hospital of the University of Pennsylvania 215-662-6582.

Parkinson’s disease has been associated with altered sensory function, including changes in vision, hearing, smell, touch, taste, and balance.The purpose of this study is to better understand, using a wide range of tests, these sensory changes in early Parkinson’s disease.We will assess the relationships of the sensory changes to one another, the influence of dopamine therapy, a common treatment in early-stage Parkinson’s disease, on such changes, and the relationship of such changes to the number of dopamine nerve cells in a motor control region of your brain, determined using a procedure called Single Photon Emission Tomography (SPECT).During the SPECT part of this study, an Investigational New Drug (IND), termed TRODAT, will be employed.TRODAT is a chemical that is made to give off a form of light that can be seen by a special camera called a SPECT Scanner.The amount of light coming from any given area of the brain will show how much of the TRODAT material there is and the number of nerve cells that make a chemical called dopamine.

The Center needs volunteers for some of its human studies, a number of which are funded by the National Institutes of Health. All meet stringent government and University requirements for informed consent and the protection of human subjects. A listing, brief description, and administrative contact information for these studies are indicated below. Participation does not involve the use of experimental drugs.

 

Current Studies NOT actively enrolling participants:

See below for details.

Postmenopausal Estrogen Influences on Olfaction

Funding source: National Institute on Aging, Richard L. Doty, Principal Investigator, RO1 AG17496

The goal of this study is to establish whether estrogen use in later life improves the ability to smell and affects memory and mood. Female volunteers 65 to 100 years of age who qualify will be administered (a) a questionnaire regarding prior medical history and hormone use and (b) tests of olfactory and cognitive function. Additionally, a small sample of blood is taken to establish current hormone levels, and permission is sought to allow our staff to review previous medical records. The 4-5 hour test session is performed at the convenience of the volunteer and $50.00 compensation is provided for participation. NOT actively enrolling participants.

For information, contact the office at 215-662-6580

Olfaction in Epilepsy

Funding source: National Institute on Deafness and Other Communication Disorders, Richard L. Doty, Principal Investigator, RO1 DC04278.

Patients with intractable epilepsy who are undergoing temporal lobe resection within the Philadelphia area are needed for this study. Such patients should be receiving their medical care either from the University of Pennsylvania Medical Center or from the Thomas Jefferson Medical Center in Philadelphia. The goal of this project is to better understand the nature of changes in olfaction and other sensory systems caused by epilepsy and temporal lobe resection for control of intractable seizures. The 4-5 hour test session is performed at the convenience of the volunteer and $50.00 compensation is provided for participation. NOT actively enrolling participants.

For information, contact the office at 215-662-6580

Hypnosis and the Perception of Odors

Funding source: PRODEV, Richard L. Doty, Principal Investigator.

Healthy subjects who are available for testing in Philadelphia until June 30th are needed for this study. You may qualify if you have no metal implants in your body (except dental amalgam), have no allergies to odorant's, and are not pregnant. The aim of this project is to examine the influence of suggestions given during a hypnosis session on the processing of olfactory stimuli in the brain. Eligible subjects will undergo several hypnosis sessions and magnetic resonance imaging. Subjects will be needed for 1-3 sessions of 1-2 hours each and will be compensated $50.00 if they complete 3 sessions. NOT actively enrolling participants.

For information send an email to odor@gmx.at.

divider

About the Center & ContactResearch ProgramsPaid StudiesClinic For Smell and Taste Disorders • Staff {Faculty | Administration & Research Assistants} • Students {Past | Current} • News & Announcements • Publications {Papers | Book Chapters | Books} • Contribute To The CenterHome