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SOM Stimulus Information

Memorandum

To: School of Medicine Faculty
From: Glen N. Gaulton, Ph.D.
Date: January 7, 2010
Subject: NIH Announces the Availability of Recovery Act Funds for Comparative Effectiveness Research

I am writing to bring your attention to four new stimulus funding opportunities regarding comparative effectiveness research (CER). I encourage faculty who are doing research in these areas to investigate these funding opportunities carefully.

Additional information regarding CER criteria can found at: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-10-037.html

  • Recovery Act Limited Competition: Behavioral Economics for Nudging the Implementation of Comparative Effectiveness Research: Clinical Trials (RC4)
    • http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-10-001.html
    • Internal Deadline: 9:00 am, Wednesday, March 26, 2010 (e-submission to ORSS)
    • NIH Deadline: 5:00 pm, Wednesday, April 7, 2010
    • Purpose: The Recovery Act Limited Competition: Behavioral Economics for Nudging the Implementation of Comparative Effectiveness Research: Clinical Trials (RC4) invites applications proposing clinical trials using the principles of behavioral economics to enhance the uptake of the results of CER among health care providers in their practice. For this FOA, applicants must propose controlled trials that randomize units (whether individuals or clusters such as practices, hospitals, or larger units) to conditions, resulting in a randomized clinical trial (RCT) or cluster randomized trial (CRT).
  • Recovery Act Limited Competition: Behavioral Economics for Nudging the Implementation of Comparative Effectiveness Research: Pilot Research (RC4)
    • http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-10-002.html
    • Internal Deadline: 9:00 am, Friday, March 9, 2010 (e-submission to ORSS)
    • NIH Deadline: 5:00 pm, Friday, March 19, 2010
    • Purpose: The primary objective of the Recovery Act Limited Competition: Behavioral Economics for Nudging the Implementation of Comparative Effectiveness Research: Pilot Research (RC4) is to encourage the study of how the principles of behavioral economics could be used to enhance the uptake of the results of CER among health care providers in their practice. (For this FOA, applications should be thought of as large pilot or preliminary studies rather than definitive trials.) This funding opportunity seeks applications that will investigate whether the principles of behavioral economics could be used to enhance the uptake of the results CER among health care providers and also enhance the maintenance of such treatments in patient populations.
  • Recovery Act Limited Competition: Comparative Effectiveness Research on Upper Endoscopy in Gastroesophageal Reflux Disease (GERD), Eradication Methods for Methicillin Resistant Staphylococcus aureus (MRSA), and Dementia Detection and Management Strategies (RC4)
    • http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-10-008.html
    • Internal Deadline: 9:00 am, Friday, February 16, 2010 (e-submission to ORSS)
    • NIH Deadline: 5:00 pm, Friday, February 26, 2010
    • Purpose: The Recovery Act Limited Competition: Comparative Effectiveness Research on Upper Endoscopy in Gastroesophageal Reflux Disease (GERD), Eradication Methods for Methicillin Resistant Staphylococcus aureus (MRSA), and Dementia Detection and Management Strategies (RC4) invites applicants to conduct preliminary CER projects in targeted, high-priority areas in which such efforts have been lacking. (For this FOA, applications should be thought of as large pilot or preliminary studies rather than definitive trials.)
  • Recovery Act Limited Competition: Methodology Development in Comparative Effectiveness Research (RC4)
    • http://grants.nih.gov/grants/guide/rfa-files/RFA-OD-10-009.html
    • Internal Deadline: 9:00 am, Friday, February 16, 2010 (e-submission to ORSS)
    • NIH Deadline: 5:00 pm, Friday, February 26, 2010
    • Purpose: The primary objective of the Recovery Act Limited Competition: Methodology Development in Comparative Effectiveness Research (RC4) is to enhance, develop, or evaluate methodologies to improve the efficiency, validity, and credibility of comparative effectiveness research (CER) studies. CER encompasses a wide array of methodologies, including technology assessment, meta-analysis, systematic reviews, observational studies, and experimental trials. Each of these methodologies suffers from substantial weaknesses that limit their ability to rapidly provide information sought by patients, clinicians, and other stakeholders to make robust evidence-based decisions on clinical practice and public policy. Research is needed to develop better methods for measuring or reducing these weaknesses, which include, for example, confounding bias in observational studies and selection bias in randomized trials.

As always, please contact Susan Passante by phone at 898-0131 or by email at passante@mail.med.upenn.edu if you need any administrative help with developing or submitting a proposal.

Glen N. Gaulton, Ph.D.
Professor of Pathology and Laboratory Medicine
Executive Vice Dean and Chief Scientific Officer
University of Pennsylvania
Perelman School of Medicine
Tel: 215-898-2874 | Fax: 215-573-7945
Email: gaulton@mail.med.upenn.edu     

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