The following Penn faculty will be your professors, mentors, and guides during your time at the SUPERS@PENN program.

Dr. Stephen Tuttle SUPERS@PENN
Program Director

Dr. Tuttle has a Masters in Genetic Toxicology from case Western Reserve University and a Ph.D. in Biochemistry from the University of Pennsylvania. He moved to the Department of Radiation Oncology at Penn in 1986 with his thesis advisor and long time collaborator Dr. John Biaglow. Dr. Tuttle’s research focuses on the role of primary metabolic pathways and thiols in the cellular response to radiation response modifiers. More recently Dr. Tuttle has teamed with Dr. Costas Koumenis to study the ability of natural plant polyphenolics to act as radiation response modifiers. This collaboration began with their discovery that thioredoxin reductase 1, a key cellular protein thiol, can be directly targeted by natural Michael acceptors, such as curcumin and CAPE.

Outside of the research lab you will most likely find Dr. Tuttle on the tennis court playing doubles with several other members of the research faculty or on the second floor of Pottruck Gym.

Dr. Sydney Evans SUPERS@PENN

Dr. Sydney Evans attended Rutgers University for her undergraduate degree and then the University of Pennsylvania for her Veterinary (VMD) and Masters Degrees. She also completed an internship and residency in Radiation Oncology and Radiology at Penn. After over 20 years at Penn’s School of Veterinary Medicine, Dr Evans was recruited by the Department of Radiation Oncology at Penn’s School of Medicine as a scientific researcher. Her work has largely been at the crossroads between radiology and radiation oncology, studying methods to examine biological processes such as hypoxia (low tissue oxygen) and blood flow in tumors. Working with Dr. Cameron Koch, Dr.Evans was responsible for bringing the hypoxia diagnostic drug EF5 into human clinical trials.

Dr. Evans is very interested in mentoring students. She conceived the SUPERS program and along with Dr. Koumenis obtained the grant funding for this initiative.

Outside of work, Dr. Evans has 2 daughters, one a rising Junior at American University’s Kogod School of Business and the second, a Carnegie Mellon School of Design graduate currently living in New York City and working as a graphic designer/illustrator. Her hobbies are gardening, playing piano, reading and, when not injured, playing tennis.