| Projects > 2011 > Titas Banerjee

Role of Pattern Recognition Receptors in Breast Cancer Metastasis

Titas Banerjee
mentored by Dr. Andrew Minn

Hypothesis
Pattern recognition receptors (PRRs) lead to increased metastasis in breast cancer cells by enhancing inflammatory and metastasis genes.







Techniques
:: Cell Lines 231, 4175, 1833.
:: RNA Extraction.
:: Invasion Array.
:: Cell Culture.
:: Gene Silencing with siRNA.
:: Quantitative Reverse Transcriptase PCR.

Conclusions
:: PRRs play a significant role in invasion for certain metastatic breast cancer cell lines.
:: PRRs seem to regulate many known metastatic genes.