Projects
My work focuses on the pathogenesis of SBMA. Specifically, I am investigating the determinants of pathogenesis that lie within the androgen receptor, the gene mutated in SBMA. While the expanded polyglutamine tract that lies within the androgen receptor is intrinsically toxic, we believe that other domains within the protein, as well as post-translational modifications to these domains, may play critical roles in pathogenesis. Our Drosophila model of SBMA provides an ideal system in which to address these critical issues.
Personal Background
I received my B.A. in Biology and Psychology from Augustana College in Sioux Falls, SD, spending one year abroad at Trinity College Dublin. When not wrangling larvae in the lab, I enjoy cheese, steaks, and cheesesteaks, as well as local beers and BYOBs. Favorite activities include low-brow reading, high-brow reading, blog-reading, website-building, and all things music.
Publications
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Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Nedelsky NB, Schwartz SL, DiProspero NA, Knight MA, Schuldiner O, Padmanabhan R, Hild M, Berry DL, Garza D, Hubbert CC, Yao T-P, Baehrecke EH, Taylor JP. (2007) HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447, 859-863.
Education
- Augustana College, Sioux Falls, SD (B.A., 2004)
E-mail Natalia
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