Personal Background
I was raised in California and graduated from U.C Davis. I came to Philadelphia in 1987 for MD/PhD training and developed roots that have kept me here. I trained in Neurology at the Hospital of the University of Pennsylvania and in Neurogenetics with Kurt Fischbeck at the NINDS. In 2003, I returned to join the Neurology faculty at Penn and start my research lab.
Selected Publications (Basic Research)
- McCray BA, Taylor JP. (2008) The role of autophagy in age-related neurodegeneration. Neurosignals 16(1), 75-84. Link
- Pandey U.B., Batlevi Y., Baehrecke E.H., and Taylor J.P. (2007) HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system, and neurodegeneration. Autophagy 10;3(6).
- Pandey U.B., Nie Z., Batlevi Y., McCray B.A., Ritson G.P., Nedelsky N.B., Schwartz S.L., DiProspero N.A., Knight M.A., Schuldiner O., Padmanabhan R., Hild M., Berry D.L., Garza D., Hubbert C.C., Yao T-P, Baehrecke E.H., Taylor J.P. (2007) HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 447, 859-863.
- Guinto J.B., Ritson G.P., Taylor J.P., Forman M.S. (2007) Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy. Acta Neuropathol (Berl). In press
- Neumann M., Mackenzie I.R., Cairns N.J., Boyer P.J., Markesbery W.R., Smith C.D., Taylor J.P., Kretzschmar H.A., Kimonis V.E., Forman M.S. (2007) TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol. 66(2):152-7.
- Zeng, X-C., Bhasin, S., Wu, X., Lee, J-G., Maffi, S., Nichols, C.J., Taylor, J.P., Greene, L.E. and Eisenberg, E. (2004) Hsp70 dynamics in vivo: effect of heat shock and protein aggregation. J. Cell Sci. 117(21), 4991-5000.
- Piccioni, F., Romano, B., Fischbeck, K.H. and Taylor, J.P. (2004) A screen for drugs that protect against the toxicity of polyglutamine-expanded androgen receptor. Hum. Molec. Genet. 13(4), 437-446.
- Taylor, J.P., Tanaka, F., Robitschek, J., Markovic-Plese, S., Taye, A.A., Sandoval, C.M., and Fischbeck, K.H. (2003) Aggresomes protect cells by accelerating the degradation of polyglutamine-containing protein. Hum. Molec. Genet. 12(7), 749-757.
- Taylor, J.P., Taye, A.A., Campbell, C., Kazemi-Esfarjani, P., Fischbeck, K.H. and Min, K.T. (2003) Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein. Genes Dev. 17, 1463-1468.
- La Spada, A.R. and Taylor, J.P. (2003) Polyglutamines placed into context. Neuron 38, 681-684.
- Taylor, J.P., Hardy, J., and Fischbeck, K.H. (2002) Toxic proteins in neurodegenerative disease. Science 296(5575), 1991-1995.
- Sumner, C.J., Huynh, T., Markowitz, J.A., Coovert, D.D., Schussler, K., Jarecki, J., Burghes, A.H.M., Taylor, J.P. and Fischbeck, K.H. (2003) Valproic acid increases SMN levels in spinal muscular atrophy patient cells. Ann. Neurol. 54(5), 647-654.
- Taylor, J.P. and Fischbeck, K.H. (2002) Altered acetylation in polyglutamine disease: an opportunity for therapeutic intervention? Trends Mol. Med. 8(5), 195-197.
- Caplen, N.J., Taylor, J.P., Statham, V.S., Tanaka, F., Fire, A., and Morgan, R.A. (2002) Rescue of polyglutamine toxicity by dsRNA-mediated RNA interference in Drosophila and mammalian cells. Hum. Molec. Genet. 11, 175-184.
Selected Publications (Clinical)
- Di Prospero N.A., Sumner C.J., Penzak S.R., Ravina B., Fischbeck K.H., Taylor J.P. (2007) Safety, tolerability, and pharmacokinetics of high-dose idebenone in patients with friedreich ataxia. Arch Neurol. 64(6):803-8.
- Subramony, S.H., May, W., Lynch D.R., Gomez, C., Fischbeck, K.H., Hallett, M., Taylor, J.P., Wilson, R.L., Ashizawa, T. and the Cooperative Ataxia Group. Measuring Friedreich’s ataxia: inter-rater reliability of a neurologic rating scale. Neurology 64, 1261-1263.
- Di Prospero, N.A., Sumner, C.J., Penzak, S.R., Ravina, B., Fischbeck, K.H. and Taylor, J.P. Safety, tolerability, and pharmacokinetics of high dose idebenone administered to patients with Friedreich’s ataxia. Submitted
- Kolb, S. and Taylor, J.P. (2006) Spinal Muscular Atrophy. In: Neurogenetics: Scientific and Clinical Advances. Lynch, D.R. (ed.). Marcel Dekker, New York, NY, In press.
- Taylor, J.P., Galetta, S.L., Asbury, A.K., and Volpe, N.J. (2002) Hemolytic anemia presenting as idiopathic intracranial hypertension. Neurology, 59, 960-961.
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