Personal background
I joined the Taylor Lab as a Research Specialist to develop histopathological techniques for studying Drosophila models of neurodegenerative diseases. My background includes degrees in medicine, ultrastructural pathology, and neuropathology from the medical science training program in Yale-in-China Medical University, and more than ten years of histological experience at Penn. My work now involves establishing methods for morphological examination and protein immunolocalization in Drosophila compound eyes and brain. I am using these methods to help elucidate how mutations in VCP, TDP-43, and HDAC6 result in neurodegenerative disease.
Selected Publications (2002-2006)
- Bedrosian JC, Gratton MA, Brigande JV, Tang W, Landau J, Bennett J. In vivo delivery of recombinant viruses to the fetal murine cochlea: transduction characteristics and long-term effects on auditory function. Mol Ther. (In press).
- Zhang Z, Kostetskii I, Tang W, Haig-Ladewig L, Sapiro R, Wei Z, Patel AM, Bennett J, Gerton GL, Moss SB, Radice GL, Strauss JF 3rd. Deficiency of SPAG16L causes male infertility associated with impaired sperm motility. Biol Reprod. 2006 Apr;74(4):751-9.
- Keiser NW, Tang W, Wei Z, Bennett J. Spatial and temporal expression patterns of the choroideremia gene in the mouse retina. Mol Vis. 2005 Dec 7;11:1052-60.
- Wang F, Tang W, McGraw HM, Bennett J, Enquist LW, Friedman HM. Herpes simplex virus type 1 glycoprotein e is required for axonal localization of capsid, tegument, and membrane glycoproteins. J Virol. 2005 Nov;79(21):13362-72.
- Zhang Z, Jones BH, Tang W, Moss SB, Wei Z, Ho C, Pollack M, Horowitz E, Bennett J, Baker ME, Strauss JF 3rd. Dissecting the axoneme interactome: the mammalian orthologue of Chlamydomonas PF6 interacts with sperm-associated antigen 6, the mammalian orthologue of Chlamydomonas PF16. Mol Cell Proteomics. 2005 Jul;4(7):914-23.
- Lebherz C, Maguire AM, Auricchio A, Tang W, Aleman TS, Wei Z, Grant R, Cideciyan AV, Jacobson SG, Wilson JM, Bennett J. Nonhuman primate models for diabetic ocular neovascularization using AAV2-mediated overexpression of vascular endothelial growth factor. Diabetes. 2005 Apr;54(4):1141-9.
- Lebherz C, Auricchio A, Maguire AM, Rivera VM, Tang W, Grant RL, Clackson T, Bennett J, Wilson JM. Long-term inducible gene expression in the eye via adeno-associated virus gene transfer in nonhuman primates. Hum Gene Ther.2005 Feb;16(2):178-86.
- Dejneka NS, Kuroki AM, Fosnot J, Tang W, Tolentino MJ, Bennett J. Systemic rapamycin inhibits retinal and choroidal neovascularization in mice. Mol Vis. 2004 Dec 22;10:964-72.
- Wong WT, Rex TS, Auricchio A, Maguire AM, Chung D, Tang W, Bennett J. Effect of over-expression of pigment epithelium derived factor (PEDF) on developing retinal vasculature in the mouse. Mol Vis. 2004 Nov 8;10:837-44.
- Dejneka NS, Surace EM, Aleman TS, Cideciyan AV, Lyubarsky A, Savchenko A, Redmond TM, Tang W, Wei Z, Rex TS, Glover E, Maguire AM, Pugh EN Jr, Jacobson SG, Bennett J. In utero gene therapy rescues vision in a murine model of congenital blindness. Mol Ther. 2004 Feb;9(2):182-8.
- Surace EM, Auricchio A, Reich SJ, Rex T, Glover E, Pineles S, Tang W, O'Connor E, Lyubarsky A, Savchenko A, Pugh EN Jr, Maguire AM, Wilson JM, Bennett J. Delivery of adeno-associated virus vectors to the fetal retina: impact of viral capsid proteins on retinal neuronal progenitor transduction. J Virol. 2003 Jul;77(14):7957-63.
- Reich SJ, Fosnot J, Kuroki A, Tang W, Yang X, Maguire AM, Bennett J, Tolentino MJ. Small interfering RNA (siRNA) targeting VEGF effectively inhibits ocular neovascularization in a mouse model. Mol Vis. 2003 May 30;9:210-6.
- Yang JS, Ramanathan MP, Muthumani K, Choo AY, Jin SH, Yu QC, Hwang DS, Choo DK, Lee MD, Dang K, Tang W, Kim JJ, Weiner DB. Induction of inflammation by West Nile virus capsid through the caspase-9 apoptotic pathway. Emerg Infect Dis. 2002 Dec;8(12):1379-84.
Education
- M.D. (1982) Yale-in-China Medical University, Changsha, Hunan, P.R. China
- M.S. Ultrastructural Biology (1985) Yale-in-China Medical University, Changsha, Hunan, P.R. China
- Ph.D. Neuropathology (1989) Yale-in-China Medical University, Changsha, Hunan, P.R. China
E-mail Wai-Xing |
