I received my masters degree in biochemistry from the Dr. Ram Manohar Lohia Avadh University, Faizabad, India and PhD in medical genetics from the Sanjay Gandhi postgraduate institute of medical sciences, Lucknow India, where I studied molecular genetics of fragile X mental retardation in Indian population. I was interested in continuing my research on triplet repeat expansion disorders, so after obtaining my PhD, I joined the Taylor lab as postdoctoral fellow at the University of Pennsylvania, Philadelphia. At present I am studying the molecular pathogenesis of spinal and bulbar muscular atrophy (CAG expansion disease) using Drosophila as a model system.
Honors and Awards
___2007
- Selected for platform presentation “HDAC6 Rescues Neurodegeneration and Provides an Essential Link Between Autophagy and the UPS” at Annual Drosophila Meeting of the Genetics Society of America, Philadelphia, PA, March 7-11
- Travel award to present “Impairment of UPS and Induction of Autophagy in Spinobulbar Muscular Atrophy” at Keystone Symposia on Molecular Mechanisms of Neurodegeneration, Taos, New Mexico, Jan 16 - Jan 21
___2006
- Best poster award in The 5th Annual Biomedical Postdoc Research Symposium, University Of Pennsylvania, Philadelphia, PA dated 11th Oct
___2005
- Young Investigator travel award for participating in Gordon Research Conference on CAG triplet expansion diseases, South Hadley, Massachusetts, July 24 to 29th
- Best poster award in The 4th Annual Biomedical Postdoc Research Symposium, University Of Pennsylvania, Philadelphia, 21st Oct
- Best Poster award in Annual Marian S. Ware CNDR Retreat on Current Research in Neurodegenerative Diseases, University of Pennsylvania, Dec 12th
___2001
- Travel award for participating in 10th International workshop on fragile X and other X-linked mental retardation” to attend workshop in Rome, Italy during 16-21 Sept
___2000
- Best poster award in a National Scientific Conference held in Industrial Toxicological Research Center, Lucknow, India dated 12-13 Sept
___1999
- Best poster award in a symposium "Biological Chemistry Beyond 2000 AD" held in Dr RML Avadh University, Faizabad, India dated 18th - 21st Dec
Active Research Support
- Muscular Dystrophy Association “The role of HDAC6 in Drosophila model of spinal bulbar muscular atrophy”
Duration: 01/01/07-12/31/09
Role: Principle Investigator
- Kennedy’s Disease Association “The relationship between HDAC6 and autophagy in Drosophila model of spinal bulbar muscular atrophy”
Duration: 01/01/07-12/31/08
Role: Principle Investigator
Workshops and Training
- Short term training in Institute of Medical Genetics, Catholic University, Rome, Italy from 22nd September to 22 October 2001
- “10th International workshop on fragile X and other X-linked mental retardation” held in Frascati, Rome, Italy dated 17th – 21st Sept 2001
- “Indo-European Seminar cum Workshop on Advances of Cytogenetics” held in Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow. Dec 6-9, 1999.
Peer-reviewed Publications
- Pandey UB, Batlevi Y, Baehrecke EH, and Taylor JP. HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system, and neurodegeneration. Autophagy 2007 Sept 10;3(6).
- Pandey UB, Nie Z, Batlevi Y, McCray BA, Ritson GP, Schwartz SL, DiProspero N, Knight M, Schuldiner O, Padmanabhan R, Hild M, Berry DL, Garza D, Hubbert CC, Yao TP, Baehrecke EH, and Taylor JP. HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature 2007; 447: 859-63. See comment in Rubinsztein DC. Autophagy induction rescues toxicity mediated by proteasome inhibition. Neuron 2007; 54: 854-6.
- Pandey UB, Mittal B.Molecular basis of X-linked non-specific mental retardation. Indian J Exp Biol. 2004 Jun;42(6):549-57
- Pandey UB, Mittal B, Phadke S. Molecular diagnosis and genetic counseling of fragile X mental retardation. Neurol India. 2004 Mar;52(1):36-42
- Singh MK, Chetri K, Pandey UB, Kapoor VK, Mittal B, Choudhuri G. Mutational spectrum of K-ras oncogene among Indian patients with gallbladder cancer.J Gastro and Hepato, August 2004, vol. 19, iss. 8, pp. 916-921(6)
- Singh MK, Pandey UB, Ghoshal UC, Srivenu I, Kapoor VK, Choudhuri G, Mittal B. Apolipoprotein B-100 XbaI gene polymorphism in gallbladder cancer. Hum Genet. 2004 Feb;114(3):280-3
- Pandey UB. Response to Poon et al.-"FRAXAC1 and DXS548 polymorphisms in the Chinese population”. Am J Med Genet. 2003 Oct 1;122A(2):186
- Mittal B and Pandey UB. New Insights into the function of Fragile X mental retardation protein. ‘Hotspot’ Clinical Genetics. 62; 191-197; 2002
- Pandey UB, Phadke S, Mittal B. Molecular screening of FRAXA and FRAXE in Indian patients with unexplained mental retardation. Genet Test. 2002; 6: 335-9W
Book Chapter
Mittal B, Pandey UB, Phadke SR. Fragile - X - Mental Retardation. In, “Molecular and Cellular Neurobiology (M. K. Thakur and S. Prasad, Eds.”,(2005) pp.234, Narosa Publishing House, New Delhi, India.
Professional Membership
- Regular Member, Society for Neuroscience
- Member, Genetics Society of America
E-mail Udai
|
.