Meagan Rubel

Meagan Rubel

Graduate Student

Department of Genetics
Perelman School of Medicine
University of Pennsylvania
422 Clinical Research Building
415 Curie Boulevard
Philadelphia, PA 19104-6145
           

Research

I am broadly interested in the implications of how diet, subsistence practice, and environment are integrated with genetic variation, phenotypic adaptation, and health. My proposed PhD research will focus on gut microbiome and helminth analysis in African groups using human populations genetics and bioinformatics/statistical methods.

Education

Ph.D. Student

Molecular Anthropology, August 2011 – present
University of Pennsylvania, Philadelphia, PA 

Advisors: Drs. Sarah Tishkoff and Theodore Schurr

Masters in Public Health

December 2015
University of Pennsylvania, Philadelphia, PA
Advisor: Dr. Fran Barg

B.A. / B.I.S.

Anthropology
Interdisciplinary Studies Foci in Biology and Geography, August 2002 – December 2009
Arizona State University, Barrett Honors College, Tempe AZ

Research Experience

2011 – 2013

Molecular Anthropology Lab Member at University of Pennsylvania; working on “National Genographic Project” DNA sequencing and reconstruction of mtDNA, Y chromosome, and autosomal lineages for Native groups in Canada and Alaska

2010 – 2011

Molecular Anthropology Laboratory Manager at Arizona (see details below for projects)

2008 – 2009

Molecular Anthropology Laboratory Assistant at Arizona State University’s School of Human Evolution and Social Change; Worked on ancient DNA projects involving co-evolutionary trajectories of Mycobacterium tuberculosis, analyzed primate genomes for copy number variants, sequencing of informative SNPs for South American Y-STR diversity, sequencing and analysis of entire mtDNA of Abraham Lincoln’s relatives towards investigating ties to Marfan’s disease and other suspect genetic diseases, investigation of RUNX2 gene for influence in non-human primate cranial morphology and development.

2007 – 2009

Physical Collections Research Assistant at Arizona State University’s School of Human Evolution and Social Change; Analysis and inventory of physical collections within SHESC (1000+ individual remains), casting and processing for the Arizona State University Dental Anthropology System

2006

Archaeologist in the Mossel bay Archaeology Project with Dr. Curtis Marean, Institute of Human Origins (ASU); Excavation of Middle Stone Age Cave Sites in South Africa

2005 – 2007

Field/Lab Technician at Archeological Consulting Services; Cultural Site Survey, Historic Data Recovery at Hayden Flour Mill and Prehistoric Data Recovery at San Xavier Mission and Phoenix Metro Light Rail

2005

Archaeologist, Rio Salado Archaeology; Site survey, Data Xavier Mission and Valley Metro Light Rail with an emphasis on burial/inhumation recovery, Eligibility Testing, Project curation in accordance with ASM standards, Flotation, Soil Splitting, Document Management, Artifact Tracking and Labeling. Bioarchaeology at Las Canopas and Los Cremaciones, cremation and inhumation excavation

back to top

Grants

  • 2015
    • The Leakey Foundation Dissertation Grant for “Effect of Diet and Parasites on the Gut Metagenomics of Environmentally Diverse Africans.” Leakey Foundation Grantee Spotlight on Meagan Rubel
    • National Science Foundation Doctoral Dissertation Improvement Grant for "Gut Microbiomes of Cameroon Hunter-Gatherers: Roles of Diet and Helminths.”
    • Lewis and Clark Exploration for Fund for Exploration and Field Research for “Gut Microbiomes of Cameroon Hunter-Gatherers: Roles of Diet and Helminths.”
    • University of Pennsylvania Teece Fellowship Stipend for Research (5k) for “Gut Microbiomes of Cameroon Hunter-Gatherers: Roles of Diet and Helminths.”

Fellowships

    2017 - 2018: University of Pennsylvania Dissertation Completion Fellowship

    2016 - 2017: National Institute of Health T32 Training Fellowship in Parasitology

    2015 - 2016: Lewis and Clark Field Scholar

    2015 - 2016: Teece Fellowship for Dissertation Research

    2011: Moore Family Memorial Fellow

    2011 - current: University of Pennsylvania Benjamin Franklin Fellowship

Publications

  • 2017
    Rubel MA, Werner-Lin A, Barg FK, Berhardt BA (2017) Expert Knowledge Influences Decision-Making for Couples Receiving Positive Prenatal Chromosomal Microarray Testing Results. Culture, Medicine, and Psychiatry.
    PMID: 28132396
    (Electronically published ahead of print)

    Ritzman TB, Banovich N, Guida J, Rubel MA, Pinney J, Khang B, Ravosa MR, Stone AC (2017) Facing the facts: Changes in the Runx2 Gene Modulates Facial Morphology in Primates.  Journal of Human Evolution (Accepted)
  • 2016
    Rubel MA*, Holsbach-Beltrame M*, Tishkoff SA (2016) Inferences of African Evolutionary History from Genomic Data.Current Opinion in Genetics and Development. 41:159-166.
    *Co-first authorship
  • 2015
    Rubel MA, Werner-Lin A, Barg FK, Berhardt BA. (2015) Expert Knowledge Influences Decision-Making for Couples Receiving Positive Prenatal Chromosomal Microarray Testing Results. (Submitted).
  • 2014
    Cabana GS, Lewis Jr. CMJ, Tito RY, Covey A, Cáceres AM, Pampas LC, Quispe JC, De La Cruz AF, Durand D, Housman G, Hulsey BI, Iannaconne GC, López PW, Martinez R, Medina A, Rubel MA, Perry GH, Gerstein M, Stone AC (2014) Population Genetic Structure of Indigenous Populations of the Peruvian Central Andes. Human Biology 86(3):147-165.
  • 2012
    Iskow RC, Gokcumen O, Abyzov A, Malukiewicz J, Zhu Q, Sukumar AT, Pai AA, Mills RE, Habegger L, Cusanovich DA, Rubel MA, Perry GH, Gerstein M, Stone AC, Gilad Y, Lee C. Regulatory element copy number differences shape primate expression profiles. Proceedings of the National Academy of Sciences 109(31):12656-12661.

Posters

  • 2016
    Society for Molecular Biology and Evolution Dietary and Environmental Factors Shaping African Gut Microbiomes

    International Society for Evolution, Medicine, and Public Health,
    Diet, Environment, and Parasites: Factors Shaping Rural African Gut Microbiomes

    American Association of Physical Anthropologists
    , Environmental and Dietary Factors Shaping African Gut Microbiomes
  • 2015
    Rubel MA, Hansen MEB, Bailey A, Bittinger K, Laughlin A, Beggs W, Ranciaro A, Thompson SR, Bushman FD, TIshkoff SA. (2015) Role of Environment and Diet on Microbiome Composition in Diverse Rural Africans. [American Society for Human Genetics, Baltimore, MD.]
  • 2014
    Hansen MEB, Rubel MA, Bailey A, Bittinger K, Laughlin A, Beggs W, Ranciaro A, Thompson SR, Bushman FD, Tishkoff SA. Characterizing gut microbiota variation across diverse rural African populations. [American Society for Human Genetics, San Diego, CA]
    Rubel MA, Kellom K, Barg FK, Bernhardt BA. Expert Knowledge Shapes Decision-Making for Couples Receiving Uncertain Prenatal Chromosomal Microarray Testing Results. [American Society for Human Genetics, San Diego, CA]
  • 2012
    Ηarkins KM, Rubel MA, Pfister LA, Stone AC. Optimizing enrichment strategies for next-generation sequencing using ancient TB. [American Association of Physical Anthropologists, Portland, OR]
  • 2011
    Stone AC, Pfister LA, Harkins K, Campbell TJ, Rubel MA, Buikstra JE, and Wilbur AK. Next generation sequencing enrichment strategies for ancient tuberculosis: pitfalls and results. [American Association of Physical Anthropologists, Minneapolis, MN]
  • 2010
    Wilbur AK, Harkins K, Campbell TS, Rubel MA, Buikstra JE, and Stone AC, DNA analyses of ancient tuberculosis. [Society of Molecular Biology and Evolution meetings, Lyon, France]
  • 2009
    Rubel MA, Assessing musculoskeletal markers characteristic of militaryactivities: an analysis of sacrificial victims from Teotihuacan. [American Association of Physical Anthropologists,Chicago, IL]

    Pfister LA, Nash LT, Rubel MA, Rosenberg MS, Stone AC, Influence of the androgen receptor variation in primate and carnivore female social dominance. [American Association of Physical Anthropologists, Chicago, IL]

Oral Presentations

  • 2016
    Society for Molecular Biology and Evolution, Dietary and Environmental Factors Shaping African Gut Microbiomes

    International Society for Evolution, Medicine, and Public Health
    , Diet, Environment, and Parasites: Factors Shaping Rural African Gut Microbiomes
  • 2015
    Rubel MA, Barg FK, Werner-Lin A, Kellom K, Bernhardt BA. (2015) Expert Knowledge Influences Decision-Making for Couples Receiving Positive Prenatal Chromosomal Microarray Testing Results. [American Public Health Association. Chicago, IL]

Symposia Organized

  • 2017
    American Association of Physical Anthropologists
    , Symposium Co-Organizer (with Stephanie Schnorr): Humans as Holobionts: The Microbiome as a Biological System in Human Evolution

back to top