Welcome to the Titchenell Lab!
Our laboratory is located within the Institute for Diabetes, Obesity, and Metabolism and affiliated with the Department of Physiology at the Perelman School of Medicine at the University of Pennsylvania.
The Titchenell lab is focused on the regulation of metabolism by hormones and nutrients, with a particular emphasis on the master regulators of organismal physiology, insulin and glucose. Alterations in insulin and glucose signaling underlie metabolic disease and lead to the development of deadly vascular and neuronal complications. Over the last several years, our main focus has been on understanding the signaling mechanisms by which insulin regulates hepatic glucose and lipid metabolism. Through the use of various techniques encompassing molecular biology, biochemistry, metabolomics, transcriptional techniques and whole-animal physiology, we have unraveled several new mechanisms that define how insulin directly and indirectly (outside of the liver) regulates liver glucose and lipid metabolism.
Therefore, the long-term goals of our research program are to continue to explore and validate these pathways to define their contribution to organismal metabolism. Importantly, through the understanding of the basic mechanisms of hormone and nutrient signaling, we aim to identify the underlying mechanisms driving metabolic deregulation with the goal of identifying new therapies that improve metabolic control.
We are always looking for qualified and enthusiastic applicants interested in joining our team. In particular, individuals seeking opportunities at the postdoctoral level are encouraged to apply.
Penn BGS students are welcome for rotations. Dr. Titchenell is a member of the Cell and Molecular Biology and Biochemistry and Molecular Biophysics graduate groups.