The Translational Neuropathology Research Laboratory seeks to understand the molecular causes of age-related neurodegenerative diseases such as Alzheimer's disease, frontotemporal lobar dementia and amyotrophic lateral sclerosis. We use an interdisciplinary approach to address the mechanisms of neurodegeneration, including molecular, biochemical, histologic, physiologic and behavioral methods. We are also interested in using and developing cutting-edge techniques such as high-resolution, multi-spectral, 3-dimensional confocal imaging and next-generation sequencing. The laboratory is comprised of a collaborative group of inquisitive researchers, led by Eddie Lee, Assistant Professor in the Division of Neuropathology in the Department of Pathology and Laboratory Medicine. It is our mission to understand the root causes of human neurodegenerative diseases so that our discoveries can translate into specific disease-modifying therapies.