Publications

2013

Lee EB, Mattson MP. The neuropathology of obesity: insights from human disease. Acta Neuropathologica. In press.

Wood EM, Falcone D, Suh E, Irwin DJ, Chen-Plotkin AS, Lee EB, Xie S, Van Deerlin VM, Grossman M. Development and validation of pedigree classification for frontotemporal lobar degeneration. JAMA Neurology. In press.

Arnold SE, Toledo JB, Appleby DH, Xie SX, Wang LS, Baek Y, Wolk DA, Lee EB, Miller BL, Lee VM, Trojanowski JQ. A comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases. J Comp Neurol. In press.

Toledo JB, Van Deerlin VM, Lee EB, Suh E, Baek Y, Robinson JL, Xie SS, McBride J, Wood EM, Schuck T, Irwin D, Gross RG, Hurtig H, McCluskey L, Elman L, Karlawish J, Schellenberg G, Chen-Plotkin A, Wolk D, Grossman M, Arnold SE, Shaw LM, Lee VM-Y, Trojanowski JQ. A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank. Alzheimer's and Dementia. In press.

Brettschneider J, Tredicki, KD, Toledo JB, Robinson JL, Irwin DJ, Grossman M, Suh E, Van Deerlin VM, Wood EM, Baek Y, Kwong L, Lee EB, Elman L, McCluskey L, Fang L, Feldengut S, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Stages of pTDP-43 pathology in amyotrophic lateral sclerosis. Ann Neurol, 2013.

Lee EB, Russ J, Jung H, Elman LB, Chahine LM, Kremer D, Miller BL, Coslett HB, Trojanowski JQ, Van Deerlin VM, McCluskey LF. Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U. Acta Neuropathologica Communications. 1:9, May 2013.

2012

Yarchoan M, Xie SX, Kling MA, Toledo JB, Wolk DA, Lee EB, Van Deerlin V, Lee VM.-Y., Trojanowski JQ, Arnold SE. Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias. Brain. 135(12): 3749-56, Dec 2012.

Brettschneider J, van Deerlin V, Robinson J, Kwong L, Lee Edward B, Ali YO, Safren N, Monteiro M, Toledo JB, Elman L, McCluskey L, Irwin DJ, Grossman M, Molina L, Lee VMY, Trojanowski JQ.  Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion.  Acta Neuropathologica. 123(6): 825-39, Jun 2012.

Patel S, Lee EB, Xie SX, Law A, Jackson EM, Arnold SE, Clark CM, Shaw LM, Grady MS, Trojanowski JQ, Hamilton RH. Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus. Fluids Barriers CNS. 9(1): 7, Mar 2012.

Wang Sumei, Kim Sungheon, Zhang Yu, Wang Lu, Lee Edward B., Syre Peter, Poptani Harish, Melhem Elias R., Lee John Y.K.: Grading and subtyping of meningiomas using histogram analysis of diffusion tensor imaging. Radiology 262(2): 584-92, Feb 2012.

Lee Edward B and Ahima Rexford S. Alteration of hypothalamic cellular dynamics in obesity. The journal of clinical investigation. 122(1): 22-5, Jan 2012.

2011

Lee Edward B. Obesity, leptin and Alzheimer's disease. Annals of the New York academy of sciences. 1243(1): 15-29, Dec 2011.

Lee Edward B, Lee Virginia M.-Y. and Trojanowski John Q. Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nature reviews neuroscience 13(1): 38-50, Nov 2011.

Lee Edward B, Warmann Genevieve, Dhir Ravindra and Ahima Rexford S. Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity. Journal of neuroscience 31(40):14361-14366, October 2011.

Lee Edward B and Ahima Rexford S.: Central regulation of appetite and satiety behavior. Handbook of Behavior, Diet and Nutrition. Preedy VR (eds.). 2011

Lim Younshin, Kehm Victoria M, Lee Edward B, Soper James H, Li Chi, Trojanowski John Q, Lee Virginia M Y: Alpha-synuclein suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. Journal of neuroscience 31(27):10076-87, July  2011.

Winton Matthew J, Lee Edward B, Sun Eveline, Wong Margaret M, Leight Susan, Zhang Bin, Trojanowski John Q and Lee Virginia M-Y: Intraneuronal APP, not free A? peptides in 3xTg-AD mice: Implications for tau versus A?-mediated Alzheimer neurodegeneration. Journal of neuroscience 31(21): 7691-9, May 2011.

Igaz Lionel M*, Kwong Linda K*, Lee Edward B*, Chen-Plotkin Alice, Swanson Eric, Unger Travis, Malunda Joe, Xu Yan, Winton Matthew J, Trojanowski John Q, Lee Virginia M-Y: Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. The Journal of clinical investigation 121(2): 726-38, Feb 2011. PMCID: PMC3026736   *Co-lead authors

2009-2010

Hamilton Roy, Patel Sunil, Lee Edward B, Jackson Eric M, Lopinto Joanna, Arnold Steven E, Clark Christopher M, Basil Anuj, Shaw Leslie M, Xie Sharon X, Grady M Sean, Trojanowski John Q: Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology. Annals of neurology 68(4): 535-40, Oct 2010. PMCID: PMC2964442

Prasad Sashank, Lee Edward B, Woo John H, Alavi Abass, Galetta Steven L: Photo essay. MRI and positron emission tomography findings in Heidenhain variant Creutzfeldt-Jakob disease. Journal of neuro-ophthalmology 30(3): 260-2, Sep 2010. PMCID: PMC2964442

Arnold Steven E, Lee Edward B, Moberg Paul J, Stutzbach Lauren, Kazi Hala, Han Li-Ying, Lee Virginia M Y, Trojanowski John Q: Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease. Annals of neurology 67(4): 462-9, Apr 2010. PMCID: PMC2864948

Turkeltaub Peter E, Guzman Miguel A, Lee Edward B, Galetta Steven L: Idiopathic eosinophilic meningoencephalomyelitis following Well syndrome. Neurology 73(23): 2037-9, Dec 2009. PMCID: PMC2790232

Ranalli Nathan J, Huang Jason H, Lee Edward B, Zhang Paul J L, Siegelman Evan S, Zager Eric L: Hemangiomas of the brachial plexus: a case series. Neurosurgery 65(4 Suppl): A181-8, Oct 2009. PMCID: PMC2864948

Kim A K, Lee E B, Bagley L J, Loevner L A: Retained surgical sponges after craniotomies: imaging appearances and complications. AJNR. American journal of neuroradiology 30(6): 1270-2, Jun 2009. PMCID: PMC2790232

Lee Edward B, Tihan Tarik, Scheithauer Bernd W, Zhang Paul J, Gonatas Nicholas K: Thyroid transcription factor 1 expression in sellar tumors: a histogenetic marker? Journal of neuropathology and experimental neurology 68(5): 482-8, May 2009. PMCID: PMC2790232

Ko Melissa W, Turkeltaub Peter E, Lee Edward B, Gonatas Nicholas K, Volpe Nicholas J, Moster Mark L, Galetta Steven L: Primary diffuse leptomeningeal gliomatosis mimicking a chronic inflammatory meningitis. Journal of the neurological sciences 278(1-2): 127-31, Mar 2009. PMCID: PMC2790232

Neumann Manuela, Kwong Linda K, Lee Edward B, Kremmer Elisabeth, Flatley Andrew, Xu Yan, Forman Mark S, Troost Dirk, Kretzschmar Hans A, Trojanowski John Q, Lee Virginia M-Y: Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta neuropathologica 117(2): 137-49, Feb 2009. PMCID: PMC2693625

 

2007-2008

Prasad S, Moss H E, Lee E B, Glisson C C, Galetta S L: Clinical reasoning: a 42-year-old man with sequential monocular visual loss. Neurology 71(17): e43-9, Oct 2008. PMCID: PMC2693625

Lee Edward B, Lee Virginia M-Y, Trojanowski John Q, Neumann Manuela: TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system. Acta neuropathologica 115(3): 305-11, Mar 2008. PMCID: PMC2693625

Lee Edward B and Lee Virginia M.-Y.: Biology and molecular neuropathology of ?-amyloid protein. Neurobiology of Alzheimer's Disease, 3rd edition. Dawbarn D and Allen SJ (eds.). 2007.
Prasad Sashank, Ko Melissa W, Lee Edward B, Gonatas Nicholas K, Stern Matthew B, Galetta Steven: Supranuclear vertical gaze abnormalities in sporadic Creutzfeldt-Jakob disease. Journal of the neurological sciences 253(1-2): 69-72, Feb 2007. PMCID: PMC2693625

 

2005-2006

Lee Edward B, Leng Lewis Z, Zhang Bin, Kwong Linda, Trojanowski John Q, Abel Ted, Lee Virginia M-Y: Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. The Journal of biological chemistry 281(7): 4292-9, Feb 2006. PMCID: PMC2693625

Lee Edward B, Leng Lewis Z, Lee Virginia M-Y, Trojanowski John Q: Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis. FEBS letters 579(12): 2564-8, May 2005. PMCID: PMC2693625

Lazarov Orly, Morfini Gerardo A, Lee Edward B, Farah Mohamed H, Szodorai Anita, DeBoer Scott R, Koliatsos Vassilis E, Kins Stefan, Lee Virginia M-Y, Wong Philip C, Price Donald L, Brady Scott T, Sisodia Sangram S: Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. The Journal of neuroscience 25(9): 2386-95, Mar 2005.

Zhang Bin, Maiti Arpita, Shively Sharon, Lakhani Fara, McDonald-Jones Gaye, Bruce Jennifer, Lee Edward B, Xie Sharon X, Joyce Sonali, Li Chi, Toleikis Philip M, Lee Virginia M-Y, Trojanowski John Q: Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proceedings of the National Academy of Sciences of the United States of America 102(1): 227-31, Jan 2005. PMCID: PMC544048

Lee Edward B, Zhang Bin, Liu Kangning, Greenbaum Eric A, Doms Robert W, Trojanowski John Q, Lee Virginia M-Y: BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo. The Journal of cell biology 168(2): 291-302, Jan 2005. PMCID: PMC2171598

 

2002-2004

Sung Syaun, Yang Hengxuan, Uryu Kunihiro, Lee Edward B, Zhao Lei, Shineman Diana, Trojanowski John Q, Lee Virginia M-Y, Pratic? Domenico: Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. The American journal of pathology 165(6): 2197-206, Dec 2004. PMCID: PMC1618710

Watson Deborah J, Longhi Luca, Lee Edward B, Fulp Carl T, Fujimoto Scott, Royo Nicolas C, Passini Marco A, Trojanowski John Q, Lee Virginia M Y, McIntosh Tracy K, Wolfe John H: Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury. Journal of neuropathology and experimental neurology 62(4): 368-80, Apr 2003. PMCID: PMC1618710

Lee Edward B, Skovronsky Daniel M, Abtahian Farhad, Doms Robert W, Lee Virginia M-Y: Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons. The Journal of biological chemistry 278(7): 4458-66, Feb 2003. PMCID: PMC1618710

Passini Marco A, Lee Edward B, Heuer Gregory G, Wolfe John H: Distribution of a lysosomal enzyme in the adult brain by axonal transport and by cells of the rostral migratory stream. The Journal of neuroscience 22(15): 6437-46, Aug 2002. PMCID: PMC1618710

Contact Us

Translational Neuropathology
Research Laboratory
612 Stellar Chance Laboratories
422 Curie Blvd
Philadelphia, PA 19104
215-662-6696

News and Events

  • 6/3/2012 - Kathryn joins the lab for the summer. Welcome!

  • 5/11/2013 - Eddie recognized for his Alzheimer's research at the Alzheimer's Association Rita Hayworth Gala.

  • 4/1/2013 - Payal starts her lab rotation at TNRL. Welcome!

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