About the Center

"By increasing our understanding of the role of genetic factors in tobacco use and dependence, we hope to discover better ways to prevent smoking and to help people quit."

-Caryn Lerman, Ph.D.
Director

The mission of the University of Pennsylvania Transdisciplinary Tobacco Use Research Center (TTURC) is to translate discoveries in basic neuroscience, pharmacology, genetics, and behavioral science to improve treatment for nicotine dependence.

The PENN TTURC is currently conducting several primary research projects, as well as multiple pilot projects.

Primary Projects:

• The Role of CREB and Opioid System in Nicotine Reward
• Comparison of Standard Versus Extended Nicotine Patch Therapy for Smoking Cessation
• Improved Human Screening of Cessation Medications
• Effects of Atomoxetine on Cigarette Smoking

Pilot Projects:

• Effects of Atomoxetine on Nicotine Withdrawal & Sensory Gaiting
• Dopaminergic and Nicotinic Contributions to Bupropion-induced Alterations in Sensory and Motor Gating in Mice
• Smoking Topography and Smoke Exposure
• Neural Substrates of Food Reward in Deprived Smokers
• Neural and Genetic Substrates of Nicotine Deprivation Effects on Cognitive Performance: A Functional Neuroimaging Investigation
• Genetics and Nicotine Sensitivity: NRT Effect on Smoking Reinforcement by Genotype      

All of these focus on different aspects of smoking, genetics, prevention, and treatment. These studies draw upon the expertise of researchers from a variety of disciplines, including psychology, genetics, neuroscience, pharmacology, medicine, epidemiology, communication, and public policy.