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PARTNERS IN RESEARCH: CNDR || IOA || UDALL || Penn ADC
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Functional Consequences of Cognitive Impairment

Project Description

Faculty and Staff

Parkinson's disease studies at Penn

Advances in the Past Year

Publications

Andrew SiderowfAndrew Siderowf, MD, MSCE
Project Leader

Project Description

2010 Progress Report Update

Research dictionaryMethods for evaluating cognitive dysfunction in Parkinson’s disease (PD) and Parkinson’s disease dementia (PDD) have been largely borrowed from approaches developed for other dementing disorders, particularly Alzheimer’s disease. PD patients, however, have a specific profile of cognitive and motor impairments that differs from Alzheimer’s disease.

Penn Udall Center for Parkinson's Research Public Health StatementAs a result, a methodology specific to PD is needed to accurately classify cognitive features and to assess the impact of potential interventions. The purpose of this project is to address one aspect of this gap by developing a new clinical measurement tool, the “Functional Consequences of Cognitive Impairment” (FCCI) scale. The study and development of this scale has three aims: 1) to conduct qualitative studies to define specifically the functional consequences of cognitive impairment in PD; 2) to conduct detailed psychometric evaluations of the new FCCI; 3) to assess the validity of the FCCI in a longitudinal cohort study of PD patients. The study will produce a reliable measure of the impact of cognitive impairments in basic and instrumental daily functioning in PD and PDD patients. This instrument will also be valuable in clinical trials of cognitive interventions designed to treat or prevent PD.

Significant Scientific Advances in the Past Year

The study findings from this past year will result in the development of a feasible, reliable and valid rating scale that measures the functional consequences of cognitive impairment PD.  This instrument will be suitable for use in clinical trials of interventions designed to treat the cognitive impairments in PD, and will lead to a better understanding of the functional consequences of PD.

Faculty and Staff

Faculty

Andrew Siderowf, MD, MSCE

Project Leader
Henry A. Glick, PhD Judy Shea, PhD
Jason Karlawish, MD Daniel Weintraub, MD
Staff
Jacqui Rick  
Katia Duey, Research Coordinator  
Gene Peir, Research Coordinator

Publications