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PARTNERS IN RESEARCH: CNDR || IOA || UDALL || Penn ADC
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Mechanisms of Transmission of Pathological Alpha-Synuclein in Neurons

Virginia M-Y Lee Virginia M.-Y. Lee, PhD
Project Leader
   

Project Description

Parkinson's disease studies at PennThis project will test the hypothesis that neurons from different CNS regions are selectively vulnerable to develop either LBs/LNs alone or LBs/LNs with AD-like tau pathology and altered levels of secreted Abeta in response totreatment with distinct a-syn PFF strains.

The project will generate and characterize synthetic a-syn PFFs strains that differentially modulate the LBs/LNs and AD pathology and will determine if Penn Udall Center for Parkinson's Research Public Health Statementenriched LBs/LNs fractions isolated from different regions of PD/PDD/DLB brains, will differentially “seed” and “cross-seed” the recruitment of endogenous a-syn and tau into insoluble aggregates in primary neurons, thus reflecting strain-like properties..

Lastly, the project will collaborate with Project IV to identify anti-a-syn monoclonal antibodies (MAbs) that block a-syn transmission in neuron-based synucleinopathy models to be used for immunotherapy in a-syn Tg mice of Project IV.

Publications