Penn Udall Center Cores
The Penn Udall Center Team is divided into four cores, each responsible for a key area within the Center, and four project areas.
With funding from NINDS, the Penn Udall Center moves into its renewal period for years 6-10. For more information about the Penn Udall Center's Cores and its leaders, click on the core below. For more details on the current, individual projects being pursued at the Penn Udall Center, click on Projects below.
Administrative Core
The Administrative Core of the Penn Udall Center serves the important function of facilitating the accomplishment of the goals of this multidisciplinary research program. The aims of Core A are to oversee budgetary and fiscal aspects of the Penn Udall Center, promote and foster interactions between Core and Project investigators as well as interactions of Udall Center investigators with scientists at and beyond Penn, monitor the progress of the Cores and Projects, facilitate the sharing of data/reagents/resources generated by Penn Udall Center investigators with other researchers in accordance with NIH policies, and participate in annual Udall Center meetings to accelerate the pace of advances in understanding Parkinson's disease (PD) and Parkinson's disease with dementia (PDD). By utilizing the strategies in these aims, Core A will play an important administrative role in the Penn Udall Center by fostering the accomplishment of its research goals.
| John Q. Trojanowski, MD, PhD | Core Leader | |
| Kathryn Jedrziewski, PhD | Deputy Core Leader, Administration |
Click for Complete Recent Publications
Core Publications:
- Cramer, SC, Sur, M, O’Brien, C, Dobkin, BH, Sanger, TD, Trojanowski, JQ, Rumsey, JM, Hicks, R, Cameron, J, Chen, D, Chen, W, Cohen, L, deCharms, C, Duffy, CJ, Eden, GF, Fetz, EF, Filart, R, Freund, M, Grant, SJ, Haber, S, Kalivas, P, Kolb, B, Kramer, AF, Lynch, M, Mayberg, HS, McQuillen, PM, Nitkin, R, Pascual-Leone, A, Reuter-Lorenz, P, Schiff, N, Sharma, A, Shekim, A, Stryker, M, Sullivan, EV, Vinogradov, S. Harnessing neuroplasticity for clinical applications. Brain, 134:1591-1609, 2011. PMC3102236
- Khachaturian, ZS, Barnes, D, Einstein, R, Johnson S, Lee, VM-Y, Roses, A, Sager, MA, Shankle, WR, Snyder, PJ, Petersen, RC, Schellenberg, G, Trojanowski, JQ, Aisen, P, Albert, MS, Bernick, C, Breitner, JCS, Buckholtz, N, Carrillo, M, Ferris, S, Greenberg, BD, Grundman, M, Khachaturian, AS, Kuller, L, Lopez, O, Maruff, P, Mohs, RC, Morrison-Bogorad, M, Phelps, C, Phillips, M, Rao, S, Reiman, E, Sabbagh, M, Sano, M, Schiffer, R, Schneider, LS, Siemers, E, Tarriot, P, Touchon, J, Vellas, B, Bain, LJ. Developing a national strategy to prevent dementia: Leon Thal Symposium 2009. Alzheimer & Dementia, 6:89-97, 2010.
- Khachaturian, ZS, Snyder, PJ, Doody, R, Aisen, P, Comer, M, Dwyer, J, Frank, RA, Holzapfel, A, Khachaturian, AS, Korczyn, AD, Phelps, C, Roses, A, Simpkins, JW, Schneider, LS, Albert, MS, Egge, R, Deves, A, Ferris, S, Greenberg, BD, Johnson, C, Kukull, WA, Poirier, J, Schenk, D, Thies, W, Gauthier, S, Gilman, S, Bernick, C, Cummings, JL, Fillit, H, Grundman, M, Kaye, J, Mucke, L, Reisberg, B, Sano, M, Pickeral, O, Petersen, RC, Mohs, RC, Buckholtz, N, Carrillo, M, Corey-Bloom, JP, Foster, NL, Jacobsen, S, Lee, VM-Y, Potter, WZ, Sabbagh, MN, Salmon, D, Trojanowski, JQ, Wexler, N. (Reporter, Lisa J. Bain). A roadmap for the prevention of dementia II: Leon Thal Symposium 2008. Alzheimer & Dementia, 5:85-92, 2009.
- The Parkinson Progression Marker Initiative (PPMI). Parkinson Progression Marker Initiative. Prog. Neurobiol., 95:629-635, 2011.
- Trojanowski, J.Q. PENN neurodegenerative disease research - In the spirit of Benjamin Franklin. NeuroSignals, 16:5-10, 2008.
- Trojanowski, J.Q. (Editor, NeuroSignals Special Issue) Penn Neurodegenerative Disease Research – In The Spirit Of Ben Franklin. NeuroSignals, Volume 16, pages 1-105, 2008. Accepted prior to 4/7/08
- Trojanowski, JQ, Arnold, SE, Karlawish, JH, Brunden, K, Cary, M, Davatzikos, C, Detre, J, Gaulton, G, Grossman, M, Hurtig, H, Jedrziewski, K, McCluskey, L, Naylor, M, Polsky, D, Schellenberg, GD, Siderowf, A, Shaw, LM, Van Deerlin, V, Wang, L-S, Werner, R, Xie, SX, Lee, VM-Y. Lee. Design of comprehensive Alzheimer’s disease centers to address unmet national needs. Alzheimer’s & Dementia, 6:1150-155, 2010. PMC2842603
Clinical Core
The Clinical Core is responsible for recruiting and characterizing research subjects and obtaining research material. The Core will establish and characterize with regular physical, functional and neuropsychological assessments, a cohort of properly consented patients and controls who will: 1) participate in studies of PD, PDD and DLB; 2) donate blood for DNA extraction, plasma and CSF for chemical biomarker testing; and 3) promote brain donation from Udall participants to the Udall Center Core C.
Patients will be recruited to the Udall cohort from the Parkinson's Disease & Movement Disorders Center as well as other sources, including contacts made through outreach activities; control subjects will be recruited from families of patients, from senior centers in the Philadelphia area, and from other investigators in the affiliated Center for Neurodegenerative Disease Research (CNDR) research projects. Particular emphasis will be placed on recruiting women and minorities. These research subjects, their clinical data, biofluids and brain tissue will be utilized to conduct Projects I-IV of the Udall Center.
The Core will collaborate with Core C to investigate genetic factors in families of patients with at least one affected first degree relative with PD and will offer genetic counseling as described in Core C to all families who participate in the Udall Center’s programs.
The Core will collaborate with Core A to educate lay and professional referral sources on PD, PDD, DLB and related dementias in pursuit of recruiting a diverse patient population to participate in research as well as to train the next generation of PD researchers. Outreach efforts will include education for physicians and other healthcare providers, the regional PD community, and traditionally underserved minorities in the Philadelphia region at health fairs, senior centers and long-term care facilities. We also will collaborate with Core A and other Udall Center investigators to provide training in clinical research methods to post-doctoral fellows, residents and medical students.
The Core will contribute data to the clinical and tissue databases in cooperation with Core D, to resolve questions related to clinical data, and to facilitate the sharing of data with investigators in the Penn Udall Center and other Udall Centers. The Penn Udall Center database serves as the repository for all clinical, genetic, pathological and summarized imaging data collected at the Penn Udall Center. Core B will contribute these data to Core D and will work closely with Core D to resolve any questions related to data collection and storage. Likewise, Core B will provide all clinical data to Core C and Projects I-IV.
Additionally the Core will facilitate collaborations with other Udall Centers on standardization of sample collection and clinical characterization. We will continue and expand ongoing efforts, begun in collaboration with the University of Washington (UW) Udall Center, to develop and promulgate standardized clinical assessments of cognitive impairments (CI) and dementia in PD/PDD/DLB across the Udall network.
| Howard Hurtig, MD | Core Leader and Principal Investigator | |
| Rachel Gross, MD | Co-Core Leader |
Click for Complete Recent Publications
Core Publications
- Weintraub D, Xie S, Karlawish J, Siderowf A. Differences in Depression Symptoms in Patients with Alzheimer’s and Parkinson’s Diseases: Evidence From the 15-Item Geriatric Depression Scale (GDS-15). International J Geriat Psych, 22:1025-1030, 2007. PMC2085362
- Dahodwala N, Connolly J, Farmer J, Stern MB, Jennings D, Siderowf A. Interest in predictive testing for Parkinson’s disease: Impact of neuroprotective therapy. Park Relat Disord, 13:495-499, 2007.
- Nakashima-Yasuda H, Uryu K, Robinson J, Xie SX, Hurtig H, Duda J, Arnold SE, Siderowf A, Grossman M, Leverenz JB, Woltjer R, Lopez OL, Hamilton R, Tsuang DW, Galasko D, Masliah E, Kaye J, Clark CM, Montine TJ, Lee V M-Y, Trojanowski JQ. Co-Morbidity of TDP-43 proteinopathy in Lewy body related diseases. Acta Neuropathol,114: 221-229, 2007.
- Mamikonyan E, Siderowf AD, Duda JE, Potenza MN, Horn S, Stern MB, Weintraub D. Long-term follow-up of impulse control disorders in Parkinson’s disease. Mov Disord, 21 (3); 75-80, 2008. PMC2651355
- Connolly, J, Siderowf, A, Clark, CM, Mu, D, Pratico, D. F2 isoprostane levels in plasma and urine do not support increased lipid peroxidation in cognitively impaired Parkinson disease patients. Cog & Behav Neurol, 21:83-86, 2008.
- Nazem, S, Siderowf, AD, Duda, JE, Brown, GK, Ten Have, T, Stern, MB, Weintraub, D. Suicidal and death ideation in Parkinson's disease Movement Disorders. 23(11):1573-9, 2008. PMC2635951
- Goldman, R,, Siderowf, A, , Hurtig, HI. Cognitive impairment in Lewy Body disorders: A spectrum of disease. Neurosignals. 16:24-34 2008.
- Chen-Plotkin, AS, Yuan, W, Anderson, C, McCarty Wood, E, Hurtig. HI et al. Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations. Neurol, 2008:70:521-527.
- Covy. JP, Yuan. W, Waxman. EA, Hurtig. HI, Van Deerlin. VM, Giasson. BI. Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations. Mov Disord. 24:32-9, 2009. PMC2634827
- McCluskey, LF, Elman, LB, Martinez-Lage, M, Van Deerlin, V, Yuan, W., Clay, D, Siderowf, A, Trojanowski, JQ. Amyotrophic Lateral Sclerosis-plus syndrome with TAR DNA-binding protein-43 pathology. Arch Neurol, 66:121-124, 2009. PMC2702763
- Nazem, S, Siderowf, AD, Duda, JE, Have, TT, Colcher, A, Horn, SS, Moberg PJ, Wilkinson JR, Hurtig, HI, Stern, MB, Weintraub, D. Montreal cognitive assessment performance in patients with Parkinson's disease with "normal" global cognition according to mini-mental state examination score. J Amer Geriat Soc, 57:304-308, 2009. PMC2754699
- Mamikonyan, E, Moberg, PJ, Siderowf, A, Duda, JE, Ten Have, TR, Hurtig, HI, Stern, MB, Weintraub, D. Mild cognitive impairment is common in Parkinson's disease patients with normal Mini-Mental State Examination (MMSE) scores. Park Relat Disord, 15:226-231, 2009. PMC2668811
- Hoops, S, Nazem, S, Siderowf, AD, Duda, JE, Xie, SX, Stern, MB, Weintraub, D,. Validity of the MoCA and MMSE in the Detection of MCI and Dementia in Parkinson’s Disease. Neurol, 73:1738-45, 2009. PMC2788810.
- Mavandadi, S, Nazem, S, Ten Have, TR, Siderowf, AD, Duda, JE, Stern, MB, Weintraub, D. Use of latent variable modeling to delineate psychiatric and cognitive profiles in Parkinson disease. Am J Geriatr Psych, 17:986-95, 2009. PMC2848973
- Dahodwala, N, Xie, M, Noll, E, Siderowf, A, Mandell, DS. Treatment disparities in Parkinson's disease. Ann Neurol, 66:142-5, 2009. PubMed PMID: 19743462. PMC2856321
- Weintraub, D, Hoops, S, Shea, JA, Lyons, KE, Pahwa, R, Driver-Dunckley, ED, Adler, CH, Potenza, MN, Miyasaki, J, Siderowf, AD, Duda, JE, Hurtig, HI, Colcher, A, Horn, SS, Stern, MB, Voon, V. Validation of the questionnaire for impulsive-compulsive disorders in Parkinson's disease. Mov Disord, 24:1461-1467, 2009. PMC2848971
- Dahodwala, N, Siderowf, A, Xie, M, Noll, E, Stern, M, Mandell, DS. Racial differences in the diagnosis of Parkinson's disease. Mov Disord, 24:1200-1205, 2009. PubMed PMID: 19412929. PMC2858583
- Rosenthal, E, Brennan, L, Xie, SX, Hurtig, H, Milber, J, Weintraub, D, Karlawish, J, Siderowf, A. Association between cognition and function in Parkinson disease patients with and without dementia. Mov Disord, 25:1170-1176, 2010. PMC2963089
- Rao, H, Mamikonyan, E, Detre, JA, Siderowf, AD, Stern, MB, Potenza, MN, Weintraub, D. Decreased ventral striatal activity with impulse control disorders in Parkinson's disease. Mov Disord, 25:1660-1669, 2010. PMC3063061
- Stephenson, R, Houghton, D, Sundararajan, Sri, Doty, R, Stern, MB, Xie, SX, Siderowf, A. Odor identification deficits are associated with increased risk of neuropsychiatric complications in patients with Parkinson’s disease. Mov Disord, 25:2099-2104, 2010. PMC2963102
- Hu, WT, Chen-Plotkin, A, Arnold, SE, Grossman, M, Clark, CM, Shaw, LM, Pickering, E, Kuhn, M, Chen, Y, McCluskey, L, Elman, L, Karlawish, J, Hurtig, HI, Siderowf, A, Lee, VM, Soares, H, Trojanowski, JQ. Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment. Acta Neuropathol, 119:669-78, 2010. PMC2995537
- Siderowf, AD, Xie, S, Hurtig, HI, Weintraub, D, Duda, J, Chen-Plotkin, A, Shaw, L, Van Deerlin, V, Trojanowski, JQ, Clark, C. CSF amyloid abeta 1-42 predicts cognitive decline in Parkinson's disease. Neurol, 76:319-26, 2010. PMC2942062
- Weintraub, D, Mavandadi, S, Mamikonyan, E, Siderowf, AD, Duda, JE, Hurtig, HI, Colcher, A, Horn, SS, Nazem, S, Ten Have, TR, Stern, MB. Atomoxetine for depression and other neuropsychiatric symptoms in Parkinson’s disease. Neurol, 75:448-55, 2010. PMC2918470
- Hu, WT, Chen-Plotkin, A, Grossman, M, Arnold, SE, Clark, CM, Shaw, LM, McCluskey, L, Elman, L, Hurtig, HI, Siderowf, A, Lee, VM, Soares, H, Trojanowski JQ. Novel CSF biomarkers for frontotemporal lobar degenerations. Neurol, 75:2079-86, 2010. PMC2995537
- Papay, K, Mamikonyan, E, Siderowf, AD, Duda, JE, Lyons, KE, Pahwa, R, Driver-Dunckley, ED, Adler, CH, Weintraub, D. Patient versus informant reporting of ICD symptoms in Parkinson's disease using the QUIP: Validity and variability. Park Relat Disord, 17:153-155, 2010. PMC3073062
- Chen-Plotkin, AS, Hu, WT, Siderowf, A, Weintraub, D, Goldmann Gross, R, Hurtig, HI, Xie, SX, Arnold, SE, Grossman, M, Clark, CM, Shaw, LM, McCluskey, L, Elman, L, Van Deerlin, VM, Lee, VM, Soares, H, Trojanowski, JQ. Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease. Ann Neurol, 69: 2055-63, 2011. PMC3155276
- Xie, SX, Baek, Y, Grossman, M, Arnold, SE, Karlawish, J, Siderowf, A, Hurtig, H, Elman, L, McCluskey, L, Van Deerlin, V, Lee, VM-Y, Trojanowski, JQ. Building an integrated neurodegenerative disease database at an academic health center. Alz & Dem, 7:84-93, 2011. PMC3145967
- Dahodwala, N, Karlawish, J, Siderowf, A, Duda, JE, Mandel,l DS. Delayed Parkinson's disease diagnosis among African-Americans: the role of reporting of disability. Neuroepidem, 36:150-154, 2011 PMC3095837
- Morley, JF, Weintraub, D, Mamikonyan, E, Moberg, PJ, Siderowf, AD, Duda JE. Olfactory dysfunction is associated with neuropsychiatric manifestations in Parkinson's disease. Mov Disord. 26:2051-2057, 2011. PMC3168697
- Ash, S, McMillan, C, Gross, RG, Cook, P, Morgan, B, Boller, A, Dreyfuss, M, Siderowf, A, Grossman, M. The organization of narrative discourse in Lewy body spectrum disorder. Brain Lang, 119:30-41, 2011.
- Falcone, DC, Wood, EM, Xie, SX, Siderowf, AD, Van Deerlin, VM. Genetic testing and Parkinson’s disease: Assessment of patient knowledge, attitudes and interest J Genet Couns, 20:384-395, 2011.
- Martinez-Martin, P, Jeukens-Visser, M, Lyons, KE, Rodriguez-Blazquez, C, Selai, C, Siderowf, A, Welsh, M, Poewe, W, Rascol, O, Sampaio, C, Stebbins, GT, Goetz, CG, Schrag, A. Health-related quality-of-life scales in Parkinson's disease: Critique and recommendations. Mov Disord, 26:2371-2380, 2011.
- Weintraub, D, Doshi, J, Koka, D, Davatzikos, C, Siderowf, AD, Duda, JE et al. Neurodegeneration Across Stages of Cognitive Decline in Parkinson Disease. Arch Neurol, 68:1562-1568, 2011.
- Weintraub, D, Siderowf, AD, Troster, AI, Anderson, KE. “Parkinson’s disease and movement disorders” In Textbook of Geriatric Psychiatry. American Psychiatric Publishing, Inc. Arlington VA 2011, pp.569-599.
- Weintraub, D, Dietz, N, Duda, JE, Wolk, DA, Doshi, J, Xie, SX et al. Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's disease. Brain, In press, 2011.
- Gross, RG, McMillan, C, Dreyfuss, M, Ash, S, Avants, B, Cook, P, Libon, DJ, Siderowf, A, Grossman, M. Sentence processing in Lewy body spectrum disorder: The role of working memory. Brain Cogn, In press, 2012.
- Gross, RG, Moore, P, Dreyfuss, M, McMillan, CT, Cook, P, Ash, S, Siderowf A. Difficulty processing temporary syntactic ambiguities in lewy body spectrum disorder, Brain Lang, In press, 2011.
- Dahodwala, N, Siderowf, A, Baumgarten, M, Abrams, A, Karlawish, J. Screening questionnaires for parkinsonism: A systematic review. Park Relat Disord, In press, 2011.
Neuropathology, Biomarker, and Genetics Core
The Neuropathology, Biomarker, and Genetics Core acquires, preserves, and characterizes postmortem brain tissue and biological samples collected antemortem from clinically assessed control subjects as well as from patients with PD, PDD, DLB, and Lewy Body Variant of Alzheimer’s Disease (LBVAD).
The Core will conduct a postmortem examination on Udall Center patients with clinical PD, PDD or DLB and normal controls (NC) followed in Core B to establish a neuropathology (NP) diagnosis in each case. It will collect and bank biosamples, including postmortem CNS tissues, DNA, plasma and CSF for NP, biomarker (BMKR) and genetic studies on living and deceased NC and patients followed in Core B and studied in Projects I-IV of this Udall Center. It will maintain the Udall Center bank of biosamples from NC and PD/PDD/DLB patients, and distribute samples to investigators approved by the Executive Committee (EC) described in Core A. Additionally, the Core will archive NP, BMKR and genetics findings, and monitor all biosamples in a database in collaboration with Core D and the Udall Center’s PD Data Organizing Center (PD-DOC) or the equivalent when re-established, as well as provide advice and technical support to facilitate studies by Udall Center investigators and other scientists who use Core C resources.
| John Q. Trojanowski, MD, PhD | Core Leader | |
| Vivianna van Deerlin, MD, PhD | Core Co-Investigator |
Click for Complete Recent Publications
Core Publications
- Arnold, SE, Lee, E, Moberg, PJ, Stutzbach, L, Kazi, H, Han, L-Y, Lee, VM-Y, and Trojanowski, JQ. Aβ and PHFtau pathology in olfactory epithelium is increased in Alzheimer’s disease and correlates with brain pathology. Ann. Neurol., 67:462-469, 2010. PMC2864948
- Brunden, KR, Trojanowski, JQ, Lee, VM-Y. Advances in tau-focused drug discovery for Alzheimer’s disease and related tauopathies. Nat. Rev. Drug. Discov., 8:783-793, 2009. PMC2787222
- Cramer, SC, Sur, M, O’Brien, C, Dobkin, BH, Sanger, TD, Trojanowski, JQ, Rumsey, JM, Hicks, R, Cameron, J, Chen, D, Chen, W, Cohen, L, deCharms, C, Duffy, CJ, Eden, GF, Fetz, EF, Filart, R, Freund, M, Grant, SJ, Haber, S, Kalivas, P, Kolb, B, Kramer, AF, Lynch, M, Mayberg, HS, McQuillen, PM, Nitkin, R, Pascual-Leone, A, Reuter-Lorenz, P, Schiff, N, Sharma, A, Shekim, A, Stryker, M, Sullivan, EV, Vinogradov, S. Harnessing neuroplasticity for clinical applications. Brain, 134:1591-1609, 2011. PMC31102236
- Chen-Plotkin, A, Hu, WT, Siderowf, A, Weintraub, D, Goldmann Gross, R, Hurtig, HI, Xie, S, Arnold, SE, Grossman, M, Clark, CM, Shaw, LM, McCluskey, L, Elman, L, Karlawish, J, Van Deerlin, VM, Lee, VM-Y, Soares, H, and Trojanowski, JQ. Plasma EGF levels correlate with cognitive performance and predict cognitive impairment in Parkinson’s disease. Ann. Neurol., 69:655-663, 2010. PMC3155276
- Chen-Plotkin, A, Yuan, W, Anderson, C, McCarty-Wood, E, Hurtig, HI, Clark, CM, Miller, BL, Lee, VM-Y, Trojanowski, JQ, Grossman, M, Van Deerlin, V. Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations. Neurol., 70:52--527, 2008.
- Clinton, LK, Blurton-Jones, M, Trojanowski, JQ, LaFerla, FM. Synergistic interactions between Ab, tau, and alpha-synuclein: Acceleration of neuropathology and cognitive decline. J. Neurosci., 30:7281-7289, 2010.
- Covy, JP, Yuan, W, Waxman, EA, Hurtig, HI, Van Deerlin, VM, Giasson, BI. Clinical and pathological characteristics of patients with leucine-rich repeat kinase-2 mutations. Mov Disord. 24:32-9, 2009. PMC2634827
- Farmer, JM, McCarty-Wood, E, Lee, VM-Y, Trojanowski, JQ. An immortal legacy: How donation of human tissues impacts research and drives advances in diagnosis and therapy. In: A What If It’s Not Alzheimer’: A Caregiver’s Guide To Dementia, L. Radin and G. Radin (Eds.), Prometheus Books, New York, NY, pp. 129-144, 2008.
- Gao, H-M, Kotzbauer, PT, Uryu, K, Trojanowski, JQ, Lee, VM-Y. Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration. J. Neurosci., 28:7687-7698, 2008. PMC2702093
- Garbern, J, Neumann, M, Trojanowski, JQ, Lee, VM-Y, Feldman, G, Krajewski, KM, Norris, J, Friesz, M, Schwartz, C, Stevenson, R, Sima, AF. Mutation affecting the endosomal sodium-proton exchanger, SLC9A6, causes severe mental retardation with tau deposition X-linked non-syndromic mental retardation with tauopathy and corticobasal degeneration. Brain, 133:1391-1402, 2010. PMC2859154
- Geser, F, Winton, MJ, Kwong, LK, Xu, Y, Xie, SX, Igaz, LM, Garruto, R, Perl, D, Galasko, D, Lee, VM-Y, Trojanowski, JQ. Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. Acta Neuropath., 115:133-145, 2008.
- Giasson, BI, Van Deerlin, VM. Mutations in LRRK2 as a cause of Parkinson's disease. Neurosignals. 16:99-105, 2008.
- Gilman, S, Wenning, GK, Low, PA, Brooks, DJ, Mathias, CJ, Trojanowski, JQ, Wood, NW, Colosimo, C, Dürr, A, Fowler, CJ, Kaufmann, H, Klockgether, T, Lees, A, Poewe, W, Quinn, N, Revesz, T, Robertson, D, Sandroni, P, Seppi, K, Vidailhet, M. Second consensus statement on the diagnosis of multiple system atrophy. Neurol., 71:670-676, 2008. PMC2676993
- Höglinger, GU, Melhem, NM, Dickson, DW, Sleiman, PM, Wang, LS, Klei, L, Rademakers, R, de Silva, R, Litvan, I, Riley, DE, van Swieten, JC, Heutink, P, Wszolek, ZK, Uitti, RJ, Vandrovcova, J, Hurtig, HI, Gross, RG, Maetzler, W, Goldwurm S, Tolosa, E, Borroni, B, Pastor, P, PSP Genetics Study Group, Albin, RL, Alonso, E, Antonini, A, Apfelbacher, M, Arnold, SE, Avila, J, Beach, TG, Beecher, S, Berg, D, Bird, TD, Bogdanovic, N, Boon, AJ, Bordelon, Y, Brice, A, Budka, H, Canesi, M, Chiu, WZ, Cilia, R, Colosimo, C, De Deyn, PP, de Yebenes, JG, Kaat, LD, Duara, R, Durr, A, Engelborghs, S, Fabbrini, G, Finch, NA, Flook, R, Frosch, MP, Gaig, C, Galasko, DR, Gasser, T, Gearing, M, Geller, ET, Ghetti, B, Graff-Radford, NR, Grossman, M, Hall, DA, Hazrati, LN, Höllerhage, M, Jankovic, J, Juncos, JL, Karydas, A, Kretzschmar, HA, Leber, I, Lee, VM-Y, Lieberman, AP, Lyons, KE, Mariani, C, Masliah, E, Massey, LA, McLean, CA, Meucci, N, Miller, BL, Mollenhauer, B, Möller, JC, Morris, HR, Morris, C, O'Sullivan, SS, Oertel, WH, Ottaviani, D, Padovani, A, Pahwa, R, Pezzoli, G, Pickering-Brown, S, Poewe, W, Rabano, A, Rajput, A, Reich, SG, Respondek, G, Roeber, S, Rohrer, JD, Ross, OA, Rossor, MN, Sacilotto, G, Seeley, WW, Seppi, K, Silveira-Moriyama, L, Spina, S, Srulijes, K, St George-Hyslop, P, Stamelou, M, Standaert, DG, Tesei, S, Tourtellotte, WW, Trenkwalder, C, Troakes, C, Trojanowski, JQ, Troncoso, JC, Van Deerlin, VM, Vonsattel, JP, Wenning, GK, White, CL, Winter, P, Zarow, C, Zecchinelli, AL, Cantwell, LB, Han, MR, Dillman, A, van der Brug, MP, Gibbs, JR, Cookson, MR, Hernandez, DG, Singleton, AB, Farrer, MJ, Yu, CE, Golbe, LI, Revesz, T, Hardy, J, Lees, AJ, Devlin, B, Hakonarson, H, Müller U, Schellenberg, GD. Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy. Nat. Genet., 43:699-705, 2011. PMC3125476
- Hu, WT, Chen-Plotkin, A, Arnold, SE, Grossman ,M, Clark, CM, Shaw, LM, McCluskey, L, Elman, L, Karlawish, J, Hurtig, HI, Siderowf, A, Lee, VM-Y, Soares, H, Trojanowski, JQ. Biomarker discovery for Alzheimer’s disease, frontotemporal lobar degeneration, and Parkinson’s disease. Acta Neuropathol., 120:385-399, 2010.PMC2982700
- Jack, CR, Lexa, FJ, Trojanowski, JQ, Braffman, BH, Atlas, SW. Normal Aging, Dementia And Neurodegenerative Disease. In: Magnetic Resonance Imaging Of The Brain And Spine, S.W. Atlas (Ed.), 4th Edition, Lippincott Williams & Wilkins, Wolter Kluwer, Philadelphia, PA, pp. 1026-1086, 2009.
- Jedrziewski, MK, Ewbank, DC, Wang, H, Trojanowski, JQ. Exercise and cognition: Results from the National Long Term Care Survey. Alzheimer’s & Dementia, 6:448-455, 2010. PMC1950132
- Khachaturian, ZS, Barnes, D, Einstein, R, Johnson S, Lee, VM-Y, Roses, A, Sager, MA, Shankle, WR, Snyder, PJ, Petersen, RC, Schellenberg, G, Trojanowski, JQ, Aisen, P, Albert, MS, Bernick, C, Breitner, JCS, Buckholtz, N, Carrillo, M, Ferris, S, Greenberg, BD, Grundman, M, Khachaturian, AS, Kuller, L, Lopez, O, Maruff, P, Mohs, RC, Morrison-Bogorad, M, Phelps, C, Phillips, M, Rao, S, Reiman, E, Sabbagh, M, Sano, M, Schiffer, R, Schneider, LS, Siemers, E, Tarriot, P, Touchon, J, Vellas, B, Bain, LJ. Developing a national strategy to prevent dementia: Leon Thal Symposium 2009. Alzheimer & Dementia, 6:89-97, 2010.
- Khachaturian, ZS, Snyder, PJ, Doody, R, Aisen, P, Comer, M, Dwyer, J, Frank, RA, Holzapfel, A, Khachaturian, AS, Korczyn, AD, Phelps, C, Roses, A, Simpkins, JW, Schneider, LS, Albert, MS, Egge, R, Deves, A, Ferris, S, Greenberg, BD, Johnson, C, Kukull, WA, Poirier, J, Schenk, D, Thies, W, Gauthier, S, Gilman, S, Bernick, C, Cummings, JL, Fillit, H, Grundman, M, Kaye, J, Mucke, L, Reisberg, B, Sano, M, Pickeral, O, Petersen, RC, Mohs, RC, Buckholtz, N, Carrillo, M, Corey-Bloom, JP, Foster, NL, Jacobsen, S, Lee, VM-Y, Potter, WZ, Sabbagh, MN, Salmon, D, Trojanowski, JQ, Wexler, N (Reporter, Lisa J Bain). A roadmap for the prevention of dementia II: Leon Thal Symposium 2008. Alzheimer & Dementia, 5:85-92, 2009.
- Lee, SE, Wilson, S, Seeley, WW, Rankin, KP, DeArmond, S, Huang, E, Trojanowski, JQ, Growdon, ME, Jang, J, Sidhu, M, See, T, Karydas, A, Jagust, WJ, Weiner, M, Gorno-Tempini, M-L, Boxer, AL, Miller, BL, Rabinovici, GD. Correlates of Alzheimer’s disease pathology in corticobasal syndrome. Ann Neurol, 70:327-340, 2011.
- Leverenz, J.B., Hamilton, R., Tsuang, D.W., Schantz, A., Vavrek, D., Larson, E.B., Kukull, W.A., Lopez, O., Galasko, D., Masliah, E., Kaye, J., Woltjer, R.., Clark, C., Trojanowski, J.Q., Montine, T.J. Empirical refinement of pathologic assessment of lewy-related pathology in dementia patient. Brain Pathol., 18:220-224, 2008 PMC2689097
- Lim, Y., Kehm, V., Lee, E.B., Soper, J., Li, C., Trojanowski, J.Q., Lee, V.M.-Y. Alpha-synuclein suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. J. Neurosci., 31:10076-10087, 2011. PMC3144489
- Lim, Y, Kehm, V, Li, C, Trojanowski, JQ, Lee, V MY. Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption. Exper Neurol, 221:86-97, 2010. PMC2812632
- Lippa, CF, Duda, JE, Grossman, M, Hurtig, H, Aarsland, D, Boeve, B, Brooks,DJ, Dickson, DW, Dubois, B, Emre, M, Fahn, S, Farmer, J, Galasko, D, Galvin, JE, Goetz, C, Growdon, JH, Gwinn-Hardy, KA, Hardy, J, Heutink, P, Iwatsubo, T, Kosaka, K, Lee, VMY, Leverenz, J, Masliah, E, McKeith, IE, Nussbaum, RL, Olanow, CW, Ravina, BM, Singleton, AB, Tanner, CM, Trojanowski, JQ, Wszolek, ZK, DLB/PDD Working Group. DLB and PDD boundary issues: Diagnosis, treatment, molecular pathology and biomarkers. Neurol, 68:812-819, 2007.
- Luk, CK, Hyde, EG, Trojanwowski, JQ, Lee, VMY. Sensitive fluorescence polarization technique for rapid screening of alpha-synuclein oligomerization/ fibrillization inhibitors. Biochem, 46:12522-12529, 2007.
- Luk, KC, Kehm, VM, Zhang, B, O’Brien, P, Trojanowski, JQ, Lee, VMY. α-Synuclein fibril propagation accelerates neurodegeneration in a transgenic mouse model of α-synucleinopathies. J Exper Med, In press, 2012.
- Luk, CK, Mills, IP, Trojanwowski, JQ, Lee, VMY. Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibits fibril assembly. Biochem, 47:12614-12625, 2008. PMC2648307
- Luk, KC, Song, C, O’Brien, P, Stieber, A, Branch, J, Brunden, KR, Trojanowski, JQ, Lee, VMY. Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proc.Nat.Acad Sci, 106:20051-20056, 2009. PMC2785290
- Mastroberardino, PG, Hoffman, EK, Horowitz, MP, Betarbet, R, Taylor, G, Cheng, D, Na, HM, Gutekunst, C, Gearing, M, Trojanowski, JQ Anderson, M, Chu, CT, Peng, J, Greenamyre,JT.A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson’s disease. Neurobiol Dis, 34:417-431, 2009. PMC2784936
- McCluskey, LF, Elman, LB, Martinez-Lage, M, Siderowf, A, Trojanowski, JQ ALS-Plus syndrome with TAR DNA-binding protein-43 pathology. Arch Neurol, 66:121-124, 2009.
- Mendez, I, Vinuela, A, Astradsson, A, Mukhida, K, Hallett, P, Robertson, H, Tierney, T, Holness, R, Dagher, A, Trojanowski, JQ, Isacson, O Dopamine and serotonin neurons implanted into Parkinson’s diseae patients survive for 14 years: Implications for etiopathogensis. Nat.Med, 14:507-509, 2008. PMC2656682
- Montine, T., Phelps, C., Beach, T., Bigio, E., Cairns, N., Dickson, D.W., Duyckaerts, C., Frosch, M., Masliah, E., Mirra, S., Nelson, P., Schneider, J., Thal, D.R., Trojanowski, J.Q., Vinters, H., Hyman, B., National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: A practical approach. Acta Neuropathol., 123:1-11, 2012. PMC3266529
- Murray, R, Neumann, M, Forman, MS, Farmer, J, Massimo, L, Rice, A, Miller, BL, Johnson, JK, Clark, CM, Hurtig, HI, Gorno-Tempini ML, Lee, VMY., Trojanowski, JQ, Grossman, M Cognitive and motor assessment in autopsy-proven corticobasal degeneration. Neurology, 68:1274-1283, 2007.
- Nakashima-Yasuda, H, Uryu, K, Robinson, J, Xie, SX, Hurtig, H, Duda, J, Arnold, SE, Siderowf, A, Grossman, M, Leverenz, JB, Lopez, O, Hamilton, R, Tsuang, DW, Galasko, D, Masliah, E, Kaye, J, Woltjer, R., Clark, CM, Montine, TJ, Lee, VM.Y., Trojanowski, JQ Co-morbidity of TDP-43 proteinopathy in Lewy body diseases. Acta Neuropathol, 114:221-229, 2007.
- Pantelyat, A, Dreyfuss, M, Moore, P, Gross, R, Schuck, T, Irwin, D, Trojanowski, JQGrossman, M Acalculia in autopsy proven-corticobasal degeneration. Neurol, 76:S61-S63, 2011.
- Rankin, KP, Mayo, MC, Seeley, WW, Lee, S, Rabinovici, G, Gorno-Tempini, ML, Boxer, AL, Weiner, MW, Trojanowski, JQ, DeArmond, SJ, and Miller, BL Behavioral-variant frontotemporal dementia with corticobasal degeneration pathology: Phenotypic comparison to bvFTD with Pick’s disease. J. Mol Neurosci, 45:594-608, 2011. PMC3208125
- Roy, S, Lee, VMY., Trojanowski, JQ.Axonal transport and neurodegenerative diseases. In: Encyclopedia Of Neuroscience, LR.Squire (Ed.), Vol 1, Oxford Academic Press, pp. 1199-1203, 2009.
- Roy, S, Lee, VMY., Trojanowski, JQ Axonal transport and neurodegenerative diseases. In: Handbook Of The Neuroscience Of Aging, PR Hof, and CV Mobbs (Eds), Elsevier Academic Press, pp. 107-112, 2009.
- Roy, S, Winton, MJ, Black, MM, Trojanowski, JQ, Lee, VMY. Rapid and intermittent co-transport of slow component-b proteins. J Neurosci, 27:3131-3138, 2007.
- Roy, S, Winton, MJ, Black, MM, Trojanowski, JQ, Lee, VMY Lee.Cytoskeletal requirements in axonal transport of slow component-b. J Neurosci, 28:5248-5256, 2008. PMC2648304
- Shaw, LM, Korecka, M, Clark, CM, Lee, VMY., Trojanowski, JQ Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics. Nat Rev Drug Discovery, 6:295-303, 2007.
- Siderowf, A, Xie, SX, Hurtig, H, Weintraub, D, Duda, J, Chen-Plotkin, A, Shaw, LM, Van Deerlin, V, Trojanowski, JQ, Clark, CM CSF Aβ1-42 predicts cognitive decline in Parkinson’s disease. Neurol, 75:1055-1061, 2010. PMC3032425
- Skovronsky, D, Lee, VMY., Trojanowski, JQ Tau in parkinsonian diseases. In: Parkinson’s Disease: Genetics And Pathogenesis, T Dawson (Ed.), Marcel Dekker, New York, NY, pp: 187-198, 2007.
- Soper, JH, Roy, S, Stieber, A, Lee, E, Wilson, RB, Trojanowski, JQ, Burd, CG, Lee, VM.Y. Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. Mol Biol Cell, 19:1093-1103, 2008. PMC2262993
- Soper, J, Trojanowski, JQ, Lee, VMY. Alpha-synuclein in Parkinson’s disease. In: Parkinson’s Disease: Genetics And Pathogenesis, T Dawson (Ed.), Marcel Dekker, New York, NY, pp:167-186, 2007. PMC2262993
- The Parkinson Progression Marker Initiative (PPMI). The Parkinson Progression Marker Initiative. Prog Neurobiol, 95:629-635, 2011.
- Trojanowski, JQ, Arnold, SE, Karlawish, JH, Brunden, K, Cary, M, Davatzikos, C, Detre, J, Gaulton, G, Grossman, M, Hurtig, H, Jedrziewski, K, McCluskey, L, Naylor, M, Polsky, D, Schellenberg, GD, Siderowf, A, Shaw, LM, Van Deerlin, V, Wang, LS., Werner, R, Xie, SX, Lee, VMY. Lee. Design of comprehensive Alzheimer’s disease centers to address unmet national needs. Alzheimer’s & Dementia, 6:1150-155, 2010. PMC2842603
- Trojanowski, JQ (Editor, NeuroSignals Special Issue) Penn Neurodegenerative Disease Research – In The Spirit Of Ben Franklin. NeuroSignals, Volume 16, 2008.
- Trojanowski, JQ PENN neurodegenerative disease research – In the spirit of Benjamin Franklin. NeuroSignals, 16:5-10, 2008.
- Trojanowski, JQ, Forman, MS, Lee, VMY. Alzheimer’s disease, Parkinson’s disease and frontotemporal dementias: Different manifestations of protein misfolding. In: Advances In Alzheimer’s And Parkinson’s Disease. A Fisher, M Memo, F Stocchi, I Hanin, (Eds.), Springer Science, New York, NY, Vol. 37, pp. 123-133, 2008.
- Trojanowski, JQ, Hampel, H Neurodegenertative disease biomarkers: Guideposts for disease prevention through early diagnosis and intervention. Prog Neurobiol, 95:491-495, 2011.
- Trojanowski, JQ, Revesz, T Proposed neuropathological criteria for the postmortem diagnosis of multiple system atrophy. Neuropathol. Appl Neurobiol, 33:615-620, 2007.
- Uryu, K, Haddix, T, Robinson, J, Nakashima-Yasuda, H, Lee, VMY., Trojanowski, JQ Burden of neurodegenerative diseases in a cohort of medical examiner subjects. J Forensic Sci, 55:642-645, 2010. PMC2951130
- Uryu, K, Nakashima-Yasuda, H, Forman, M, Kwong, LK, Clark, CM, Grossman, M, Miller, BL, Kretzschmar, HA, Lee, VMY., Trojanowski, JQ, Neumann, M Concomitant TDP-43 pathology is present in Alzheimer’s disease and corticobasal degeneration. J Neuropath Exper. Neurol., 67:555-564, 2008.
- Volpicelli-Daley, LA. Luk, KC, Patel, TP, Tanik, SA, Riddle, DM, Stieber, A, Meany, DF, Trojanowski, JQ, and Lee, VMY. Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron, 72:57-71, 2011. PMC3204802
- Wang, Y, Shi, M, Chung, KA, Zabetian, CP, Leverenz, JB, Berg, D, Srulijes, K, Trojanowski, JQ, Lee, VMY., Siderowf, AD, Hurtig, H, Litvan, I, Schiess, MC, Peskind, ER, Masuda, M, Hasegawa, M, Lin, X. Pan, C, Galasko, D, Goldstein, DS, Jensen, PH, Yang, H, Cain, KC, and Zhang, J.Phosphorylated α-synuclein in Parkinson disease and related parkinsonism. Sci Transl.Med, In press, 2012.
- Wider, C, Dachsel, JC, Soto, AI, Heckman, MG, Diehl, NN, Yue, M, Lincoln, S, Aasly, JO, Haugarvoll, K, Trojanowski, JQ, Papapetropoulos, S, Mash, D, Rajput, A, Rajput, AH, Gibson, JM, Lynch, T, Dickson, DW, Uitti, RJ, Wszolek, ZK, Farrer, MJ, Ross, OA FGF20 and Parkinson's disease: No evidence of association or pathogenicity via alpha-synuclein expression. Mov Disord, 24:455-459, 2009. PMC2875476
- Xie, SX, Baek, Y, Grossman, M, Arnold, S, Karlawish, J, Siderowf, A, Hurtig, H, Elman, L, McCluskey, L, Van Deerlin, V, Lee, VMY., Trojanowski, J. Building an integrated neurodegenerative disease database at an academic health center. Alzheimer & Dementia, 7:e84-e93, 2011. PMC3145967
- Yu, C-E, Bird, TD, Bekris, L.M., Leverenz, JB, Steinbart, E, Galloway, NM, Feldman, H, Woltjer, R, Miller, CA, Wood, EM, Grossman, M, McCluskey L, Clark CM, Neumann, M, Danek, A, Galasko, DR, Arnold, SE, Chen-Plotkin, A, Karydas, A, Miller, BL, Trojanowski, JQ, Lee, VMY., Schellenberg, GD, Van Deerlin, VM The spectrum of mutations in progranulin: A collaborative study screening 545 cases of neurodegeneration. Arch Neurol, 67:161-170, 2010. PMC2901991
Data Management and Biostatistics Core
This Core will continue to develop and maintain a relational database of demographic, clinical, genetic, biomarker, imaging and neuropathological data gathered and used by Clinical Core (Core B), Neuropathology, Biomarker and Genetics Core (Core C), and Projects I-IV and to support the network and associated computing facilities for the database and data analysis operations of the Udall Center.
The Core will also advise investigators on study design for all Projects and Cores; to assist investigators in the analysis of their data using rigorous statistical methods; to assist in the preparation of reports, abstracts, and manuscripts; to assist investigators in conducting exploratory analyses that may lead to the generation of new hypotheses for future research; to develop new statistical methodologies and extend existing methodologies where needed for analysis of Udall Center data, and to provide bioinformatics support for analysis of large complex data sets such as those that will come from ongoing GWAS and epigenetic studies described in Core C as well as to correlate deep phenotyping data on Udall subjects with alpha-synuclein (a-syn) strain data to link the characteristics of these strains to distinct clinical-pathologically defined phenotypes of PD without and with dementia (PDD) and dementia with Lewy bodies (DLB).
| Sharon Xie, PhD | Core Leader |
Click for Complete Recent Publications
Core Publications
- Nakashima-Yasuda, H, Uryu, K, Robinson, J, Xie, SX, Hurtig, H, Duda, JE, Arnold, SE, Siderowf, A, Grossman, M, Leverenz, JB, Woltjer, R, Lopez, OL, Hamilton, R, Tsuang, DW, Galasko, D, Masliah, E, Kaye, J, Clark, CM, Montine, TJ, Lee, VMY., Trojanowski, JQ: Co-Morbidity of TDP-43 proteinopathy in lewy body related diseases. Acta Neuropath, 114:221-229, 2007
- Weintraub, D, Xie, S, Karlawish, J, Siderowf, A: Differences in depression symptoms in patients with Alzheimer's and Parkinson's diseases: evidence from the 15-item geriatric depression scale (GDS-15). Internat J Geriat Psych, 22:1025-1030, 2007.
- Geser, F, Winton, MJ, Kwong, LK, Xu, Y, Xie, SX, Igaz LM, Garruto, RM, Perl, DP, Galasko, D, Lee, VM-Y, Trojanowski, JQ: Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. Acta Neuropathologica, 115:133-145, 2008.
- Hoops, S, Nazem, S, Siderowf, AD, Duda, JE, Xie, SX, Stern, MB, Weintraub, D: Validity of the MoCA and MMSE in the detection of MCI and dementia in Parkinson disease. Neurol, 73:1738-1745, 2009. PMC2788810
- Rosenthal, E, Brennan, L, Xie, S, Hurtig, H, Milber, J, Weintraub, D, Karlawish, J, Siderowf, A: Association between cognition and function in Parkinson disease patients with and without dementia. Movement Disorders 25:1170-1176, 2010. PMC2963089
- Siderowf, A, Xie, SX, Hurtig, H, Weintraub, D, Duda, J, Chen-Plotkin, A, Shaw, LM, Van Deerlin, V, Trojanowski, JQ, Clark, C: CSF Amyloid Beta 1-42 predicts cognitive decline in Parkinson's disease. Neurol, 75:1055-1061, 2010. PMC2942062
- Stephenson, R, Houghton, D, Sundarararjan, S, Doty, RL, Stern, M, Xie, S, Siderowf, A: Odor identification deficits are associated with increased risk of neuro-psychiatric complications in patients with Parkinson's disease. Mov Disord, 25:2099-2104, 2010. PMC2963102
- Trojanowski, JQ, Arnold, S, Karlawish, J, Brunden, K, Cary, M, Davatzikos, C, Detre, J, Gaulton, G, Grossman, M, Hurtig, H, Jedrziewski, K, McCluskey, L, Naylor, M, Polsky, D, Schellenberg, GD, Siderowf, A, Shaw, LM, Van Deerlin, V, Wang, L-S, Werner, R, Xie, SX, Lee, VM-Y: Design of comprehensive Alzheimer's Disease Centers to address unmet national needs. Alzheimer's & Dementia, 6:150-155, 2010. PMC2842603
- Chen-Plotkin, A, Hu, WT, Siderowf, A, Weintraub, D, Goldmann Gross, R, Hurtig, HI, Xie, SX, Arnold, SE, Grossman, M, Clark, CM, Shaw, LM, McCluskey, L, Elman, L, Karlawish, J, Van Deerlin, VM, Lee, VMY., Soares, H, Trojanowski, JQ: Plasma EGF levels correlate with cognitive performance and predict cognitive impairment in Parkinson's disease. Ann Neurol, 69:655-663, 2011. PMC3155276
- Xie, SX, Baek, Y, Grossman, M, Arnold, SE, Karlawish, J, Siderowf, A, Hurtig, H, Elman, L, McCluskey, L, Van Deerlin, V, Lee, VMY., Trojanowski, JQ: Building an integrated neurodegenerative disease database at an academic health center. Alz & Dem, 7:e84-e93, 2011 PMC3145967
- Falcone, DC, Wood, EM, Xie, SX, Siderowf, A, Van Deerlin, VM: Genetic testing and Parkinson disease: assessment of patient knowledge, attitudes, and interest. J Genet Couns, In press, 2011.
- Libon, DJ, Rascovsky, K, Gross, RG, White, MT, Xie, SX, Dreyfuss, BA, Boller, A, Massimo, L, Moore, P, Kitain, J, Coslett, HB, Chatterjee, A, Grossman, M.: The Philadelphia Brief Assessment of Cognition (PBAC): A Validated Screening Measure for Dementia. Clin Neuropsychol, In press, 2011.
- Weintraub, D, Mamikonyan, E, Papay, K, Shea, JA, Xie, SX, Siderowf, A: Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale. Mov Disord, In press, 2011.
- Weintraub, D, Dietz, N, Duda, JE, Wolk, D, Doshi, J, Xie, SX, Davatzikos, C, Clark, C, Siderowf, A: Alzheimer's disease pattern of brain atrophy predicts cognitive decline in Parkinson's disease. Brain, In press, 2011.
- Weintraub, D, Doshi, J, Koka, D, Davatzikos, D, Siderowf, AD, Duda, JE, Wolk, DA, Moberg, PJ, Xie, SX, Clark, CM: Neurodegeneration across stages of cognitive decline in Parkinson’s disease. Arch Neurol, In press, 2011.
- Ash, S, Xie, S, Gross, RG, Dreyfuss, M, Boller, A, Camp, E, Morgan, B, O-Shea, J, Grossman, M: The organization and anatomy of narrative comprehension and expression in Lewy body spectrum disorders. Neuropsychology, in press, 2011.