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What does that mean?

Research dictionaryThe terminology used in research and clinical trials can be unusual. Check back frequently as we add to this helpful guide of key words and terms used in research.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

 

cerebrospinal fluid sampling (CSF)

 

  see also lumbar puncture
clinical trial (1)  

Scientific tests of the effectiveness and safety of a therapeutic agent, as a drug or vaccine; clinical trials are conducted under FDA approval and strict protocols. Clinical trials are necessary before a drug or a treatment can be approved and available for general use.

 

cohort (1)  

A defined population in an epidemiological study; a group of individuals having a statistical factor in common. For example, the longitudinal study followed two cohorts for five years - one with memory loss and one without.

 

diagnostic study  

A study that uses technologies, such as magnetic resonance imaging (MRI) or PET scanning, and examines samples of blood and cerebrospinal fluid to obtain comprehensive inital data and to better understand the physiological changes that occur over time in the body as a disease progresses.

 

double-blind, placebo-controlled  

Study or trial in which neither the participants nor the clinicians involved know if a participant is receiving the active medication being studied or an inert substance known as a placebo.

 

EEG (1)  

an abbreviation of electroencephalogram; a graphic record, often on paper somewhat like an EKG strip, of the electrical activity of the brain as recorded by an electroencephalograph. Also called an encephalogram.

 

longitudinal (1)  

Involving the repeated observation or examination of a set of subjects over time, with respect to one or more study variables.

 

lumbar puncture  

Also known as a spinal tap, the procedure to remove cerebrospinal fluid, so called because the area of the spinal column used to obtain the sample is in the lumbar spine, or lower section of the back. For more explanation, click here.

 

MCI  

Mild cognitive impairment (MCI) describes a subtle but measurable memory problem beyond that expected in normal aging. Individuals with MCI do not have symptoms of dementia and are able to perform their full range of normal daily activities.

 

psychometric (1)  

Quantitative tests for the measurement of cognitive and personality variables.

 

randomized trial or study  

Trial or study where participants are assigned at random to separate groups thereby allowing the objective comparison of different treatments.

 

subclinical  

Not manifesting, or showing, characteristic clinical symptoms.

 

 

1. Merriam-Webster's Medical Dictionary, © 2002